Abstract
Viral
infections
in
humans
are
responsible
for
fatalities
worldwide
and
contribute
to
the
incidence
of
various
human
ailments.
Controllable
targeted
medicine
delivery
against
many
illnesses,
including
viral
infection,
may
be
significantly
aided
by
using
bacteria
bacteria-derived
products.
They
accumulate
diseased
tissues
despite
physical
obstacles,
where
they
can
launch
antiviral
immunity.
The
ability
genetically
chemically
modify
them
means
that
vaccinations
manufactured
delivered
affected
more
safely
effectively.
objective
this
study
is
provide
an
overview
latest
advancements
field
utilizing
bacterial
derivatives
as
carriers
administering
medication
treat
diseases
such
SARS-CoV-2,
hepatitis
B
virus,
C
immunodeficiency
papillomavirus,
influenza,
Ebola
virus.
Graphical
Pharmaceutics,
Год журнала:
2023,
Номер
15(4), С. 1052 - 1052
Опубликована: Март 24, 2023
Bacterial
membrane
vesicles
(BMVs)
are
known
to
be
critical
communication
tools
in
several
pathophysiological
processes
between
bacteria
and
host
cells.
Given
this
situation,
BMVs
for
transporting
delivering
exogenous
therapeutic
cargoes
have
been
inspiring
as
promising
platforms
developing
smart
drug
delivery
systems
(SDDSs).
In
the
first
section
of
review
paper,
starting
with
an
introduction
pharmaceutical
technology
nanotechnology,
we
delve
into
design
classification
SDDSs.
We
discuss
characteristics
including
their
size,
shape,
charge,
effective
production
purification
techniques,
different
methods
used
cargo
loading
encapsulation.
also
shed
light
on
release
mechanism,
carriers,
recent
remarkable
findings
potential
anticancer
antimicrobial
therapy.
Furthermore,
covers
safety
challenges
that
need
overcome
clinical
use.
Finally,
advancements
prospects
SDDSs
highlight
revolutionizing
fields
nanomedicine
delivery.
conclusion,
paper
aims
provide
a
comprehensive
overview
state-of-the-art
field
SDDSs,
encompassing
design,
composition,
fabrication,
purification,
characterization,
well
various
strategies
targeted
Considering
information,
aim
is
researchers
understanding
current
state
enabling
them
identify
gaps
formulate
new
hypotheses
accelerate
progress
field.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Май 23, 2023
Abstract
Cancer
immunotherapy
is
revolutionizing
oncology.
The
marriage
of
nanotechnology
and
offers
a
great
opportunity
to
amplify
antitumor
immune
response
in
safe
effective
manner.
Here,
electrochemically
active
Shewanella
oneidensis
MR-1
can
be
applied
produce
FDA-approved
Prussian
blue
nanoparticles
on
large-scale.
We
present
mitochondria-targeting
nanoplatform,
MiBaMc,
which
consists
decorated
bacteria
membrane
fragments
having
further
modifications
with
chlorin
e6
triphenylphosphine.
find
that
MiBaMc
specifically
targets
mitochondria
induces
amplified
photo-damages
immunogenic
cell
death
tumor
cells
under
light
irradiation.
released
antigens
subsequently
promote
the
maturation
dendritic
tumor-draining
lymph
nodes,
eliciting
T
cell-mediated
response.
In
two
tumor-bearing
mouse
models
using
female
mice,
triggered
phototherapy
synergizes
anti-PDL1
blocking
antibody
for
enhanced
inhibition.
Collectively,
study
demonstrates
biological
precipitation
synthetic
strategy
targeted
holds
potential
preparation
microbial
membrane-based
nanoplatforms
boost
immunity.
Abstract
Viral
infections
in
humans
are
responsible
for
fatalities
worldwide
and
contribute
to
the
incidence
of
various
human
ailments.
Controllable
targeted
medicine
delivery
against
many
illnesses,
including
viral
infection,
may
be
significantly
aided
by
using
bacteria
bacteria-derived
products.
They
accumulate
diseased
tissues
despite
physical
obstacles,
where
they
can
launch
antiviral
immunity.
The
ability
genetically
chemically
modify
them
means
that
vaccinations
manufactured
delivered
affected
more
safely
effectively.
objective
this
study
is
provide
an
overview
latest
advancements
field
utilizing
bacterial
derivatives
as
carriers
administering
medication
treat
diseases
such
SARS-CoV-2,
hepatitis
B
virus,
C
immunodeficiency
papillomavirus,
influenza,
Ebola
virus.
Graphical
