Physics in Medicine and Biology,
Год журнала:
2024,
Номер
69(14), С. 14TR02 - 14TR02
Опубликована: Июль 3, 2024
Functional
nanomaterials
have
emerged
as
versatile
nanotransducers
for
wireless
neural
modulation
because
of
their
minimal
invasion
and
high
spatiotemporal
resolution.
The
can
convert
external
excitation
sources
(e.g.
NIR
light,
x-rays,
magnetic
fields)
to
visible
light
(or
local
heat)
activate
optogenetic
opsins
thermosensitive
ion
channels
neuromodulation.
present
review
provides
insights
into
the
fundamentals
mostly
used
functional
in
neuromodulation
including
upconversion
nanoparticles,
nanoscintillators,
nanoparticles.
We
further
discussed
recent
developments
design
strategies
with
enhanced
energy
conversion
performance
that
greatly
expanded
field
summarized
applications
nanomaterials-mediated
techniques,
exciting/silencing
neurons,
modulating
brain
activity,
controlling
motor
behaviors,
regulating
peripheral
organ
function
mice.
Finally,
we
some
key
considerations
nanotransducer-mediated
along
current
challenges
future
directions.
Frontiers in Human Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 28, 2025
Neuromodulation,
the
targeted
regulation
of
nerve
activity,
has
emerged
as
a
promising
approach
for
treating
various
neurological
and
psychiatric
disorders.
While
deep
brain
stimulation
shown
efficacy,
its
invasive
nature
poses
substantial
risks,
including
surgical
complications
high
costs.
In
contrast,
non-invasive
neuromodulation
techniques,
particularly
those
utilizing
magnetic
fields
(MFs),
have
gained
increasing
attention
safer,
more
accessible
alternatives.
Magnetothermal
an
innovative
method
that
enables
precise
modulation
neuronal
ion
channels
through
localized
heating
induced
by
interaction
MF
with
biological
tissues.
This
review
discusses
principles
MF-based
highlights
critical
role
in
synaptic
transmission,
therapeutic
potential
these
advanced
techniques.
Additionally,
it
key
challenges
such
spatial
targeting
precision,
safety
considerations,
long-term
effects
exposure
on
function.
The
findings
presente
promise
non-invasive,
highly
strategy
conditions
epilepsy,
movement
disorders,
neurodegenerative
diseases,
applications
chronic
pain
management
future
clinical
interventions.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
Silica-based
materials
and
liposomes
are
widely
employed
in
drug
delivery
systems,
particularly
as
the
most
frequently
evaluated
platforms
for
intravenous
administration.
Their
exceptional
biocompatibility,
versatile
surface
modification
capabilities,
efficient
encapsulation
of
a
broad
spectrum
therapeutic
agents
make
them
ideal
targeted
controlled
delivery.
Both
nanodelivery
systems
interact
with
endothelial
cells
various
blood
components,
including
erythrocytes
(red
cells)
white
(lymphocytes,
monocytes,
macrophages),
potentially
leading
to
cytotoxic
effects.
However,
detrimental
impacts
silica
nanoparticles
(MSNs)
on
healthy
remain
insufficiently
investigated.
The
cytotoxicity
these
carriers
is
strongly
influenced
by
their
physicochemical
properties,
such
size,
charge,
functionalization,
well
specific
type
they
encounter.
This
review
aims
explore
molecular
cellular
dysfunctions
induced
MSNs
liposomes,
which
elicit
biological
responses,
proinflammatory
signaling,
oxidative
stress,
autophagy.
Considering
toxicity
associated
nanosilica
strategies
modifications
morphological
adjustments
may
serve
effective
approaches
mitigate
adverse
Implementing
holds
potential
develop
nanomaterials
lower
toxicological
profiles,
thereby
enhancing
safety
efficacy
clinical
applications.
By
addressing
challenges,
advancement
silica-based
can
be
optimized
safer
more
systems.
Journal of Neuroscience Methods,
Год журнала:
2025,
Номер
unknown, С. 110484 - 110484
Опубликована: Май 1, 2025
As
a
promising
neural
stimulation
technique,
infrared
(INS)
has
recently
gained
significant
attention
due
to
its
ability
stimulate
neuronal
activities
without
needing
exogenous
agents.
NIR
light
is
absorbed
by
water
of
the
tissue
producing
local
thermal
effects.
Therefore,
INS
suitable
candidate
for
localized
and
targeted
stimulation.
However,
despite
wide
variety
research
studies
on
applications,
limited
have
focused
identifying
optimizing
parameters
avoid
potential
excitotoxicity.
