ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(26), С. 33169 - 33181
Опубликована: Июнь 25, 2024
Inducing
immunogenic
cell
death
(ICD)
is
a
promising
strategy
for
cancer
immunotherapy.
Shikonin
(SHK),
naphthoquinone
compound
from
Lithospermum
erythrorhizon,
can
stimulate
antitumor
immunity
by
inducing
ICD.
Nevertheless,
the
immunogenicity
of
tumor
cells
killed
SHK
weak.
Endoplasmic
reticulum
(ER)
stress
an
important
intracellular
pathway
ICD
effect.
Curcumin
(CUR)
directly
induce
ER
disrupting
Ca2+
homeostasis,
which
might
enhance
SHK-induced
A
self-delivery
effect
nanobooster
(CS-PEG
NPs)
was
developed
self-assembly
(ICD
inducer)
and
CUR
enhancer)
with
assistance
DSPE-PEG2K
chemoimmunotherapy.
CS-PEG
NPs
possessed
effective
CT26
cellular
uptake
accumulation
ability.
Moreover,
enhanced
cytotoxicity
against
apoptosis
promotion
were
achieved
due
to
synergistic
SHK.
Notably,
induced
obvious
homeostasis
disruption,
stress,
Subsequently,
neoantigens
produced
robust
in
vivo
promoted
dendritic
maturation,
further
recruited
activated
cytotoxic
T
lymphocytes.
Superior
efficacy
systemic
observed
CT26-bearing
BALB/c
mouse
model
without
side
effects
major
organs.
This
study
offers
strong
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(3), С. 1302 - 1322
Опубликована: Фев. 12, 2024
The
treatment
of
bone
defects
has
been
a
long-standing
challenge
in
clinical
practice.
Among
the
various
tissue
engineering
approaches,
there
substantial
progress
development
drug
delivery
systems
based
on
functional
drugs
and
appropriate
carrier
materials
owing
to
technological
advances
recent
years.
A
large
number
nanocarriers
have
developed
applied
improve
complex
osteogenic
microenvironment,
including
for
promoting
activity,
inhibiting
osteoclast
exerting
certain
antibacterial
effects.
This
Review
discusses
physicochemical
properties,
loading
mechanisms,
advantages
disadvantages
nanoparticles
(NPs)
used
constructing
systems.
In
addition,
we
provide
an
overview
microenvironment
regulation
mechanism
nanoparticle
(NP)
carriers
construction
strategies
Finally,
NP
are
summarized
along
with
their
prospects
future
research
trends
engineering.
thus
provides
advanced
design
application
NPs
defects.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(5), С. 100953 - 100953
Опубликована: Авг. 23, 2024
While
spray-drying
has
been
widely
utilized
to
improve
the
bioavailability
of
poorly
water-soluble
drugs,
outcomes
often
exhibit
suboptimal
particle
size
distribution
and
large
sizes,
limiting
their
effectiveness.
In
this
study,
we
introduce
electrostatic
spraying
as
an
advanced
technology
tailored
for
enabling
fabrication
nanoparticles
with
fine
uniform
distribution.
Regorafenib
(1
g),
a
model
drug,
copovidone
(5
sodium
dodecyl
sulfate
(0.1
g)
were
dissolved
in
200
ml
ethanol
subjected
conventional-spray-dryer
spray
dryer.
The
spray-dried
(ESDN)
showed
smaller
sizes
better
uniformity
compared
conventional
(CSDN).
ESDN
demonstrated
significantly
enhanced
solubility
rapid
release
water.
Abstract
Multi‐drug
resistance
(MDR)
is
a
major
cause
of
cancer
therapy
failure.
Photodynamic
(PDT)
promising
modality
that
can
circumvent
MDR
and
synergize
with
chemotherapies,
based
on
the
generation
reactive
oxygen
species
(ROS)
by
photosensitizers.
However,
overproduction
glutathione
(GSH)
cells
scavenges
ROS
restricts
efficacy
PDT.
Additionally,
side
effects
normal
tissues
are
unavoidable
after
PDT
treatment.
Here,
to
develop
organic
systems
deliver
effective
anticancer
chemotherapy
simultaneously
very
little
effects,
three
GSH‐sensitive
photosensitizer‐drug
conjugates
(CyR‐SS‐L)
designed
synthesized.
CyR‐SS‐L
localized
in
mitochondria
then
cleaved
into
CyR‐SG
SG‐L
parts
reacting
consuming
high
levels
intracellular
GSH.
Notably,
generates
tumor
instead
be
exploited
for
part
used
chemotherapy.
inhibits
better
inhibitory
activity
than
indocyanine
green,
photosensitizer
(PS)
clinical
applications.
The
results
appear
first
show
may
as
an
alternative
agent
more
against
cancers
without
obvious
damaging
combination
PDT,
GSH
depletion,
Oxidation
modulators
regarding
antioxidants
and
reactive
oxygen
species
(ROS)
inducers
have
been
used
for
the
treatment
of
many
diseases.
