Appropriate introduction of nitrile groups to balance NIR-II fluorescence imaging with photothermal therapy/photoacoustic imaging

Polymer Chemistry, Год журнала: 2023, Номер 14(25), С. 3008 - 3017

Опубликована: Янв. 1, 2023

Schematic illustration of nitrile-induced molecules enabling balance between NIR-II FLI and PTT/PAI.

Язык: Английский

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Bifunctional Tumor-Targeted Bioprobe for Phothotheranosis

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Background: Near-infrared (NIR) phototheranostics provide promising noninvasive imaging and treatment for head neck squamous cell carcinoma (HNSCC), capitalizing on its adjacency to skin or mucosal surfaces. Activated by laser irradiation, targeted NIR fluorophores can selectively eradicate cancer cells, harnessing the power of synergistic photodynamic therapy photothermal therapy. However, there is a paucity bioprobes showing tumor-specific targeting effective phototheranosis without hurting surrounding healthy tissues. Methods: We engineered bifunctional bioprobe designed precisely target HNSCC induce using bioconjugation cyclic arginine-glycine-aspartic acid (cRGD) motif zwitterionic polymethine fluorophore. The cytotoxic effects cRGD-ZW800-PEG were measured assessing heat reactive oxygen species (ROS) generation upon an 808-nm irradiation. then determined in vivo efficacy FaDu xenograft mouse model HNSCC, as well biodistribution clearance, customized portable system. Results: Real-time revealed that intravenously administered tumors rapidly within 4 h postintravenous injection tumor-bearing mice. Upon produced ROS simultaneously exhibited tumoral tissue affecting neighboring Importantly, all unbound cleared through renal excretion. Conclusions: By combination with tailored tumor selectivity, our ushers paradigm treatment. It promises safer more efficacious therapeutic avenues against cancer, marking substantial advancement field.

Язык: Английский

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Organic nanoparticles based on aza-boron dipyrromethene derivatives for combined photothermal and photodynamic cancer therapy

Materials Today Chemistry, Год журнала: 2024, Номер 37, С. 102018 - 102018

Опубликована: Март 23, 2024

Язык: Английский

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Photothermal lanthanide nanomaterials: From fundamentals to theranostic applications

BMEMat, Год журнала: 2024, Номер unknown

Опубликована: Май 17, 2024

Abstract Photothermal lanthanide nanomaterials with unique photophysical properties have been innovatively explored for diagnostics and non‐invasive therapies, hold great promise precision theranostics. In this review, we start from the basic principles of excited‐state dynamics provide a thorough comprehension main pathways photothermal conversion in nanocrystals. Aspects influencing effect such as lanthanide‐doping concentration, particle size, crystal structure fully discussed. Hybrid strategies design efficient lanthanide‐based agents, including dye sensitization to break absorption limit semiconductor combination add cross‐relaxation pathways, also summarized. Furthermore, highlight cutting‐edge applications nanoplatforms optical diagnosis temperature feedback photothermia‐associated Lastly, current challenges future efforts clinical are proposed. This review is expected offer better understanding mechanisms inspire efforts designing versatile theranostic nanoplatforms.

Язык: Английский

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Fe3+-DOX-Mediated Self-Assembled Nanolipids for Tumor Microenvironment Activated Synergistic Ferroptotic-Chemo Therapy Assisted with MR-imaging

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 415, С. 136039 - 136039

Опубликована: Май 26, 2024

Язык: Английский

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