Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 199, С. 114991 - 114991
Опубликована: Июль 4, 2023
Язык: Английский
Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 409 - 409
Опубликована: Март 25, 2025
Colorectal cancer poses a significant threat to human health due its high aggressiveness and poor prognosis. Key factors impacting patient outcomes include post-surgical recurrence, chemotherapeutic drug resistance, insensitivity immunotherapy. Consequently, early diagnosis the development of effective targeted therapies are essential for improving prevention treatment strategies. Inorganic nanomaterials have gained prominence in colorectal owing their unique size, advantageous properties, modifiability. Various types inorganic nanomaterials—such as metal-based, metal oxide, quantum dots, magnetic nanoparticles, carbon-based, rare-earth nanomaterials—have demonstrated potential enhancing multimodal imaging, delivery, synergistic therapies. These advancements underscore critical role therapeutic outcomes. This review highlights properties nanomaterials, summarizes recent applications progress treatment, discusses challenges translating these materials into clinical use. It aims provide valuable insights future research application management.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 25, 2024
Global mortality data indicates cancer as the second-leading cause of death worldwide. Therefore, there's a pressing need to innovate effective treatments address this significant medical and societal challenge. In recent years, X-ray-induced photodynamic therapy (X-PDT) has emerged promising advancement, revolutionizing traditional (PDT) for deeply entrenched malignancies by harnessing penetrating X-rays external stimuli. Recent developments in X-ray have shown trend toward minimizing radiation doses remarkably low levels after proof-of-concept demonstration. Early detection real-time monitoring are crucial aspects treatment. Sophisticated imaging techniques been enhanced introduction luminescence nano-agents, alongside contrast nanomaterials based on attenuation. luminescence-based vivo offers excellent sensitivity superior image quality deep tissues at reasonable cost, due unhindered penetration unimpeded auto-fluorescence X-rays. This review emphasizes significance responsive theranostics, exploring their mechanism action, feasibility, biocompatibility, prospects imaging-guided deep-seated tumors. Additionally, it discusses applications X-PDT treating breast cancer, liver lung skin colorectal cancer.
Язык: Английский
Процитировано
3
Biomedicines, Год журнала: 2024, Номер 12(1), С. 90 - 90
Опубликована: Янв. 1, 2024
The global statistics of bone disorders, skeletal defects, and fractures are frightening. Several therapeutic strategies being used to fix them; however, RNAi-based siRNA therapy is starting prove be a promising approach for the prevention disorders because its advanced capabilities deliver or drug conjugate target tissue. Despite 'bench-to-bedside' usefulness approval by food administration five siRNA-based medicines: Patisiran, Vutrisiran, Inclisiran, Lumasiran, Givosiran, use other diseases still remains resolved. By correcting complications complexities involved in delivery sustained release, better absorption, toxicity-free activity, can harnessed as an experimental tool complex undruggable with personalized medicine approach. present review summarizes findings notable research address implications health restoration mass, recovery loss, recuperation fractures.
Язык: Английский
Процитировано
2
ChemNanoMat, Год журнала: 2024, Номер 10(7)
Опубликована: Май 3, 2024
Abstract Hybrid nanocomposites integrating nanostructured zinc oxide (ZnO) and carbon quantum dots (CQDs) with designed heterostructures possess exceptional optical electronic properties. These properties hold immense potential for advancements across diverse scientific technological fields. This review article investigates the synthesis, properties, applications of ZnO‐CQD heterostructure nanocomposites. Recent breakthroughs in fabrication methods are examined, including hydrothermal, microwave‐assisted, eco‐friendly techniques. Key preparation such as sol‐gel, co‐precipitation, electrochemical deposition discussed, emphasizing their role controlling formation. analyses impact on fluorescence, photoluminescence, photocatalytic activity. Synergistic interactions between ZnO CQDs within highlighted, demonstrating how they lead to substantial performance improvements. Applications span solar cells, LEDs, photodetectors, water purification, antimicrobial treatments, gas sensing, catalysis, biomedical imaging, drug delivery, environmental energy storage. Insights provided into refining synthesis methods, enhancing characterisation techniques, broadening application landscape. Challenges like stability addressed, along strategies optimised practical implementation. comprehensive offers a thorough understanding nanocomposites, emphasising significance materials science engineering. By addressing core concepts future directions, it lays foundation continued innovation this dynamic field.
