Journal of the Optical Society of America A,
Год журнала:
2023,
Номер
40(5), С. 955 - 955
Опубликована: Март 29, 2023
In
various
biomedical
optics
therapies,
knowledge
of
how
light
is
absorbed
or
scattered
by
tissues
crucial.
Currently,
it
suspected
that
a
low
compression
applied
to
the
skin
surface
may
improve
delivery
into
tissue.
However,
minimum
pressure
needed
be
significantly
increase
penetration
has
not
been
determined.
this
study,
we
used
optical
coherence
tomography
(OCT)
measure
attenuation
coefficient
human
forearm
dermis
in
regime
(<8kPa).
Our
results
show
pressures
such
as
4
kPa
8
are
sufficient
decreasing
at
least
1.0mm-1.
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
Abstract
Photothermal
disinfection
is
an
emerging
and
efficient
therapeutic
method
for
treating
various
infections.
However,
the
efficacy
hindered
by
poor
tissue
penetration
of
light.
While
optical
clearance
technology
can
enhance
light
transmission,
stratum
corneum
impedes
delivery
clearing
agents
to
deeper
tissues.
Herein,
dissolving
microneedle
(DMN)
patches
incorporating
photothermal
are
developed
improved
disinfection.
Such
DMN
obtained
using
sucrose
as
agent
polydopamine
(PDA)
nanoparticles
in
poly(vinyl
alcohol)
(PVA)
matrix.
After
treatment
with
composite
DMN,
transmittance
pigskin
increased
4.75
times.
The
DMNs
deliver
PDAs
subsurface
skin
while
improving
effect,
raising
temperature
45
°C
under
near‐infrared
(NIR)
irradiation
a
wavelength
808
nm.
In
deep
infection
model
(pigskin
coverage)
established
on
mouse
skin,
significantly
improve
wound
recovery
rate.
This
approach
expected
be
general
strategy
enhancing
anti‐infective
shows
great
potential
clinical
application
phototherapies.
Nanomaterials,
Год журнала:
2022,
Номер
12(13), С. 2173 - 2173
Опубликована: Июнь 24, 2022
As
a
non-invasive
and
non-specific
therapeutic
approach,
photodynamic
therapy
(PDT)
has
been
used
to
treat
antibiotic-resistant
bacteria
with
encouraging
efficacy.
Inspired
by
light,
the
photosensitizers
can
produce
excessive
reactive
oxygen
species
(ROS)
and,
thus,
effectively
destroy
or
kill
bacteria.
Cyanine
(Cy),
traditional
photosensitizer
for
PDT,
advantages
of
low
cytotoxicity
high
ROS
yield.
Yet,
water
solubility
photostability
Cy
are
poor,
which
substantially
limit
its
antibacterial
efficiency
clinical
translation.
Herein,
we
combined
carbomer
gel
(CBMG)
form
Cy-CBMG
hydrogel.
In
this
system,
was
evenly
dispersed
in
CBMG,
CBMG
significantly
improved
via
electrostatic
interactions.
The
developed
had
less
photodegradation
under
laser
irradiation
thus
elevate
accumulation
compound
presented
remarkable
ROS-induced
killing
efficacy
against
methicillin-resistant
Staphylococcus
aureus
(93.0%)
extended-spectrum
β-lactamase-producing
Escherichia
coli
(88.7%)
vitro.
Moreover,
as
potential
wound
dressing
material,
hydrogel
exhibited
excellent
biocompatibility
effective
antimicrobial
ability
promote
healing
vivo.
Overall,
work
proposed
practical
strategy
synthesize
photosensitizer-excipient
enhance
photophysical
property
PDT.
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
212, С. 115420 - 115420
Опубликована: Авг. 3, 2024
The
evaluation
of
the
diffusion
properties
different
molecules
in
tissues
is
a
subject
great
interest
various
fields,
such
as
dermatology/cosmetology,
clinical
medicine,
implantology
and
food
preservation.
In
this
review,
discussion
recent
studies
that
used
kinetic
spectroscopy
measurements
to
evaluate
made.
By
immersing
ex
vivo
agents
or
by
topical
application
those
vivo,
their
can
be
evaluated
collimated
transmittance
diffuse
reflectance
spectroscopy.
Using
method,
were
able
discriminate
between
healthy
diseased
tissues,
especially
cases
cancer
diabetes
mellitus.
case
cancer,
it
was
also
possible
an
increase
5%
mobile
water
content
from
cancerous
colorectal
kidney
tissues.
Considering
some
living
organisms
products
protect
them
deterioration
during
low
temperature
preservation
(cryopreservation),
knowing
agent
inclusion
may
reversed,
these
fields
are
discussed.
broadband
optical
physiological
diagnostic
data
method
acquire,
further
concerning
optimization
fruit
sweetness
poison
antidote
for
treatment
purposes
indicated
future
perspectives.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(20), С. 4867 - 4881
Опубликована: Янв. 1, 2024
Inflammatory
dermatoses
represent
a
global
problem
with
increasing
prevalence
and
recurrence
among
the
world
population.
Topical
glucocorticoids
(GCs)
are
most
commonly
used
anti-inflammatory
drugs
in
dermatology
due
to
wide
range
of
their
therapeutic
actions,
which,
however,
have
numerous
local
systemic
side
effects.
Hence,
there
is
growing
need
create
new
delivery
systems
for
GCs,
ensuring
drug
localization
pathological
site,
thus
effectiveness
therapy
lowering
risk
Here,
we
propose
novel
topical
particulate
formulation
GC
clobetasol
propionate
(CP),
based
on
use
porous
calcium
carbonate
(CaCO3)
carriers
vaterite
crystalline
form.
The
designed
contain
substantially
higher
CP
amount
than
conventional
dosage
forms
clinics
(4.5%
w/w
vs.
0.05%
w/w)
displayed
good
biocompatibility
effective
cellular
uptake
when
studied
fibroblasts
vitro.
Hair
follicles
an
important
reservoir
accumulation
skin
house
targets
its
action.
In
this
study,
demonstrated
successful
CP-loaded
(CP-CaCO3)
into
hair
rats
vivo
using
optical
coherent
tomography
(OCT).
Importantly,
OCT
monitoring
revealed
gradual
intrafollicular
degradation
within
168
h
abundant
follicle
filling
occurring
first
48
h.
Biodegradability
makes
proposed
system
especially
promising
searching
formulations
improved
safety
release
profile.
Our
findings
evidenced
great
potential
CaCO3
improving
dermal
bioavailability
poorly
water-soluble
GC.
Pharmaceutics,
Год журнала:
2022,
Номер
14(2), С. 287 - 287
Опубликована: Янв. 26, 2022
The
effect
of
low-dose
photodynamic
therapy
on
in
vivo
wound
healing
with
topical
application
5-aminolevulinic
acid
and
methylene
blue
was
investigated
using
an
animal
model
for
two
laser
radiation
doses
(1
4
J/cm
