Design and development of Dasatinib nanoemulsions for ocular delivery: In vitro characterization, biocompatibility, and Ex vivo ocular irritation study DOI

Richa Khadke,

Amol Shete,

Akanksha Dashawant

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125504 - 125504

Опубликована: Март 1, 2025

Язык: Английский

Engineered Neutrophil Nanovesicles for Inhibiting Corneal Neovascularization by Synergistic Anti‐Inflammatory, Anti‐VEGF, and Chemoexcited Photodynamic Therapy DOI Open Access
Xiaoxue Liu, Yang Bi,

Chaoqun Wei

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Corneal neovascularization (CorNV) develops under various pathological conditions and is one of the main causes blindness. Due to that CorNV progression involves multiple steps, anti-vascular endothelial growth factor (VEGF) drugs alone could not sufficiently suppress this process, highlighting an urgent need for efficient delivery system multi-step management CorNV. In study, a neutrophil nanovesicle-based eye drop (NCCR) developed therapy simultaneously inhibits angiogenesis inflammation, while eliminating cells through chemoexcited photodynamic (PDT). NCCR targets inflammatory lesions by leveraging expression chemokine receptors from source cells. Then, exerts inhibitory effects on sequential steps neovascularization. First, it acts as decoy anti-inflammatory effect neutralizing cytokines via its surface nanovesicles. Second, thioketals bond-linked ranibizumab released in high reactive oxygen species microenvironment sites bind VEGF, inhibiting vascular cell activation proliferation. Finally, PDT eliminates preformed corneal blood vessels, disrupting tube formation pericyte recruitment. The synergistic combined with induction apoptosis neovessels PDT, offer novel strategy treatment.

Язык: Английский

Процитировано

0

Construction of a thermosensitive gel based on hydroxypropyl-β-cyclodextrin/meloxicam inclusion complexes for improving meloxicam solubility and prolonging drug retention time in the cornea DOI

Lvyao Yang,

Xiu’e Li,

Yuanke Zhang

и другие.

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

0

Treatment of glaucoma with drug-loaded contact lenses: a systematic review and meta-analysis DOI Creative Commons
Diya Zhang, Cong Ren, Xuan Wang

и другие.

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177425 - 177425

Опубликована: Фев. 1, 2025

This study is a systematical review regarding the glaucoma treatment with drug-loaded contact lenses. The effectiveness and safety about that were summarized, which providing effective suggestions guidance for clinical research. studies published up to May 1, 2024 on of sustained-release lenses searched from CNKI, Wanfang Data, VIP, PubMed, Embase, Cochrane Library, Medline. CAMARADES was used evaluate literature quality. safety, endpoints intraocular pressure reduction (IOPR) duration (IOP) decline during analyzed by means qualitative quantitative methods. protocol registration number CRD42024487157. 47 included. In trials, patients showed 50% in IOP no corneal tissue destruction after wearing animal experiments, endpoint IOPR [MD=0.58, 95%CI (0.37, 0.80), P<0.00001] medicated group significantly better than eye drops group. Subgroup analysis loaded timolol (TML), TML + dorzolamide, latanoprost, compared drops, had effect reducing IOP, while puerarin, bimatoprost statistical difference. Most demonstrated drugs release vitro ≥3 days treatment. exhibit excellent safety. nanoparticle-loaded containing recommended future

Язык: Английский

Процитировано

0

Zinc–gallic acid–polylysine nanocomplexes with enhanced bactericidal activity for the treatment of bacterial keratitis DOI Creative Commons
Kaijun Li, Zhang Ya, Kaihui Cheng

и другие.

e-Polymers, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 1, 2025

Abstract Bacterial keratitis is a common infectious eye disease. Conventional antibiotic drops are becoming less effective due to resistance. Herein, we design an innovative transition metal ion-based nano-delivery system for the treatment of bacterial keratitis. Zinc (Zn 2+ )–gallic acid–poly- l -lysine nanocomplex (ZGNC) designed by coordination interaction. ZGNC stable in physiological environment and can be dissociated acidic infected microenvironment. The positively charged effectively adhered onto cells subsequently realizes situ release Zn , leading much better bactericidal effect than free . Importantly, maintains excellent activity protein-rich environment, while completely invalid eradicate bacteria environment. vivo ability further confirmed murine model. This research provides promising method treat system.

Язык: Английский

Процитировано

0

Design and development of Dasatinib nanoemulsions for ocular delivery: In vitro characterization, biocompatibility, and Ex vivo ocular irritation study DOI

Richa Khadke,

Amol Shete,

Akanksha Dashawant

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125504 - 125504

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0