ACS Nano,
Год журнала:
2023,
Номер
17(22), С. 22334 - 22354
Опубликована: Окт. 2, 2023
As
a
major
late
complication
of
diabetes,
diabetic
peripheral
neuropathy
(DPN)
is
the
primary
reason
for
amputation.
Nevertheless,
there
are
no
wonder
drugs
available.
Regulating
dysfunctional
mitochondria
key
therapeutic
target
DPN.
Resveratrol
(RSV)
widely
proven
to
guard
mitochondria,
yet
unsatisfactory
bioavailability
restricts
its
clinical
application.
Tetrahedral
framework
nucleic
acids
(tFNAs)
promising
carriers
due
their
excellent
cell
entrance
efficiency,
biological
safety,
and
structure
editability.
Here,
RSV
was
intercalated
into
tFNAs
form
tFNAs-RSV
complexes.
achieved
enhanced
stability,
bioavailability,
biocompatibility
compared
with
alone.
With
treatment,
reactive
oxygen
species
(ROS)
production
minimized
reductases
were
activated
in
an
vitro
model
Besides,
respiratory
function
adenosine
triphosphate
(ATP)
enhanced.
also
exhibited
favorable
effects
on
sensory
dysfunction,
neurovascular
deterioration,
demyelination,
neuroapoptosis
DPN
mice.
Metabolomics
analysis
revealed
that
redox
regulation
energy
metabolism
two
principal
mechanisms
impacted
during
process.
Comprehensive
inspections
indicated
inhibited
nitrosation
oxidation
reductase
chain.
In
sum,
served
as
mitochondrial
nanoguard
(mito-guard),
representing
viable
drilling
drug
development
Nanomaterials,
Год журнала:
2025,
Номер
15(2), С. 133 - 133
Опубликована: Янв. 17, 2025
Doxorubicin
(DOX)
is
one
of
the
most
widely
used
chemotherapy
drugs
in
treatment
both
solid
and
liquid
tumors
patients
all
age
groups.
However,
it
likely
to
produce
several
side
effects
that
include
doxorubicin
cardiomyopathy.
Nanoparticles
(NPs)
can
offer
targeted
delivery
release
drug,
potentially
increasing
efficiency
alleviating
effects.
This
makes
them
a
viable
vector
for
novel
drug
systems.
Currently,
DOX
commonly
conjugated
NPs
by
non-covalent
conjugation-physical
entrapping
using
electrostatic
interactions,
van
der
Waals
forces,
or
hydrogen
bonding.
The
reported
downside
these
methods
they
provide
low
loading
capacity
higher
leakage
possibility.
In
comparison
this,
covalent
conjugation
via
amide
(typically
formed
coupling
carboxyl
groups
on
with
amine
nanoparticle
linker,
often
facilitated
carbodiimide
reagents),
hydrazone
(which
results
from
reaction
between
hydrazines
carbonyl
groups,
offering
pH-sensitive
cleavage
controlled
release),
disulfide
bonds
(formed
through
oxidation
thiol
cleavable
intracellular
reducing
agents
such
as
glutathione)
more
promising
offers
greater
bonding
strength.
review
covers
three
different
types
NPs-metallic,
silica/organosilica,
polymeric-including
their
corresponding
rates
mechanisms.
Coatings,
Год журнала:
2023,
Номер
13(9), С. 1660 - 1660
Опубликована: Сен. 21, 2023
This
review
focuses
on
the
surface
modification
of
metallic
nanoparticles
for
targeted
drug
delivery.
Metallic
nanoparticles,
owing
to
their
unique
size,
stability,
and
payload
capacity,
have
emerged
as
promising
carriers.
However,
application
necessitates
enable
precise
targeting.
Various
strategies,
such
polymer
coating
methods,
use
functional
groups,
bio-conjugation
with
targeting
ligands,
are
explored.
