In vivo fluorescence imaging of nanocarriers in near-infrared window II based on aggregation-caused quenching

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 14, 2024

Accurate fluorescence imaging of nanocarriers in vivo remains a challenge owing to interference derived mainly from biological tissues and free probes. To address both issues, the current study explored fluorophores near-infrared (NIR)-II window with aggregation-caused quenching (ACQ) properties improve accuracy. Candidate NIR-II emission, ACQ984 (λem = 984 nm) IR-1060 1060 nm), aza-BODIPY cyanine families, respectively, were compared commercial fluorophore ICG tail emission NIR-I P2 family. demonstrates high water sensitivity complete at fraction greater than 50%. Physically embedding illuminates various nanocarriers, while cause negligible ACQ effect. Imaging based on revealed fine structures vascular system resolution. Moreover, good ex correlations monitoring blood can be established, enabling real-time noninvasive situ investigation pharmacokinetics dynamic distribution tissues. also has effect, but lack sufficient photostability steady post-labeling undermines its potential for nanocarrier bioimaging. an excellent only provides nondiscriminative ambiguous images. The failure non-ACQ probe display biodistribution details serves as counterevidence improved accuracy by Taken together, it is concluded that probes enables accurate bioimaging pharmacokinetic analysis.

Язык: Английский

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Engineering of exosome-liposome hybrid-based theranostic nanomedicines for NIR-II fluorescence imaging-guided and targeted NIR-II photothermal therapy of subcutaneous glioblastoma

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114258 - 114258

Опубликована: Сен. 19, 2024

Язык: Английский

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A promising mesoporous silica carrier material for the diagnosis and treatment of liver diseases: recent research advances

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The therapeutic diagnosis of liver diseases has garnered significant interest within the medical community.

Язык: Английский

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Translational nanorobotics breaking through biological membranes

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

In the dynamic realm of translational nanorobotics, endeavor to develop nanorobots carrying therapeutics in rational vivo applications necessitates a profound understanding biological landscape human body and its complexity. Within this landscape, membranes stand as critical barriers successful delivery therapeutic cargo target site. Their crossing is not only challenge for nanorobotics but also pivotal criterion clinical success therapeutic-carrying nanorobots. Nevertheless, despite their urgency, strategies membrane remain relatively underrepresented scientific literature, signaling an opportunity further research innovation. This review focuses on with various propulsion mechanisms from chemical physical hybrid mechanisms, it identifies describes four essential that represent needed be crossed journey applications. First entry point into blood stream, which skin or mucosa intravenous injection; next exit bloodstream across endothelium site; cell through plasma and, finally, escape lysosome, otherwise destroys cargo. The discusses design challenges inherent translating nanorobot technologies real-world provides overview documented crossings. aim underscore need interdisciplinary collaborations between chemists, materials scientists biologists vital domain has potential revolutionize field precision medicine.

Язык: Английский

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A novel prostate cancer-specific fluorescent probe based on extracellular vesicles targeting STEAP1 applied in fluorescence guided surgery

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 199 - 218

Опубликована: Фев. 5, 2025

Язык: Английский

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