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Окт. 4, 2024
Abstract Exposure to nanoparticles (NPs) is frequently associated with adverse cardiovascular effects. In contrast, NPs in nanomedicine hold great promise for precise lung‐specific drug delivery, especially considering the extensive pulmonary capillary network that facilitates interactions bloodstream‐suspended particles. Therefore, exact knowledge about effects of engineered within microcirculation are instrumental future application this technology patients. To unravel real‐time dynamics intravenously delivered and their microvasculature, we employed intravital microscopy mouse lung. Only PEG‐amine‐QDs, but not carboxyl‐QDs triggered rapid neutrophil recruitment microvessels subsequent alveolar space was linked cellular degranulation, TNF‐α, DAMP release into circulation, particularly eATP. Stimulation ATP‐gated receptor P2X7R induced expression E‐selectin on microvascular endothelium thereby mediating neutrophilic immune response. Leukocyte integrins LFA‐1 MAC‐1 facilitated adhesion decelerated crawling vascular surface. summary, study unravels complex cascade during NP‐induced sterile inflammation. Thereby demonstrate novel provide critical insights optimizing NP‐based delivery therapeutic intervention strategies, ensure efficacy safety clinical applications.
Язык: Английский
Процитировано
1
Polymer Engineering and Science, Год журнала: 2024, Номер 64(4), С. 1534 - 1547
Опубликована: Янв. 18, 2024
Abstract The study aimed to develop a potential biomaterial for neuroregeneration by the electrospinning of biocompatible polymer polyvinylidene fluoride (PVDF) with innovative functionalized boron nitride quantum dots (F‐BNQDs) synthesized via green chemistry using amino acid taurine as functionalization. F‐BNQDs were characterized and found be 16–21 nm in diameter, showed good photoluminescent characteristics, their elemental composition was confirmed x‐ray photoelectron spectroscopy, Fourier‐transform infrared (FTIR), ultraviolet spectroscopy. PVDF prepared at three different concentrations, resulting electrospun fibers scanning electron microscopy, FTIR, thermogravimetric analysis, contact angle, biodegradation, water uptake, Schwann cell cytotoxicity, behavior studies. results that addition resulted enhanced mechanical properties, decreased increased degradability, uptake. lactate dehydrogenase assay revealed 5% BN‐PVDF had lowest cytotoxicity. Fluroscent 4',6‐diamidino‐2‐phenylindole (DAPI) staining increase F‐BNQD concentration up on fibers. Therefore, concluded would suitable further testing vivo. Highlights Functionalized taurine. (PVDF). incorporation has its physicochemical properties. All samples single βphase PVDF. cells excellent compatibility adhesion F‐BNQDs/PVDF.
Язык: Английский
Процитировано
0
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 38, С. 101106 - 101106
Опубликована: Март 2, 2024
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 13 - 42
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(13), С. e33868 - e33868
Опубликована: Июль 1, 2024
The influence of two nanostructured osteoplastic materials with different compositions: i) alginate (Alg) matrix, loaded Zn2+ ions and hydroxyapatite (HA) - S1/HA-Zn, ii) chitosan (CS) matrix brushite nanoparticles (NPs, dicalcium phosphate dihydrate, DCPD) S2/DCPD on the healing an experimental femoral diaphysis defect was investigated. structure cellular elements lacunar tubular system regenerated bone tissue were studied by electron microscopy. Osteogenic cells surface inside S1/HA-Zn formed tissue. On 30th day, latter had a reticulofibrous later lamellar structure. biomaterial integrated mainly into connective and, starting from 90th tissue, which only its outer surface. Thus, it has been proven that both biomaterials contribute to wounds. regenerative potential new formation prevails over S2/DCPD.
Язык: Английский
Процитировано
0
The Analyst, Год журнала: 2024, Номер 149(17), С. 4322 - 4342
Опубликована: Янв. 1, 2024
Biomedical silk protein optics has become the subject of intensive research aimed at solving challenges associated with traditional medical devices in terms biocompatibility and performance balance.
Язык: Английский
Процитировано
0