The
also
discusses
selection
ligands
based
target
receptors,
active
passive
approaches,
stimuli-responsive
It
further
delves
into
challenges
translating
these
strategies
clinical
settings,
including
scalability,
toxicity,
regulatory
hurdles.
is
a
avenue
coating,
functionalization
specific
bioconjugation
been
explored
enhance
therapeutic
potential
nanoparticles.
in
translation,
continuous
advancements
nanoparticle
synthesis,
techniques
offer
positive
outlook
future
systems.
Despite
delivery,
there
several
that
need
be
addressed
successful
translation.
These
include
scalable
fabrication
toxicity
concerns,
synthesis
expected
overcome
near
future.
Nanomaterials,
Год журнала:
2023,
Номер
13(21), С. 2887 - 2887
Опубликована: Окт. 31, 2023
Timely
diagnosis
and
appropriate
antitumoral
treatments
remain
of
utmost
importance,
since
cancer
remains
a
leading
cause
death
worldwide.
Within
this
context,
nanotechnology
offers
specific
benefits
in
terms
therapy
by
reducing
its
adverse
effects
guiding
drugs
to
selectively
target
cells.
In
comprehensive
review,
we
have
summarized
the
most
relevant
novel
outcomes
range
2010-2023,
covering
design
application
nanosystems
for
therapy.
We
established
general
requirements
nanoparticles
be
used
drug
delivery
strategies
their
uptake
tumor
microenvironment
vasculature,
including
reticuloendothelial
system
surface
functionalization
with
protein
corona.
After
brief
review
classes
nanovectors,
covered
different
therapies.
First,
advances
encapsulation
(such
as
paclitaxel
fisetin)
into
nanoliposomes
nanoemulsions
are
described,
well
relevance
current
clinical
trials.
Then,
polymeric
presented,
namely
ones
comprising
poly
lactic-co-glycolic
acid,
polyethylene
glycol
(and
PEG
dilemma)
dendrimers.
The
quantum
dots
bioimaging
is
also
covered,
systems
zinc
sulfide
indium
phosphide.
Afterwards,
reviewed
gold
(spheres
anisotropic)
plasmon-induced
photothermal
iron
oxide
nanoparticles,
such
magnetite
maghemite,
has
been
analyzed
fields,
magnetic
resonance
imaging,
immunotherapy,
hyperthermia,
delivery.
Lastly,
recent
using
carbon
nanomaterials,
graphene
oxide,
nanotubes,
fullerenes,
dots.
Finally,
compared
passive
active
targeting
theranostics.
This
aims
(nano)mark
on
ongoing
journey
towards
realizing
remarkable
potential
realm
therapeutics.
Nanomaterials,
Год журнала:
2024,
Номер
14(5), С. 397 - 397
Опубликована: Фев. 21, 2024
The
wide
array
of
structures
and
characteristics
found
in
ZnO-based
nanostructures
offers
them
a
versatile
range
uses.
Over
the
past
decade,
significant
attention
has
been
drawn
to
possible
applications
these
materials
biomedical
field,
owing
their
distinctive
electronic,
optical,
catalytic,
antimicrobial
attributes,
alongside
exceptional
biocompatibility
surface
chemistry.
With
environmental
degradation
an
aging
population
contributing
escalating
healthcare
needs
costs,
particularly
developing
nations,
there's
growing
demand
for
more
effective
affordable
devices
with
innovative
functionalities.
This
review
delves
into
particular
essential
facets
different
synthetic
approaches
(chemical
green)
that
contribute
production
multifunctional
nano-ZnO
particles
applications.
Outlining
conjugation
ZnO
nanoparticles
highlights
enhancement
capacity
while
lowering
toxicity.
Additionally,
recent
progress
study
nano-biomaterials
tailored
purposes
is
explored,
including
biosensing,
bioimaging,
tissue
regeneration,
drug
delivery,
as
well
vaccines
immunotherapy.
final
section
focuses
on
particles'
toxicity
mechanism
special
emphasis
neurotoxic
potential,
primary
pathways,
providing
overall
up-to-date
development
future
perspectives
biomedicine
field.
