Physics in Medicine and Biology,
Год журнала:
2024,
Номер
69(14), С. 14TR02 - 14TR02
Опубликована: Июль 3, 2024
Functional
nanomaterials
have
emerged
as
versatile
nanotransducers
for
wireless
neural
modulation
because
of
their
minimal
invasion
and
high
spatiotemporal
resolution.
The
can
convert
external
excitation
sources
(e.g.
NIR
light,
x-rays,
magnetic
fields)
to
visible
light
(or
local
heat)
activate
optogenetic
opsins
thermosensitive
ion
channels
neuromodulation.
present
review
provides
insights
into
the
fundamentals
mostly
used
functional
in
neuromodulation
including
upconversion
nanoparticles,
nanoscintillators,
nanoparticles.
We
further
discussed
recent
developments
design
strategies
with
enhanced
energy
conversion
performance
that
greatly
expanded
field
summarized
applications
nanomaterials-mediated
techniques,
exciting/silencing
neurons,
modulating
brain
activity,
controlling
motor
behaviors,
regulating
peripheral
organ
function
mice.
Finally,
we
some
key
considerations
nanotransducer-mediated
along
current
challenges
future
directions.
Glioblastoma
(GBM)
with
highly
immunosuppressive
tumor
microenvironment
is
a
significant
factor
contributing
to
its
treatment
resistance
and
low
survival
rate.
The
activation
of
the
transient
receptor
potential
vanilloid
1
(TRPV1)
ion
channel,
which
overexpressed
on
endoplasmic
reticulum
(ER)
GBM
cells,
governs
control
multi-organelle
stress
pathway
branches
inhibit
expansion.
Precise
modulation
ER-TRPV1
considered
an
effective
strategy
for
inhibition
GBM.
As
intracellular
extracellular
second
messenger,
nitric
oxide
(•NO)
activates
TRPV1
channel
through
nitrosylation
cysteine
residues.
However,
short
lifespan
limited
range
•NO
makes
it
challenging
achieve
precise
regulation
ER-TRPV1.
Herein,
biomimetic
upconversion
nanoassembly
(M-UCN-T)
constructed,
encapsulates
organic
donor
coated
homologous
tumor-targeting
cell
membrane
ER-targeting
peptide.
In
response
near-infrared
light
glutathione,
M-UCN-T
releases
in
situ
activate
channels.
This
study
developed
•NO-targeted
release
nanoplatform
stepwise
targeting
functions,
allow
ER-TPRV1
•NO.
approach
induces
signaling
pathways,
ultimately
resulting
multi-modal
killing
cells.
ACS Materials Letters,
Год журнала:
2023,
Номер
6(2), С. 418 - 426
Опубликована: Дек. 28, 2023
Antibiotic
resistance
is
a
serious
global
health
concern.
Here,
we
designed
novel
class
of
bactericidal
nanoparticles,
pyrimidine
derivative-capped
gold
nanoparticles
(MP-AuNPs)
with
12
nm,
exhibiting
prominent
antibacterial
activity
against
Pseudomonas
aeruginosa
4-log
reduction
and
2-log
Staphylococcus
aureus
cells
within
1
h.
We
demonstrated
that
MP-AuNPs
appeared
to
be
transported
across
the
bacterial
cell
wall
in
an
energy-dependent
way
via
potassium
ion
(K+)
channels,
thus
affecting
transmembrane
proteins
ultimately
causing
depolarization
membrane
destruction
envelope,
leading
death.
Internalized
not
cause
significant
DNA
fragmentation
or
measurable
imbalance
cell's
redox
state.
In
this
case,
damage
was
caused
by
intracellular
lipid
peroxidation
exhibited
good
biocompatibility
mammalian
cells.
These
findings
reveal
previously
unknown
mechanism
associated
provide
potential
avenue
for
developing
new
therapies.
Digest Journal of Nanomaterials and Biostructures,
Год журнала:
2023,
Номер
18(3), С. 933 - 939
Опубликована: Июль 1, 2023
Scandium
and
Niobium
doped
Lithium
Titanate
is
prepared
by
a
sol-gel
technique
based
on
the
formula
Li
4-x
Sc
x
Ti
5-y
Nb
y
O
12
,
where
=
0.0
&
0.3
i.e.Li
4
5
3.7
4.7
.The
specific
capacity
of
incorporated
LTO
has
been
observed
as
227.5
mAhg
-1
at
1
c,
while
this
value
shown
decrease
in
electrode
i.e.
105.5
20
c
even
after
many
test
cycles.It
also
that
Sc-Nb
doping
suitable
for
reversible
cycle
battery
system
extraction
+
.
Physics in Medicine and Biology,
Год журнала:
2024,
Номер
69(14), С. 14TR02 - 14TR02
Опубликована: Июль 3, 2024
Functional
nanomaterials
have
emerged
as
versatile
nanotransducers
for
wireless
neural
modulation
because
of
their
minimal
invasion
and
high
spatiotemporal
resolution.
The
can
convert
external
excitation
sources
(e.g.
NIR
light,
x-rays,
magnetic
fields)
to
visible
light
(or
local
heat)
activate
optogenetic
opsins
thermosensitive
ion
channels
neuromodulation.
present
review
provides
insights
into
the
fundamentals
mostly
used
functional
in
neuromodulation
including
upconversion
nanoparticles,
nanoscintillators,
nanoparticles.
We
further
discussed
recent
developments
design
strategies
with
enhanced
energy
conversion
performance
that
greatly
expanded
field
summarized
applications
nanomaterials-mediated
techniques,
exciting/silencing
neurons,
modulating
brain
activity,
controlling
motor
behaviors,
regulating
peripheral
organ
function
mice.
Finally,
we
some
key
considerations
nanotransducer-mediated
along
current
challenges
future
directions.
