Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

ACS Nano, Год журнала: 2023, Номер 17(21), С. 20825 - 20849

Опубликована: Ноя. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Язык: Английский

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Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Год журнала: 2023, Номер 123(18), С. 10920 - 10989

Опубликована: Сен. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Язык: Английский

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Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges

Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(10), С. 2845 - 2916

Опубликована: Июль 13, 2024

Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract

Язык: Английский

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Application of Nanoparticles in Cancer Treatment: A Concise Review

Nanomaterials, Год журнала: 2023, Номер 13(21), С. 2887 - 2887

Опубликована: Окт. 31, 2023

Timely diagnosis and appropriate antitumoral treatments remain of utmost importance, since cancer remains a leading cause death worldwide. Within this context, nanotechnology offers specific benefits in terms therapy by reducing its adverse effects guiding drugs to selectively target cells. In comprehensive review, we have summarized the most relevant novel outcomes range 2010-2023, covering design application nanosystems for therapy. We established general requirements nanoparticles be used drug delivery strategies their uptake tumor microenvironment vasculature, including reticuloendothelial system surface functionalization with protein corona. After brief review classes nanovectors, covered different therapies. First, advances encapsulation (such as paclitaxel fisetin) into nanoliposomes nanoemulsions are described, well relevance current clinical trials. Then, polymeric presented, namely ones comprising poly lactic-co-glycolic acid, polyethylene glycol (and PEG dilemma) dendrimers. The quantum dots bioimaging is also covered, systems zinc sulfide indium phosphide. Afterwards, reviewed gold (spheres anisotropic) plasmon-induced photothermal iron oxide nanoparticles, such magnetite maghemite, has been analyzed fields, magnetic resonance imaging, immunotherapy, hyperthermia, delivery. Lastly, recent using carbon nanomaterials, graphene oxide, nanotubes, fullerenes, dots. Finally, compared passive active targeting theranostics. This aims (nano)mark on ongoing journey towards realizing remarkable potential realm therapeutics.

Язык: Английский

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Human Solid Tumors and Clinical Relevance of The Enhanced Permeation and Retention Effect: A ‘Golden Gate’ for Nanomedicine in Preclinical Studies?

Nanomedicine, Год журнала: 2023, Номер 18(2), С. 169 - 190

Опубликована: Янв. 1, 2023

Nanocarriers passively accumulate in solid tumors through irregular wide fenestrations neovasculature and increased retention due to poor lymphatic drainage, a phenomenon termed the enhanced permeation (EPR) effect. Although several preclinical reports have described role of EPR nanomedicine, its human tumor is obscure. There are distinct factors for mice versus humans, including size, heterogeneity nanomedicine pharmacokinetics. This review focuses on clinical studies demonstrating effect passive targeting. The article illustrates gaps that limit effectiveness elaborates strategies boost efficiency, relaying future outcomes designing clinically applicable EPR-based nanomedicine.Unlike healthy organ vasculature organs, leaky with drainage. Nanoparticles <200 nm reported be selectively taken up this physiology, process referred as Despite lots evidence, there lack success observed tumors. responsible rendition delivery by We highlighted key differences between murine models well listed effective approaches nanomedicine. These will bridge translation lay groundwork design anticancer therapies.

Язык: Английский

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Aminopeptidase N‐Responsive Conjugates with Tunable Charge‐Reversal Properties for Highly Efficient Tumor Accumulation and Penetration

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(9)

Опубликована: Янв. 3, 2023

Abstract Tumor enzyme‐responsive charge‐reversal carriers can induce efficient transcytosis and lead to tumor infiltration potent anticancer efficacy. However, the correlations of molecular structure with property, penetration, drug delivery efficiency are unknown. Herein, aminopeptidase N (APN)‐responsive conjugates were synthesized investigate these correlations. We found that monomeric unit polymer chain determined enzymatic hydrolysis rates, accordingly, accumulation penetration APN‐responsive conjugates. The conjugate moderate APN responsiveness balanced in vitro vivo overall process achieved best efficiency, giving antitumor This work provides new insight into design nanomedicines for cancer delivery.

