ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(26), С. 33169 - 33181
Опубликована: Июнь 25, 2024
Inducing
immunogenic
cell
death
(ICD)
is
a
promising
strategy
for
cancer
immunotherapy.
Shikonin
(SHK),
naphthoquinone
compound
from
Lithospermum
erythrorhizon,
can
stimulate
antitumor
immunity
by
inducing
ICD.
Nevertheless,
the
immunogenicity
of
tumor
cells
killed
SHK
weak.
Endoplasmic
reticulum
(ER)
stress
an
important
intracellular
pathway
ICD
effect.
Curcumin
(CUR)
directly
induce
ER
disrupting
Ca2+
homeostasis,
which
might
enhance
SHK-induced
A
self-delivery
effect
nanobooster
(CS-PEG
NPs)
was
developed
self-assembly
(ICD
inducer)
and
CUR
enhancer)
with
assistance
DSPE-PEG2K
chemoimmunotherapy.
CS-PEG
NPs
possessed
effective
CT26
cellular
uptake
accumulation
ability.
Moreover,
enhanced
cytotoxicity
against
apoptosis
promotion
were
achieved
due
to
synergistic
SHK.
Notably,
induced
obvious
homeostasis
disruption,
stress,
Subsequently,
neoantigens
produced
robust
in
vivo
promoted
dendritic
maturation,
further
recruited
activated
cytotoxic
T
lymphocytes.
Superior
efficacy
systemic
observed
CT26-bearing
BALB/c
mouse
model
without
side
effects
major
organs.
This
study
offers
strong
RSC Advances,
Год журнала:
2022,
Номер
12(10), С. 6336 - 6346
Опубликована: Янв. 1, 2022
In
the
current
study,
drug
carrier
efficiency
of
graphyne
(GRP)
for
transfer
hesperetin
(HPT)
is
evaluated
first
time.
The
GRP
efficacy
as
a
investigated
using
density
functional
theory
(DFT)
technique
to
calculate
various
physiochemical
characteristics
such
dipole
moment,
bandgap,
and
chemical
reactivity-descriptors
HPT,
HPT@GRP
complex.
non-covalent-interaction
(NCI)
plot
indicated
that
HPT
have
weak
interaction
force,
which
fundamental
drug's
noticeable
offloading
from
at
its
target
location.
According
frontier
molecular
orbital
analysis,
highest
occupied
(HOMO)
distributes
charge
GRP,
lowest
unoccupied
(LUMO)
during
excitation.
Charge
further
supported
by
charge-decomposition-analysis,
interprets
extensive
overlap
between
orbitals.
case
gas
phase,
ACS Nano,
Год журнала:
2023,
Номер
17(24), С. 24972 - 24987
Опубликована: Дек. 13, 2023
Tumor
metastasis
is
an
intricate
multistep
process
regulated
via
various
proteins
and
enzymes
modified
secreted
by
swollen
Golgi
apparatus
in
tumor
cells.
Thus,
complex
considered
as
important
target
for
the
remedy
of
metastasis.
Currently,
targeting
technologies
are
mostly
employed
Golgi-specific
fluorescent
probes
diagnosis,
but
their
applications
therapy
rarely
reported.
Herein,
we
proposed
a
prodrug
(INR)
that
can
destroy
apparatus,
which
consisted
indomethacin
(IMC)
moiety
retinoic
acid
(RA),
disrupting
agent.
The
linker
between
IMC
RA
was
designed
hypoxia-responsive
nitroaromatic
structure,
ensured
release
prototype
drugs
hypoxic
microenvironment.
Furthermore,
INR
could
be
assembled
with
pirarubicin
(THP),
anthracycline,
to
form
carrier-free
nanoparticle
(NP)
emulsion-solvent
evaporation
method.
A
small
amount
mPEG2000-DSPE
added
shield
positive
charges
improve
stability
obtain
PEG-modified
(PNP).
It
proved
released
cells
hypoxia
promoted
release.
destructive
effect
amplified
owing
ability
IMC,
also
inhibited
protumor
COX-2/PGE2
signaling.
Finally,
PNP
exhibited
excellent
curative
efficacy
on
4T1
primary
its
pulmonary
hepatic
molecular
therapeutic
adapted
multifarious
drug
delivery
systems
disease
models,
expanded
application
tactics
treatment.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 5197 - 5211
Опубликована: Сен. 1, 2023
Introduction:
Silybin
(SLB)
as
an
effective
hepatoprotective
phytomedicine
has
been
limited
by
its
hydrophobicity,
poor
bioavailability
and
accumulation
at
lesion
sites.
