Current Organic Chemistry,
Год журнала:
2024,
Номер
28(15), С. 1164 - 1178
Опубликована: Май 23, 2024
Abstract:
Recently,
pharmaceutical
industries
have
placed
considerable
emphasis
on
formulating
drug
delivery
systems
that
precisely
target
specific
sites,
optimize
utilization,
minimize
excipient
usage,
and
mitigate
side
effects.
Smart
polymers
hold
tremendous
promise
in
the
design
of
innovative
formulations
tailored
to
deliver
drugs
with
enhanced
precision,
efficacy,
therapeutic
benefits
while
minimizing
adverse
Within
delivery,
smart
demonstrate
exceptional
potential
achieving
controlled
targeted
release
profiles,
ensuring
receptors,
offtarget
This
comprehensive
review
article
focuses
latest
developments
polymers,
primarily
domains
delivery.
By
intelligently
responding
external
stimuli,
polymer-based
materials
offer
various
applications,
making
them
pivotal
modern
research.
utilizing
remarkable
attributes
researchers
industry
stakeholders
can
forge
a
path
toward
personalized,
efficient,
patient-centric
therapies
reduced
effects,
propelling
field
into
an
era
unprecedented
advancements.
ACS Nano,
Год журнала:
2024,
Номер
18(9), С. 6817 - 6844
Опубликована: Фев. 26, 2024
The
eye
contains
a
wealth
of
physiological
information
and
offers
suitable
environment
for
noninvasive
monitoring
diseases
via
smart
contact
lens
sensors.
Although
extensive
research
efforts
recently
have
been
undertaken
to
develop
sensors,
they
are
still
in
an
early
stage
being
utilized
as
intelligent
wearable
sensing
platform
various
biophysical/chemical
conditions.
In
this
review,
we
provide
general
introduction
lenses
that
developed
disease
therapy.
First,
different
biomarkers
available
from
the
ocular
summarized,
including
both
physical
chemical
biomarkers,
followed
by
commonly
used
materials,
manufacturing
processes,
characteristics
lenses.
Smart
eye-drug
delivery
with
advancing
technologies
achieve
more
efficient
treatments
then
introduced
well
latest
developments
diagnosis.
Finally,
sensor
communication
antimicrobial
other
emerging
bioapplications
also
discussed
challenges
prospects
future
development
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(17)
Опубликована: Фев. 26, 2024
As
an
indispensable
part
of
the
human
sensory
system,
visual
acuity
may
be
impaired
and
even
develop
into
irreversible
blindness
due
to
various
ocular
pathologies.
Among
diseases,
fundus
neovascularization
diseases
(FNDs)
are
prominent
etiologies
impairment
worldwide.
Intravitreal
injection
anti-vascular
endothelial
growth
factor
drugs
remains
primary
therapy
but
is
hurdled
by
common
complications
incomplete
potency.
To
renovate
current
therapeutic
modalities,
nanomedicine
emerged
as
times
required,
which
endowed
with
advanced
capabilities,
able
fulfill
effective
drug
delivery
achieve
precise
release
control,
thus
further
improving
effect.
This
review
provides
a
comprehensive
summary
advances
in
for
FND
management
from
state-of-the-art
studies.
First,
modalities
FNDs
thoroughly
introduced,
focusing
on
key
challenges
delivery.
Second,
nanocarriers
comprehensively
reviewed
posterior
based
nanostructures:
polymer-based
nanocarriers,
lipid-based
inorganic
nanoparticles.
Thirdly,
characteristics
microenvironment,
their
pathological
changes
during
FNDs,
corresponding
strategies
constructing
smart
elaborated.
Furthermore,
prospects
discussed.
Intravitreal
injections
of
antivascular
endothelial
growth
factor
(VEGF)
agents
are
the
primary
method
for
treating
retinal
vein
occlusion
(RVO).
However,
complex
structure
eye
anatomy
presents
ocular
barriers
that
impede
drug
delivery.
