Applied Materials Today, Год журнала: 2024, Номер 37, С. 102110 - 102110
Опубликована: Фев. 28, 2024
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125254 - 125254
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 249, С. 125993 - 125993
Опубликована: Июль 27, 2023
Язык: Английский
Процитировано
31
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Язык: Английский
Процитировано
16
Nanoscale, Год журнала: 2023, Номер 15(44), С. 17658 - 17697
Опубликована: Янв. 1, 2023
Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via blocking DNA topoisomerase 1.
Язык: Английский
Процитировано
19
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)
Опубликована: Фев. 7, 2024
Abstract High reactive oxygen species (ROS) levels in tumor microenvironment (TME) impair both immunogenic cell death (ICD) efficacy and T activity. Furthermore, escapes immunosurveillance via programmed death‐1/programmed ligand‐1 (PD‐L1) signal, the insufficient intracellular hydrogen peroxide weakens ferroptosis efficacy. To tackle above issues, a glutathione (GSH)/ROS/pH triple‐responsive prodrug nanomedicine that encapsulates Fe 2 O 3 nanoparticle electrostatic interaction is constructed for magnetic resonance imaging (MRI)‐guided multi‐mode theranostics with chemotherapy/ferroptosis/immunotherapy. The diselenide bond consumes ROS TME to increase cells ICD efficacy, cleavage of which facilitates PD‐L1 antagonist D peptide release block immune checkpoint. After internalization, released acidic endosome MRI simultaneously lipid peroxides generation ferroptosis. Doxorubicin cleaved from polymers condition high GSH level accompanied by ICD, potentiates NADPH oxidase mediated H self‐generation. In vivo results indicate nanoplatform strengthens induces cytotoxic lymphocytes proliferation, inhibits 4T1 regression metastasis, prolongs survival median. all, new strategy proposed strengthening activity cascade as well checkpoint blockade effective immunotherapy.
Язык: Английский
Процитировано
7
Pharmacology & Therapeutics, Год журнала: 2024, Номер 256, С. 108605 - 108605
Опубликована: Фев. 16, 2024
Язык: Английский
Процитировано
6
Nano Letters, Год журнала: 2024, Номер 24(11), С. 3548 - 3556
Опубликована: Март 8, 2024
After spinal cord injury (SCI), successive systemic administration of microtubule-stabilizing agents has been shown to promote axon regeneration. However, this approach is limited by poor drug bioavailability, especially given the rapid restoration blood–spinal barrier. There a pressing need for long-acting formulations in treating SCI. Here, we conjugated antioxidant idebenone with paclitaxel create heterodimeric paclitaxel–idebenone prodrug via an acid-activatable, self-immolative ketal linker and then fabricated it into chondroitin sulfate proteoglycan-binding nanomedicine, enabling retention within at least 2 weeks notable enhancement hindlimb motor function regeneration after single intraspinal administration. Additional investigations uncovered that can suppress activation microglia neuronal ferroptosis, thereby amplifying therapeutic effect paclitaxel. This prodrug-based nanomedicine simultaneously accomplishes neuroprotection regeneration, offering promising strategy
Язык: Английский
Процитировано
6
ACS Central Science, Год журнала: 2024, Номер 10(7), С. 1371 - 1382
Опубликована: Июнь 21, 2024
Radiotherapy is commonly used to treat cancer, and localized energy deposited by radiotherapy has the potential chemically uncage prodrugs; however, it been challenging demonstrate prodrug activation that both sustained in vivo truly tumors without affecting off-target tissues. To address this, we developed a series of novel phenyl-azide-caged, radiation-activated chemotherapy drug-conjugates alongside computational framework for understanding corresponding pharmacokinetic pharmacodynamic (PK/PD) behaviors. We especially focused on an albumin-bound monomethyl auristatin E (MMAE) found blocked tumor growth mice, delivered 130-fold greater amount activated drug irradiated versus unirradiated tissue, was 7.5-fold more efficient than non prodrug, showed no appreciable toxicity compared free or cathepsin-activatable drugs. These data guided modeling action, which indicated extended pharmacokinetics can improve cumulative activation, payloads with low vascular permeability diffusivity particularly patients receiving daily treatments conventional weeks. This work thus offers quantitative PK/PD proof-of-principle experimental demonstration how extending circulation its activity vivo.
Язык: Английский
Процитировано
6
Materials Advances, Год журнала: 2024, Номер 5(11), С. 4634 - 4659
Опубликована: Янв. 1, 2024
This review focuses on updates regarding a broad spectrum of fabrication advances and applications in the field prodrug-based nanotechnologies multiple cancer therapeutic strategies response to tumor microenvironment.
Язык: Английский
Процитировано
5
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(31)
Опубликована: Июнь 17, 2024
Depot-type drug delivery systems are designed to deliver drugs at an effective rate over extended period. Minimizing initial "burst" can also be important, especially with causing systemic toxicity. Both goals challenging small hydrophilic molecules. The of molecules such as the ultrapotent local anesthetic tetrodotoxin (TTX) exemplifies both challenges. Toxicity mitigated by conjugating TTX polymers ester bonds, but slow hydrolysis result in subtherapeutic release. Here, we developed a prodrug strategy, based on dynamic covalent chemistry utilizing reversible reaction between diol and phenylboronic acids. These polymeric prodrugs exhibited encapsulation efficiencies exceeding 90 % resulting nanoparticles showed range release rates. In vivo injection sciatic nerve reduced toxicity produced block lasting 9.7±2.0 h, comparison 1.6±0.6 h from free TTX. This approach could used co-deliver dexamethasone, which prolonged 21.8±5.1 h. work emphasized usefulness for depot-type kinetics.
Язык: Английский
Процитировано
4