However,
a
systematic
review
that
refers
to
delivery
system
divergent
modulation
oxidative
level
within
biomedical
scope
is
lacking.
To
provide
comprehensive
summarization
analysis,
we
pilot
designs
delivering
main
applications
inflammatory
tumor
therapy.
On
one
hand,
based
can
be
employed
downregulate
ROS
levels
at
sites
treat
diseases
(e.g.,
skin
repair,
bone-related
diseases,
organ
dysfunction,
neurodegenerative
diseases).
other
upregulate
site
kill
cells
disrupt
endogenous
balance
induce
lethal
ROS).
Besides
current
systems
application
cases,
prospects
future
research
are
also
provided
identify
intelligent
strategies
inspire
new
concepts
modulators.
Molecular Pharmaceutics,
Год журнала:
2023,
Номер
20(9), С. 4387 - 4403
Опубликована: Авг. 10, 2023
Messenger
RNA
(mRNA)-based
therapies
have
gained
significant
attention,
following
the
successful
deployment
of
mRNA-based
COVID-19
vaccines.
Compared
with
traditional
methods
genetic
modification,
offer
several
advantages,
including
a
lower
risk
mutations,
temporary
and
controlled
therapeutic
gene
expression,
shorter
production
time,
which
facilitates
rapid
responses
to
emerging
health
challenges.
Moreover,
shown
immense
potential
in
treating
wide
range
diseases
cancers,
immune
diseases,
neurological
disorders.
However,
current
limitations
non-viral
vectors
for
efficient
safe
delivery
mRNA
therapies,
such
as
low
encapsulation
efficiency,
toxicity,
limited
stability,
necessitate
exploration
novel
strategies
overcome
these
challenges
fully
realize
therapeutics.
Coacervate-based
systems
recently
emerged
promising
enhancing
delivery.
Coacervates,
are
formed
by
aggregation
two
or
more
macromolecules,
great
delivering
therapeutics
due
their
ability
form
separated
macromolecular-rich
fluid
phase
an
aqueous
environment.
This
separation
enables
entrapment
protection
agents
from
degradation
well
cellular
uptake
release.
Additionally,
natural
affinity
coacervates
molecules
presents
excellent
opportunity
targeted
cells
tissues,
making
coacervate-based
attractive
option
therapies.
review
highlights
advantages
enable
Coacervates
protect
enzymatic
enhance
uptake,
leading
sustained
expression.
Despite
properties,
specific
use
vehicles
remains
underexplored.
aims
provide
comprehensive
overview
coacervate-mediated
mRNA,
exploring
properties
applications
different
coacervating
optimization
involved
encapsulation,
release,
translation
via
Through
analysis
recent
advancements
recommended
future
directions,
our
sheds
light
on
role
therapeutics,
highlighting
its
groundbreaking
drug
therapy.
Pharmaceutics,
Год журнала:
2023,
Номер
15(10), С. 2490 - 2490
Опубликована: Окт. 19, 2023
Bacteria
and
bacterial
components
possess
multifunctional
properties,
making
them
attractive
natural
bio-nanocarriers
for
cancer
diagnosis
targeted
treatment.
The
inherent
tropic
motile
nature
of
bacteria
allows
to
grow
colonize
in
hypoxic
tumor
microenvironments
more
readily
than
conventional
therapeutic
agents
other
nanomedicines.
However,
concerns
over
biosafety,
limited
antitumor
efficiency,
unclear
tumor-targeting
mechanisms
have
restricted
the
clinical
translation
application
based
on
components.
Fortunately,
therapies
combined
with
engineering
strategies
nanotechnology
may
be
able
reverse
a
number
challenges
bacterial/bacterial
component-based
biotherapies.
Meanwhile,
tend
enhance
versatility
bionanoplasmic
nanoplatforms
improve
biosafety
inhibit
tumorigenesis
metastasis.
This
review
summarizes
advantages
therapy,
outlines
combinatorial
nanocarriers
components,
discusses
their
applications.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 1, 2023
Cancer
presents
a
formidable
threat
to
human
health,
with
the
majority
of
cases
currently
lacking
complete
cure.
Frequently,
chemotherapy
drugs
are
required
impede
its
progression.
However,
these
frequently
suffer
from
drawbacks
such
as
poor
selectivity,
limited
water
solubility,
low
bioavailability,
and
propensity
for
causing
organ
toxicity.
Consequently,
concerted
effort
has
been
made
seek
improved
drug
delivery
systems.
Nano-drug
systems
based
on
biodegradable
polyesters
have
emerged
subject
widespread
interest
in
this
pursuit.
Extensive
research
demonstrated
their
potential
offering
high
effective
encapsulation,
controlled
release,
minimal
Notably,
poly
(ε-caprolactone)
(PCL),
(lactic-co-glycolic
acid)
(PLGA),
polylactic
acid
(PLA)
gained
prominence
most
widely
utilized
options
carriers
nano
system.
This
paper
comprehensively
reviews
recent
materials
nano-carriers
delivering
chemotherapeutic
drugs,
summarizing
latest
advancements,
acknowledging
limitations,
forecasting
future
directions.