This
study
evaluates
dorsal
root
ganglia
(DRG)
neurons'
response
under
with
varying
intensities
illumination
time.
Here,
DRG
neurons
are
cultured
labeled
CamkII-GCaMP6s
virus.
The
were
exposed
laser
pulses
(2.01µm
wavelength,
different
powers
2.5mW,
5mW,
7.5mW,
10mW)
durations
300seconds
400seconds.
was
delivered
through
silica
optical
fiber
aligned
stabilized
within
free-space
setup.
Simultaneous
INS,
activity
evaluated
calcium
imaging
fluorescence
microscope.
method
allowed
real-time
monitoring
dynamics
conditions,
preparing
an
overview
safe
thresholds
INS.
It
found
that
saturation
happened
in
exposure
(7.5mW
300seconds,
representing
In
contrast,
same
time,
lower
(2.5mW
5mW)
did
not
show
signs
or
damage.
Moreover,
some
networks,
peripheral
illuminated
area
revealed
indirect
activation,
indicating
inter-neuronal
communication
Compared
previous
explored
use
neurons,
our
work
introduces
systematic
approach
evaluate
intensity-dependent
while
addressing
critical
issue
injury.
While
earlier
demonstrated
modulate
reduce
electrical
artifacts
electrophysiological
recordings,
concerns
regarding
excitotoxicity
damage
remain
insufficiently
investigated.
We
examined
range
determine
optimize
photothermal
impact.
Furthermore,
utilizing
CamKII-GCaMP6s
virus-modified
we
enhance
sensitivity
detecting
influx,
providing
more
precise
evaluation
responses
here,
provide
knowledge
identifies
required
parameters,
particularly
intensity
time
efficient
concluded
higher
can
cause
injury,
prolonged
exposure.
observed
activation
suggests
connections,
offering
further
insights
into
effects
networks.
These
findings
contribute
valuable
information
towards
neuromodulation
methods
clinical
settings.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Янв. 16, 2024
The
development
of
non-antibiotic
strategies
for
bacterial
disinfection
is
great
clinical
importance.
Among
recently
developed
different
antimicrobial
strategies,
nanomaterial-mediated
approaches,
especially
the
photothermal
way
and
reactive
oxygen
species
(ROS)-generating
method,
show
many
significant
advantages.
Although
promising,
application
nanomaterials
still
limited,
owing
to
potential
biosafety
issues.
Further
improvement
activity
reduce
usage,
thus
risk,
an
important
increase
applicability
antibacterial
nanomaterials.
In
this
paper,
nanostructure
with
both
excellent
effect
peroxidase-like
was
constructed
achieve
efficient
synergistic
activity.
obtained
nano-antimicrobial
agent
(ZIF-8@PDA@Pt)
can
not
only
efficiently
catalyze
production
ROS
from
H2O2
cause
damage
bacteria
but
also
convert
photon
energy
near-infrared
light
into
thermal
kill
bacteria,
two
effects
induced
in
a
highly
This
study
offers
new
nanomaterial
proposes
idea
constructing
properties.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 10, 2024
Abstract
Cancer
cells
exhibit
unique
bioelectrical
properties,
yet
therapeutic
strategies
exploiting
these
are
still
lacking.
Herein,
we
merge
a
nanobioelectronic
system
comprising
of
barium
titanate
nanoparticle
core
and
poly(3,4-ethylenedioxythiophene)
shell
(BTO@PEDOT
NPs)
with
cancer
to
modulate
bioelectricity.
We
hypothesize
that
the
BTO@PEDOT
NPs
act
as
nanoantenna,
transducing
mechanical
input
provided
by
external
ultrasound
(US)
stimulation
into
an
electrical
output,
capable
interfering
bioelectronic
circuitry
human
breast
cell
lines,
MCF-7
MDA-MB-231.
Upon
US
viability
MDA-MB-231
treated
200
µg
mL
-1
reduced
significantly
31%
24%,
respectively,
while
healthy
mammary
fibroblasts
were
unaffected
treatment
(94%
viability).
The
increased
ROS
levels
intracellular
Ca
2+
concentrations,
thus
promoting
apoptosis.
These
findings
underscore
potential
systems
emerging
promising
strategy
for
intervention
no
impact
on
cells.
ACS Nano,
Год журнала:
2024,
Номер
18(34), С. 22709 - 22733
Опубликована: Авг. 13, 2024
Natural
ion
channels
are
proteins
embedded
in
the
cell
membrane
that
control
many
aspects
of
and
human
physiology
by
acting
as
gatekeepers,
regulating
flow
ions
out
cells.
Advances
nanotechnology
have
influenced
methods
for
studying