Additionally,
these
drugs
only
manage
complications
associated
with
RVO
and
fail
to
address
underlying
cause
vessel
occlusions.
Here,
we
describe
a
utilizes
functionalized
magnetically
driven
nanorobots
overcome
treat
RVO.
These
developed
using
hybrid
biomembrane
combines
stem
cell
membranes
liposome-derived
membranes,
enveloping
perfluorohexane,
iron
oxide
nanoparticles,
l-arginine.
After
intravitreal
injection,
can
move
directionally
through
penetrate
vitreous
body
reach
retina,
by
an
external
magnetic
field.
Subsequently,
actively
target
inflammation
sites
at
occluded
vessels
due
presence
membranes.
In
rat
model
RVO,
enhanced
targeting
accumulation
in
ischemic
were
demonstrated
following
injections.
Furthermore,
application
ultrasound
triggers
release
l-arginine
site
occlusion,
stimulating
production
nitric
oxide,
which
promotes
vasodilation
restores
blood
flow,
thereby
achieving
excellent
therapeutic
efficacy
We
believe
methods
hold
significant
promise
overcoming
challenges
delivery
effectively
clinical
applications.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101082 - 101082
Опубликована: Май 6, 2024
Hydrogel
presents
a
three-dimensional
polymer
network
with
high
water
content.
Over
the
past
decade,
hydrogel
has
developed
from
static
material
to
intelligent
controllable
response.
Various
stimuli
are
involved
in
formation
of
network,
among
which
photo-stimulation
attracted
wide
attention
due
advantages
conditions,
good
application
prospect
treatment
ophthalmic
diseases.
This
paper
reviews
photo-crosslink
hydrogels
ophthalmology,
focusing
on
types
and
their
applications
including
drug
delivery,
tissue
engineering
3D
printing.
In
addition,
limitations
future
prospects
also
provided.
Abstract
Choroidal
neovascularization
(CNV)
underlies
the
crux
of
many
angiogenic
eye
disorders.
Although
medications
that
target
vascular
endothelial
growth
factor
(VEGF)
are
approved
for
treating
CNV,
their
effectiveness
in
destroying
new
blood
vessels
is
limited,
and
invasive
intravitreal
administration
required.
Additionally,
other
drugs
destroy
established
neovessels,
such
as
combretastatin
A‐4,
may
have
systemic
side
effects
limit
therapeutic
benefits.
To
overcome
these
shortcomings,
a
two‐pronged
anti‐vascular
approach
presented
CNV
treatment
using
photoactivatable
nanoparticle
system
can
release
VEGF
receptor
inhibitor
disrupting
agent
when
irradiated
with
690
nm
light.
The
nanoparticles
be
injected
intravenously
to
enable
anti‐angiogenic
combination
therapy
through
light
irradiation
eyes.
This
potentiate
while
maintaining
favorable
biosafety
profile
choroidal
diseases.
Langmuir,
Год журнала:
2025,
Номер
41(5), С. 3007 - 3026
Опубликована: Янв. 31, 2025
Zwitterionic
hydrogels
have
emerged
as
a
highly
promising
class
of
biomaterials,
attracting
considerable
attention
due
to
their
unique
properties
and
diverse
biomedical
applications.
moieties,
with
balanced
positive
negative
charges,
endow
exceptional
hydration,
resistance
nonspecific
protein
adsorption,
low
immunogenicity
distinctive
molecular
structure.
These
facilitate
various
applications,
such
medical
device
coatings,
tissue
engineering,
drug
delivery,
biosensing.
This
review
explores
the
structure-property
relationships
in
zwitterionic
hydrogels,
highlighting
recent
advances
design
principles,
synthesis
methods,
structural
characteristics,
To
meet
evolving
growing
demand
for
field,
this
examines
current
challenges
future
research
directions
optimizing
multifunctional
hydrogels.
As
candidates
advanced
are
poised
address
critical
paving
way
improved
therapeutic
outcomes
broader
applicability
healthcare.
