Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 409 - 409
Опубликована: Март 25, 2025
Colorectal
cancer
poses
a
significant
threat
to
human
health
due
its
high
aggressiveness
and
poor
prognosis.
Key
factors
impacting
patient
outcomes
include
post-surgical
recurrence,
chemotherapeutic
drug
resistance,
insensitivity
immunotherapy.
Consequently,
early
diagnosis
the
development
of
effective
targeted
therapies
are
essential
for
improving
prevention
treatment
strategies.
Inorganic
nanomaterials
have
gained
prominence
in
colorectal
owing
their
unique
size,
advantageous
properties,
modifiability.
Various
types
inorganic
nanomaterials—such
as
metal-based,
metal
oxide,
quantum
dots,
magnetic
nanoparticles,
carbon-based,
rare-earth
nanomaterials—have
demonstrated
potential
enhancing
multimodal
imaging,
delivery,
synergistic
therapies.
These
advancements
underscore
critical
role
therapeutic
outcomes.
This
review
highlights
properties
nanomaterials,
summarizes
recent
applications
progress
treatment,
discusses
challenges
translating
these
materials
into
clinical
use.
It
aims
provide
valuable
insights
future
research
application
management.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Abstract
Intracellular
delivery
of
biomacromolecules
is
critical
for
advancements
in
cell‐based
therapy,
genome
editing,
regenerative
medicine,
and
basic
biological
research.
Recent
developments
vertically
aligned
micro/nanoneedle
arrays
(MNNs)
have
shown
significant
promise
localized
controlled
intracellular
by
efficiently
overcoming
barriers
to
access
the
cytosol.
Progress
both
vitro
vivo
applications
reflects
potential
MNNs
transition
from
proof‐of‐concept
therapeutic
tools.
This
review
systematically
summarizes
recent
domains,
highlighting
as
highly
efficient,
universal,
scalable
vehicles.
The
discussion
begins
detailing
innovative
materials
structural
features
that
enhance
their
capabilities.
followed
an
exploration
how
varying
material
characteristics,
surface
chemistry,
external
forces
facilitate
penetration
across
cellular
barriers,
alongside
breakthroughs
understanding
debated
mechanisms
underlying
MNNs‐mediated
delivery.
Additionally,
interactions
between
engineered
dynamic
tissue
analyzing
role
facilitating
macromolecular
vivo,
are
discussed.
Finally,
a
brief
overview
existing
challenges
future
prospects
concerning
improvements
preclinical
provided.
aims
bridge
micro/nanotechnology
cell
biology,
advancing
laboratory
research
toward
practical
life
sciences.
With
the
increasing
presence
of
nanoplastics
(NPs)
in
human
bloodstream,
it
is
urgent
to
investigate
their
tissue
accumulation
and
potential
health
risks.
This
study
examines
effects
size
surface
charges
polystyrene
(PS)
NPs
on
lung
accumulation.
Using
magnetic
separation,
we
identified
protein
corona
composition
iron-core
PS
NPs,
revealing
enrichment
vitronectin
fibrinogen.
The
promotes
integrin
α