Additionally,
present
drug
loading
methods
are
impeded
their
low
capacity,
potential
hazard
of
materials
therapeutic
effects.
Consequently,
there
is
a
pressing
need
to
devise
innovative
approach
for
preparing
nanosuspensions
loaded
with
both
SLB
Meglumine
salt
(SLB-M),
well
investigate
the
effects
against
hepatic
fibrosis.
Methods:
The
nanosuspension
(NS-SLB)
was
prepared
further
modified
hyaluronic
acid–cholesterol
conjugate
(NS-SLB-HC)
improve
CD44
targeting
proficiency
NS-SLB.
To
validate
ensure
minimal
cytotoxicity,
cellular
uptake
cytotoxicity
assessments
were
carried
out
nanosuspensions.
Western
blotting
employed
evaluate
anti-hepatic
fibrosis
efficacy
in
LX-2
cells
inhibiting
secretion
collagen
I.
Hepatic
mouse
models
used
confirm
effectiveness
NS-SLB
NS-SLB-HC
vivo.
Results:
Uniform
through
self-assembly,
achieving
high
rates
89.44%
60.67%,
respectively.
Both
showed
environments
mitigated
vitro.
demonstrated
target
activated
stellate
receptor-ligand
interaction
between
HA
CD44.
They
can
reverse
vivo
downregulating
TGF-β
α-SMA
Conclusion:
Designed
medical
excipient
analogue,
SLB-M
aimed
establish
preparation
method,
characterized
capacity
notable
impact
Keywords:
nanosuspension,
cells,
phytomedicines,
surfactant,
delivery
system
Biomacromolecules,
Год журнала:
2024,
Номер
25(6), С. 3685 - 3702
Опубликована: Май 23, 2024
Combination
therapy
has
emerged
as
a
promising
approach
for
treating
tumors,
although
there
is
room
improvement.
This
study
introduced
novel
strategy
that
combined
the
enhancement
of
apoptosis,
ferroptosis,
and
DNA
damage
to
improve
therapeutic
outcomes
prostate
cancer.
Specifically,
we
have
developed
supramolecular
oxidative
stress
nanoamplifier,
which
was
comprised
β-cyclodextrin,
paclitaxel,
ferrocene-poly(ethylene
glycol).
Paclitaxel
within
system
disrupted
microtubule
dynamics,
inducing
G2/M
phase
arrest
apoptosis.
Concurrently,
ferrocene
utilized
hydrogen
peroxide
generate
toxic
hydroxyl
radicals
in
cells
through
Fenton
reaction,
triggering
cascade
reactive
oxygen
species
expansion,
reduction
glutathione
levels,
lipid
peroxidation,
ferroptosis.
The
increased
number
inhibitory
effect
THZ531
on
repair
mechanisms
exacerbated
tumor
cells.
As
expected,
nanoparticles
demonstrated
excellent
drug
delivery
ability
or
tissues,
exhibited
favorable
biological
safety
vivo,
enhanced
killing
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(26), С. 33169 - 33181
Опубликована: Июнь 25, 2024
Inducing
immunogenic
cell
death
(ICD)
is
a
promising
strategy
for
cancer
immunotherapy.
Shikonin
(SHK),
naphthoquinone
compound
from
Lithospermum
erythrorhizon,
can
stimulate
antitumor
immunity
by
inducing
ICD.
Nevertheless,
the
immunogenicity
of
tumor
cells
killed
SHK
weak.
Endoplasmic
reticulum
(ER)
stress
an
important
intracellular
pathway
ICD
effect.
Curcumin
(CUR)
directly
induce
ER
disrupting
Ca2+
homeostasis,
which
might
enhance
SHK-induced
A
self-delivery
effect
nanobooster
(CS-PEG
NPs)
was
developed
self-assembly
(ICD
inducer)
and
CUR
enhancer)
with
assistance
DSPE-PEG2K
chemoimmunotherapy.
CS-PEG
NPs
possessed
effective
CT26
cellular
uptake
accumulation
ability.
Moreover,
enhanced
cytotoxicity
against
apoptosis
promotion
were
achieved
due
to
synergistic
SHK.
Notably,
induced
obvious
homeostasis
disruption,
stress,
Subsequently,
neoantigens
produced
robust
in
vivo
promoted
dendritic
maturation,
further
recruited
activated
cytotoxic
T
lymphocytes.
Superior
efficacy
systemic
observed
CT26-bearing
BALB/c
mouse
model
without
side
effects
major
organs.
This
study
offers
strong
