Deep eutectic solvents in analysis, delivery and chemistry of pharmaceuticals

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125278 - 125278

Опубликована: Янв. 1, 2025

Язык: Английский

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Optimized suction patch design for enhanced transbuccal macromolecular drug delivery

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 875 - 891

Опубликована: Фев. 19, 2025

Peptides represent a rapidly expanding class of drugs with broad therapeutic potential. However, due to their large molecular weight and susceptibility degradation in the gastrointestinal tract, most peptide are administered via subcutaneous (SC) injections. Despite extensive research, painless delivery platform for these is still lacking. Recently, an octopus-inspired buccal patch has shown promise addressing this challenge by leveraging synergistic combination mechanical stretching permeation enhancers. In study, loaded formulation were optimized improve ease use, scalability, efficacy. Through assessments properties, finite element simulations, ex vivo experiments, we evaluated effects design material, as well drug matrix composition preparation methods on performance. A > 9-fold larger effective surface area, produced mold casting medical-grade silicone (shore hardness 50) lyophilized matrix, emerged promising system. beagle dogs, 30-min application resulted 14.6 % bioavailability teriparatide (4118 g mol-1), while semaglutide (4114 mol-1) was 9.6 times higher than commercial tablet. This works showcases how systematic optimization technology can simplify administration macromolecular drugs, facilitating clinical translation non-invasive dosage form.

Язык: Английский

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Cannabidiol-Loaded Solid Lipid Nanoparticles Ameliorate the Inhibition of Proinflammatory Cytokines and Free Radicals in an In Vitro Inflammation-Induced Cell Model

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4744 - 4744

Опубликована: Апрель 26, 2024

Cannabidiol (CBD) is a non-psychoactive compound derived from Cannabis sativa. It has demonstrated promising effects in combating inflammation and holds potential as treatment for the progression of chronic inflammation. However, clinical application CBD limited due to its poor solubility bioavailability. This study introduces an effective method preparing CBD-loaded solid lipid nanoparticles (CBD-SLNs) using combination low-energy hot homogenization ultrasonication. We enhanced this process by employing statistical optimization with response surface methodology (RSM). The optimized CBD-SLN formulation utilizes glyceryl monostearate primary component nanocarrier. screened tool managing Stable, uniformly dispersed spherical size 123 nm, charge −32.1 mV, encapsulation efficiency 95.16%, drug loading 2.36% were obtained. CBD-SLNs exhibited sustained release properties, ensuring prolonged controlled delivery, which could potentially amplify therapeutic effects. Additionally, we observed that significantly reduced both reactive oxygen nitrogen species proinflammatory cytokines chondrocyte macrophage cell lines, these inhibitory being more pronounced than those free CBD. In conclusion, superiority over CBD, highlighting delivery system

Язык: Английский

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Synergistic effects of an amphiphilic drug(propranolol hydrochloride) with cationic surfactants in an aqueous medium: A physicochemical study

Journal of Molecular Liquids, Год журнала: 2024, Номер 408, С. 125327 - 125327

Опубликована: Июнь 22, 2024

Язык: Английский

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Fluid Mechanics in Food & Dairy Processing

Food engineering series, Год журнала: 2025, Номер unknown, С. 97 - 124

Опубликована: Янв. 1, 2025

Язык: Английский

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Advancements in Nanoemulsion-Based Drug Delivery Across Different Administration Routes

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 337 - 337

Опубликована: Март 5, 2025

Nanoemulsions (NEs) have emerged as effective drug delivery systems over the past few decades due to their multifaceted nature, offering advantages such enhanced bioavailability, protection of encapsulated compounds, and low toxicity. In present review, we focus on advancements in last five years across (trans)dermal, oral, ocular, nasal, intra-articular administration routes using NEs. Rational selection components, surface functionalization, incorporation permeation enhancers, functionalization with targeting moieties are explored for each route discussed. Additionally, apart from NEs, explore NE-based (e.g., gels) while highlighting emerging approaches vaccination theranostic applications. The growing interest NEs purposes is reflected clinical trials, which also By summarizing latest advances, exploring new strategies, identifying critical challenges, this review focuses developments efficient therapeutic approaches.

Язык: Английский

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An overview of oral bioavailability enhancement through self- emulsifying drug delivery systems

Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Introduction The pharmaceutical technologists face a lot of challenges and limitations when designing novel drug delivery systems such as low oral bioavailability many drugs, primarily due to poor solubility, slow dissolution rates, limited permeability through gastrointestinal mucosa, rapid degradation within the body. Areas covered: biopharmaceutical classification (BCS) represents map in research. Numerous active ingredients are characterized by water especially BCS class II IV. Self-emulsifying (SEDDS) could act game changer order overcome bioavailability. In this review, timelines representing launch self – emulsifying systems, their introduction platform benefits will be discussed detail.

Язык: Английский

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Green Synthesis, Bio-evaluation, and In Silico Study of Dibenzalacetone: A Curcumin Analog for The Medicinal Treatment of Inflammatory Diseases

Biocatalysis and Agricultural Biotechnology, Год журнала: 2025, Номер unknown, С. 103561 - 103561

Опубликована: Март 1, 2025

Язык: Английский

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Topical Ocular Drug Delivery: The Impact of Permeation Enhancers

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 447 - 447

Опубликована: Март 31, 2025

Topical ophthalmic drug delivery targeting the posterior segment of eye has become a key area interest due to its non-invasive nature, safety, ease application, patient compliance, and cost-effectiveness. However, achievement effective bioavailability in ocular is significant challenge unique barriers, including precorneal factors anatomical like cornea, conjunctiva, sclera. Successful systems require increased residence time improved corneal penetration enhance intraocular bioavailability. A promising strategy overcome these barriers incorporating enhancers (DPEs) into formulations. These compounds facilitate by improving permeability across otherwise impermeable or poorly permeable membranes. At level, they act through three primary mechanisms: breaking tear film stability interfering with mucous layer; disrupting membrane components such as phospholipids proteins; loosening epithelial cellular junctions. DPEs offer potential improve therapeutic outcomes, particularly for drugs eye. This review focused on analyzing current literature regarding use topical delivery, highlighting their mechanisms action revolutionize treatments.

Язык: Английский

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PEGylated terpesomes of curcumin for prominent hepatoprotective activity: fabrication, optimization, biochemical analysis and in vivo evaluation

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106876 - 106876

Опубликована: Апрель 1, 2025

Язык: Английский

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