Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 198 - 198

Опубликована: Фев. 5, 2025

Tumor metastasis, the spread of cancer cells from primary site to distant organs, remains a formidable challenge in oncology. Central this process is involvement subcellular organelles, which undergo significant functional and structural changes during metastasis. Targeting these specific organelles offers promising avenue for enhanced drug delivery metastasis therapeutic efficacy. This precision increases potency reduces potential off-target effects. Moreover, by understanding role each organelle treatments can be designed disrupt metastatic at multiple stages, cell migration establishment secondary tumors. review delves deeply into tumor processes their connection with organelles. In order target biomembranes, cell-penetrating peptides, localization signal aptamers, small molecules, various other strategies have been developed. review, we will elucidate targeting look forward prospects domain.

Язык: Английский

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LocPro: a deep learning-based prediction of protein subcellular localization for promoting multi-directional pharmaceutical research

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101255 - 101255

Опубликована: Март 1, 2025

Язык: Английский

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Organelle-oriented nanomedicines in tumor therapy: Targeting, escaping, or collaborating?

Bioactive Materials, Год журнала: 2025, Номер 49, С. 291 - 339

Опубликована: Март 13, 2025

Язык: Английский

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Proteomics and machine learning-based approach to decipher subcellular proteome of mouse heart

Molecular & Cellular Proteomics, Год журнала: 2025, Номер unknown, С. 100952 - 100952

Опубликована: Март 1, 2025

Язык: Английский

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DNA Nanostructures for Rational Regulation of Cellular Organelles

JACS Au, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

DNA nanotechnology has revolutionized materials science and biomedicine by enabling precise manipulation of matter at the nanoscale. nanostructures (DNs) in particular represent a promising frontier for targeted therapeutics. Engineered DNs offer unprecedented molecular programmability, biocompatibility, structural versatility, making them ideal candidates advanced drug delivery, organelle regulation, cellular function modulation. This Perspective explores emerging role modulating behavior through organelle-targeted interventions. We highlight current advances nuclear, mitochondrial, lysosomal targeting, showcasing applications ranging from gene delivery to cancer For instance, have enabled precision mitochondrial disruption cells, pH modulation enhance silencing, nuclear gene-editing templates. While hold immense promise advancing nanomedicine, outstanding challenges include optimizing biological interactions addressing safety concerns. highlights potential rational control organelles, which could lead novel therapeutic strategies advancement nanomedicines future.

Язык: Английский

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Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature

Cell Reports, Год журнала: 2023, Номер 42(12), С. 113472 - 113472

Опубликована: Ноя. 24, 2023

Mitochondria are dynamic organelles that undergo fusion and fission events, in which the mitochondrial membrane DNA (mtDNA) play critical roles. The spatiotemporal organization of mtDNA reflects impacts dynamics. Herein, to study detailed dynamics mtDNA, we rationally develop a dual-color fluorescent probe, mtGLP, could be used for simultaneously monitoring via separate color outputs. By combining mtGLP with structured illumination microscopy monitor dynamics, discover formation nucleoid condensates damaged mitochondria. We further reveal promoted peripheral mitochondria asymmetric segregation. Through simulations, find events occurred when interacted highly curved regions at two ends Overall, show utilize maintain homeostasis.

Язык: Английский

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In situ visualization of the cellular uptake and sub-cellular distribution of mussel oligosaccharides

Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(6), С. 100932 - 100932

Опубликована: Янв. 4, 2024

Unlike chemosynthetic drugs designed for specific molecular and disease targets, active small-molecule natural products typically have a wide range of bioactivities multiple necessitating extensive screening development. To address this issue, we propose strategy the direct

Язык: Английский

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pH response mechanism of bifunctional fluorescent carbon quantum dots and application in cancer detection and bioself-targeting imaging

Journal of Molecular Structure, Год журнала: 2024, Номер 1308, С. 137939 - 137939

Опубликована: Март 9, 2024

Язык: Английский

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The interactions of subcellular organelles in pulmonary fibrosis induced by carbon black nanoparticles: a comprehensive review

Archives of Toxicology, Год журнала: 2024, Номер 98(6), С. 1629 - 1643

Опубликована: Март 27, 2024

Язык: Английский

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AI-driven precision subcellular navigation with fluorescent probes

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(43), С. 11054 - 11062

Опубликована: Янв. 1, 2024

Precise navigation within intricate biological systems is pivotal for comprehending cellular functions and diagnosing diseases. Fluorescent molecular probes, designed to target specific molecules, are indispensable tools this endeavor. This paper delves into the revolutionary potential of artificial intelligence (AI) in crafting highly precise effective fluorescent probes. We will discuss how AI can be employed to: design new subcellular dyes by optimizing physicochemical properties; prospective targeting probes based on receptors; quantitatively explore chemical laws molecules optimize optical properties probes; comprehensive probe guide construction multifunctional Additionally, we showcase recent AI-driven advancements development their successful biomedical applications, while addressing challenges outlining future directions towards transforming research, diagnostics, drug discovery.

Язык: Английский

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