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(3)
Опубликована: Янв. 8, 2024
Significant
challenges
persist
in
enhancing
the
delivery
efficiency
of
tumor
nanomedicines,
predominantly
due
to
difficulty
successfully
surpassing
pathophysiological
barriers.
Enhancing
penetration
nanomedicines
such
conditions
represents
a
pivotal
goal
advancing
anticancer
nanotherapeutics.
Transcytosis
emerges
as
promising
solution
this
context,
addressing
limitations
passive
drug
delivery.
By
harnessing
diverse
stimuli
induce
transcytosis,
nanocarriers
can
achieve
precise
and
deep
penetration,
resulting
high
therapeutic
efficacy
reduced
systemic
exposure
compound.
This
review
briefly
examines
various
stimuli‐responsive
nanosystems
offers
an
overview
outlook
on
development
for
transcytosis‐based
cancer
delivery,
aiming
provide
informative
insights
design
capable
tissue
enhanced
efficacy.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(3), С. 315 - 315
Опубликована: Фев. 28, 2024
Cancer
continues
to
pose
one
of
the
most
critical
challenges
in
global
healthcare.
Despite
wide
array
existing
cancer
drugs,
primary
obstacle
remains
selectively
targeting
and
eliminating
cells
while
minimizing
damage
healthy
ones,
thereby
reducing
treatment
side
effects.
The
revolutionary
approach
utilizing
nanomaterials
for
delivering
therapeutic
agents
has
significantly
enhanced
efficacy
safety
chemotherapeutic
drugs.
This
crucial
shift
is
attributed
unique
properties
nanomaterials,
enabling
nanocarriers
transport
tumor
sites
both
passive
active
modes,
drug
elimination
from
delivery
systems.
Furthermore,
these
can
be
designed
respond
internal
or
external
stimuli,
thus
facilitating
controlled
release.
However,
production
nanomedications
therapy
encounters
various
that
impede
progress
this
field.
review
aims
provide
a
comprehensive
overview
current
state
nanomedication
treatment.
It
explores
variety
focusing
on
their
are
overcoming
limitations
conventional
chemotherapy.
Additionally,
delves
into
functionalities
nanocarriers,
highlighting
significant
impact
evolution
nanomedicine.
also
critically
assesses
recent
advancements
systems,
covering
range
innovative
methodologies.
Finally,
succinctly
addresses
encountered
developing
nanomedications,
offering
insightful
perspectives
guide
future
research
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2629 - 2629
Опубликована: Сен. 18, 2024
Gene
therapy
is
the
technique
of
inserting
foreign
genetic
elements
into
host
cells
to
achieve
a
therapeutic
effect.
Although
gene
was
initially
formulated
as
potential
remedy
for
specific
problems,
it
currently
offers
solutions
many
diseases
with
varying
inheritance
patterns
and
acquired
diseases.
There
are
two
major
groups
vectors
therapy:
viral
vector
non-viral
therapy.
This
review
examines
role
macromolecule's
chemical
physical
architecture
in
delivery,
including
their
design
synthesis.
Polymers
can
boost
circulation,
improve
control
cargo
release
through
various
methods.
The
prominent
examples
discussed
include
poly-L-lysine,
polyethyleneimine,
comb
polymers,
brush
star
well
hydrogels
natural
polymers
modifications.
While
significant
progress
has
been
made,
challenges
still
exist
stabilization,
targeting
specificity,
cellular
uptake.
Overcoming
cytotoxicity,
improving
delivery
efficiency,
utilizing
hybrid
systems
vital
factors
prospects.
comprehensive
provides
an
illuminating
overview
field,
guiding
way
toward
innovative
non-viral-based
solutions.