Язык: Английский

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Screening of Zwitterionic Liposomes with Red Blood Cell‐Hitchhiking and Tumor Cell‐Active Transporting Capability for Efficient Tumor Entrance

Advanced Functional Materials, Год журнала: 2023, Номер 33(16)

Опубликована: Янв. 29, 2023

Abstract The active transport of nanoparticles into the solid tumor through cell transcytosis has shown great promise in cancer nanomedicine, but it is challenging to develop efficient transporting nanomedicines with potential for clinical translation. Here, a type tertiary amine oxide (TAO)‐containing zwitterionic liposomal nanocarriers developed that can hitchhike red blood cells (RBCs) vessels and enter tumors transcytosis. To boost active‐transporting capability, library TAO liposomes (TAOLs) different chemical structures particle sizes constructed screened by their stability capability. Two types TAOLs are identified induce rapid macropinocytosis endoplasmic reticulum/Golgi‐involved exocytosis. It found these RBCs gain long circulation, get off at site, effectively transcytosis, infiltrate whole tumor. chemotherapeutic drug‐loaded stop progression mice bearing human hepatocellular carcinoma HepG2 cells, exhibiting superior antitumor activity compared traditional drug. This study demonstrates strategy construct effective entrance.

Язык: Английский

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More Than Pigments: The Potential of Astaxanthin and Bacterioruberin-Based Nanomedicines

Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1828 - 1828

Опубликована: Июнь 26, 2023

Carotenoids are natural products regulated by the food sector, currently used as feed dyes and antioxidants in dietary supplements composing functional foods for human consumption. Of nearly one thousand carotenoids described to date, only retinoids, derived from beta carotene, have status of a drug pharmaceutical sector. In this review, we address novel field: transformation xanthophylls, particularly highly marketed astaxanthin practically unknown bacterioruberin, therapeutic agents altering their pharmacokinetics, biodistribution, pharmacodynamics through formulation nanomedicines. The antioxidant activity xanthophylls is mediated routes different those classical oral anti-inflammatory drugs such corticosteroids non-steroidal (NSAIDs): remarkably, lack but also toxicity. Formulated nanomedicines, gain mechanisms other than increased bioavailability. Loaded into ad hoc tailored nanoparticles protect structure throughout storage during gastrointestinal transit or skin penetration, can be targeted delivered selected inflamed cell groups, achieving massive intracellular concentration after endocytosis small doses formulation. Most first reports showing activities topical xanthophyll-based nanomedicines against chronic diseases inflammatory bowel disease, psoriasis, atopic dermatitis, dry eye disease emerged between 2020 2023. Here discuss detail preclinical performance, mostly vesicular polymeric nanoparticles, on cellular models vivo. results, although preliminary, auspicious enough speculate upon potential use administration treatment diseases.

Язык: Английский

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Stimuli‐Responsive Nanocarriers for Transcytosis‐Based Cancer Drug Delivery

Advanced NanoBiomed Research, Год журнала: 2024, Номер 4(3)

Опубликована: Янв. 8, 2024

Significant challenges persist in enhancing the delivery efficiency of tumor nanomedicines, predominantly due to difficulty successfully surpassing pathophysiological barriers. Enhancing penetration nanomedicines such conditions represents a pivotal goal advancing anticancer nanotherapeutics. Transcytosis emerges as promising solution this context, addressing limitations passive drug delivery. By harnessing diverse stimuli induce transcytosis, nanocarriers can achieve precise and deep penetration, resulting high therapeutic efficacy reduced systemic exposure compound. This review briefly examines various stimuli‐responsive nanosystems offers an overview outlook on development for transcytosis‐based cancer delivery, aiming provide informative insights design capable tissue enhanced efficacy.

Язык: Английский

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