Evaluation of perioperative routine coagulation testing versus thromboelastography for major liver resection – A single-arm, prospective, interventional trial (PORTAL trial) DOI Creative Commons
Reshma Ambulkar, V. Baskar, Shraddha Patkar

и другие.

Indian Journal of Anaesthesia, Год журнала: 2023, Номер 67(12), С. 1077 - 1083

Опубликована: Дек. 1, 2023

Background and Aims: The International Normalised Ratio (INR), which assesses the loss of procoagulant factors in extrinsic pathway, fails to evaluate coagulation abnormalities comprehensively after a major liver resection, often leads reduced synthesis anticoagulant-factors. This study was conducted with an aim trend compare results routine tests thromboelastography (TEG) during perioperative period patients undergoing resections (≥3 segments). Methods: Twenty-five who underwent resection were enrolled. prospective, single-arm, interventional performed primary objective determining serial changes conventional TEG resections, at preincision period, intraoperative postoperatively, 48 h on fifth postoperative day. Transfusion requirements blood components also assessed TEG-guided replacement strategy. Spearman rank-order correlation used relationships (both tests) each time point. Results: prothrombin (PT)-INR elevated 14 (56%) intraoperative, immediate 48-h points contrast parameters, remained normal all patients. Blood component transfusion avoided 4, 11 10 points, respectively. Conclusion: overestimates coagulopathy thromboelastography-guided strategy reduces overall requirements.

Язык: Английский

Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2) DOI
Shawn C. Owen, Juliane Nguyen

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 208, С. 115293 - 115293

Опубликована: Март 21, 2024

Язык: Английский

Процитировано

0
Evaluation of perioperative routine coagulation testing versus thromboelastography for major liver resection – A single-arm, prospective, interventional trial (PORTAL trial) DOI Creative Commons
Reshma Ambulkar, V. Baskar, Shraddha Patkar

и другие.

Indian Journal of Anaesthesia, Год журнала: 2023, Номер 67(12), С. 1077 - 1083

Опубликована: Дек. 1, 2023

Background and Aims: The International Normalised Ratio (INR), which assesses the loss of procoagulant factors in extrinsic pathway, fails to evaluate coagulation abnormalities comprehensively after a major liver resection, often leads reduced synthesis anticoagulant-factors. This study was conducted with an aim trend compare results routine tests thromboelastography (TEG) during perioperative period patients undergoing resections (≥3 segments). Methods: Twenty-five who underwent resection were enrolled. prospective, single-arm, interventional performed primary objective determining serial changes conventional TEG resections, at preincision period, intraoperative postoperatively, 48 h on fifth postoperative day. Transfusion requirements blood components also assessed TEG-guided replacement strategy. Spearman rank-order correlation used relationships (both tests) each time point. Results: prothrombin (PT)-INR elevated 14 (56%) intraoperative, immediate 48-h points contrast parameters, remained normal all patients. Blood component transfusion avoided 4, 11 10 points, respectively. Conclusion: overestimates coagulopathy thromboelastography-guided strategy reduces overall requirements.

Язык: Английский

Процитировано

0