Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 23, 2024
The
multi-biological
barriers
present
in
the
inflammatory
microenvironment
severely
limit
targeted
aggregation
of
anti-inflammatory
drugs
lesion
area.
However,
conventional
responsive
drug
carriers
inevitably
come
into
contact
with
several
pro-responsive
stimulatory
mediators
simultaneously,
leading
to
premature
release
and
loss
most
therapeutic
effects.
Breaking
through
multi-level
is
essential
improve
enrichment
bioavailability
drugs.
In
this
study,
we
propose
a
novel
two-stage
structural
strategy
build
shielded
cascades
nanocarriers
(FA-PTP@Que)
mediators,
using
cascade
structures
cross
multiple
environmental
barriers.
structure
FA-PTP@Que
exhibits
ideal
pathological
microenvironmental
response
properties.
has
shown
good
macrophage
regulation
effects
by
efficiently
targeting
macrophages,
scavenging
intracellular
reactive
oxygen
species
(ROS),
down-regulating
secretion
pro-inflammatory
factors.
Significantly,
mice
arthritis
colitis,
enriches
targets
macrophages
at
sites
showing
significant
combines
active
chemotaxis
tissues
effector
cells,
acting
precisely
each
barrier
level
different
microenvironments
responding
overcoming
microenvironment.
This
innovative
can
effectively
break
various
potential
application
other
diseases.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
Chronic
pancreatitis
(CP)
is
a
long‐standing
progressive
fibrosis
and
has
long
been
considered
incurable,
which
remains
heavy
health
burden
worldwide.
Mesenchymal
stem
cells
(MSCs)
with
anti‐fibrosis
properties
are
currently
used
in
the
treatment
of
fibroinflammatory
diseases.
However,
its
therapeutic
effect
limited
mainly
due
to
two
main
types
pathological
barriers
CP:
1)
Fibrotic
collagen
hinders
cell
delivery,
2)
Malignant
microenvironment
attacks
inactivation.
Here,
MSCs‐based
exogenous
nitric
oxide
(NO)
delivery
system
(MSCs‐Lip@RNO)
constructed.
In
MSCs‐Lip@RNO,
NO
not
only
can
be
booster
regulate
fibers,
relieve
vascular
compression
enhance
accumulation
MSCs
whole
pancreas,
but
also
form
protective
gas
layer
on
surface,
enhances
MSCs.
CP
rat
model,
pancreatic
injury
reduced
7
days
after
single
dose
administration
this
long‐acting
Collectively,
study
offers
promising
strategy
for
enhancing
efficacy
break
treatment.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
Inflammation
is
essential
for
pathogen
eradication
and
tissue
repair;
However,
chronic
inflammation
can
bring
on
multi‐organ
dysfunction
due
to
an
overproduction
of
reactive
oxygen
species
(ROS).
Among
various
anti‐inflammatory
agents,
polyphenol‐based
nanotherapeutics
offer
potential
advantages,
including
enhanced
stability,
targeted
delivery,
multiple
therapeutic
functions,
personalized
therapy
tailored
the
severity.
Despite
these
development
biocompatible
nanomedicines
capable
selective
accumulation
in
inflamed
tissues
efficient
inhibition
ROS‐induced
inflammatory
signaling
pathways
remains
a
considerable
challenge.
In
this
study,
novel
nanotherapeutic
engineered
through
temperature‐dependent
condensation
polyphenolic
catechin
facilitated
by
hydrothermal
reactions.
The
resulting
catechin‐condensed
(CCN150),
synthesized
at
relatively
low
temperature,
retains
physicochemical
functional
properties
akin
its
precursor,
catechin,
but
with
marked
enhancement
water
solubility.
CCN150
protects
cells
from
oxidative
stress
eliminating
intracellular
ROS
augmenting
antioxidant
enzymes.
vivo
studies
reveal
that
intravenously
administered
predominantly
accumulates
tissues,
minimal
distribution
healthy
regions.
Furthermore,
effectively
reduces
systemic
mouse
models
disrupting
cycles
instigated
pro‐inflammatory
milieu.
Exhibiting
negligible
toxicity,
holds
substantial
promise
extensive
applications
treatment
ROS‐mediated
diseases.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
Nanocatalytic
therapy
holds
significant
promise
in
cancer
treatment
by
exploiting
the
high
oxidative
stress
within
tumor
cells.
However,
efficiently
delivering
nanocatalytic
agents
to
tissues
and
maximizing
their
catalytic
activity
situ
remain
critical
challenges.
Morphology‐adaptive
delivery
systems,
capable
of
adjusting
physical
form
response
physiological
conditions,
offer
unique
spatiotemporal
control
for
navigating
complex
biological
environments
like
microenvironment.
While
designing
systems
that
undergo
multiple
shape
transformations
often
involves
stimuli‐responsive
mechanisms,
making
programmable
responses
through
simple
designs
highly
desirable
yet
challenging.
Here,
FeFKC,
an
innovative
adaptive
material
is
introduced
achieves
multi‐step
morphological
at
tissue
level
amplifies
a
straightforward
design.
As
microenvironmental
pH
decreases
during
drug
delivery,
FeFKC
dynamically
transitions
between
single
chains,
nanoparticles,
nanofibers.
This
shape‐shifting
facilitates
deep
penetration,
enhanced
cellular
uptake,
lysosomal
escape,
significantly
improving
its
efficiency
therapy.
In
vivo
studies
demonstrate
impressive
suppression
efficacy
up
95%
without
notable
biosafety
concerns.
The
findings
highlight
potential
nanomaterials
with
shape‐transforming
capabilities
overcome
barriers
enhance
therapy,
opening
new
avenues
other
diseases.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 23, 2024
The
multi-biological
barriers
present
in
the
inflammatory
microenvironment
severely
limit
targeted
aggregation
of
anti-inflammatory
drugs
lesion
area.
However,
conventional
responsive
drug
carriers
inevitably
come
into
contact
with
several
pro-responsive
stimulatory
mediators
simultaneously,
leading
to
premature
release
and
loss
most
therapeutic
effects.
Breaking
through
multi-level
is
essential
improve
enrichment
bioavailability
drugs.
In
this
study,
we
propose
a
novel
two-stage
structural
strategy
build
shielded
cascades
nanocarriers
(FA-PTP@Que)
mediators,
using
cascade
structures
cross
multiple
environmental
barriers.
structure
FA-PTP@Que
exhibits
ideal
pathological
microenvironmental
response
properties.
has
shown
good
macrophage
regulation
effects
by
efficiently
targeting
macrophages,
scavenging
intracellular
reactive
oxygen
species
(ROS),
down-regulating
secretion
pro-inflammatory
factors.
Significantly,
mice
arthritis
colitis,
enriches
targets
macrophages
at
sites
showing
significant
combines
active
chemotaxis
tissues
effector
cells,
acting
precisely
each
barrier
level
different
microenvironments
responding
overcoming
microenvironment.
This
innovative
can
effectively
break
various
potential
application
other
diseases.
