Digestive
system
diseases,
such
as
gastritis,
gastric
ulcers,
chronic
liver
disease,
inflammatory
bowel
disease
(IBD),
and
colorectal
cancer,
represent
a
major
group
of
diseases
that
have
high
morbidity
death
rates
worldwide.
Their
incidence
continues
to
rise
owing
factors
dietary
structure
changes,
accelerated
lifestyles,
increased
environmental
pollution,
population
aging.
Despite
the
rapid
development
medical
technology,
treatment
digestive
still
faces
many
challenges,
addressing
drug-resistant
Helicobacter
pylori
infections,
treating
IBD,
improving
efficacy
advanced
gastrointestinal
tumor
therapies.
Fortunately,
emergence
drug-releasing
materials
has
provided
new
insights
can
be
used
in
disorders.
Drug-releasing
are
category
specially
designed
carriers
or
systems
capable
carrying
drugs
controlling
their
release
at
specific
time
intervals
on
demand
achieve
desired
therapeutic
effect.
This
article
reviews
recent
research
progress
diagnose
treat
First,
limitations
traditional
oral
drug
delivery
methods,
low
bioavailability
nonspecific
distribution,
discussed.
Second,
different
types
materials,
liposomes,
dendritic
polymers,
micelles,
nanogels,
inorganic
nanoparticles,
extracellular
vesicles,
along
with
advantages
terms
improved
stability,
biocompatibility,
targeting,
controlled
release,
outlined.
In
addition,
application
strategies
preclinical
findings
various
for
disorders
discussed
detail.
Review
could
help
researchers
explore
more
nanomaterials
personalized
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(9), С. 3876 - 3900
Опубликована: Июнь 22, 2024
Despite
the
promising
prospects
of
nanoparticles
in
oral
drug
delivery,
process
administration
involves
a
complex
transportation
pathway
that
includes
cellular
uptake,
intracellular
trafficking,
and
exocytosis
by
intestinal
epithelial
cells,
which
are
necessary
steps
for
to
enter
bloodstream
exert
therapeutic
effects.
Current
researchers
have
identified
several
crucial
factors
regulate
interaction
between
including
surface
properties
such
as
ligand
modification,
charge,
hydrophilicity/hydrophobicity,
protein
corona
formation,
well
holistic
like
particle
size,
shape,
rigidity.
Understanding
these
is
essential
enhancing
transepithelial
transport
efficiency
designing
effective
delivery
systems.
Therefore,
this
review
provides
comprehensive
overview
influence
nanoparticles,
elucidating
underlying
principles
governing
their
impact
on
transport.
The
also
outlines
chosen
parameters
be
considered
subsequent
design
RSC Advances,
Год журнала:
2025,
Номер
15(7), С. 5558 - 5570
Опубликована: Янв. 1, 2025
Background:
H.
pylori
is
recognized
as
one
of
the
main
causes
gastric
cancer,
and
this
type
cancer
considered
leading
diseases
causing
deaths
all
over
world.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(12), С. 5106 - 5131
Опубликована: Ноя. 2, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
(DDSs)
have
garnered
significant
attention
in
cancer
research
because
of
their
potential
for
precise
spatiotemporal
release
tailored
to
high
ROS
levels
within
tumors.
Despite
the
challenges
posed
by
distribution
heterogeneity
and
endogenous
supply
constraints,
this
review
highlights
strategic
alliance
ROS-responsive
DDSs
with
photodynamic
therapy
(PDT),
enabling
selective
leveraging
PDT-induced
enhanced
therapeutic
efficacy.
This
delves
into
biological
importance
progression
treatment.
We
elucidate
detail
operational
mechanisms
linkers,
including
thioether,
thioketal,
selenide,
diselencide,
telluride
aryl
boronic
acids/esters,
as
well
latest
developments
nanomedicines
that
integrate
PDT
strategies.
These
insights
are
intended
inspire
design
innovative
nanocarriers
PDT.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 238 - 238
Опубликована: Фев. 12, 2025
Metabolic
diseases
like
obesity
and
diabetes
are
on
the
rise,
therapies
with
biomacromolecules
(such
as
proteins,
peptides,
antibodies,
oligonucleotides)
play
a
crucial
role
in
their
treatment.
However,
these
drugs
traditionally
injected.
For
patients
chronic
(e.g.,
metabolic
diseases),
long-term
injections
accompanied
by
inconvenience
low
compliance.
Oral
administration
is
preferred,
but
delivery
of
challenging
due
to
gastrointestinal
barriers.
In
this
article,
we
introduce
available
biomacromolecule
for
treatment
diseases.
The
barriers
oral
drug
strategies
overcome
also
explored.
We
then
discuss
alleviating
defects,
including
glucose
metabolism,
lipid
energy
such
insulin,
glucagon-like
peptide-1
receptor
agonists,
proprotein
convertase
subtilisin/kexin
type
9
inhibitors,
fibroblast
growth
factor
21
analogues,
peptide
YY
analogues.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 25, 2025
Colorectal
cancer
(CRC)
remains
a
highly
heterogeneous
malignancy
with
significant
morbidity
and
mortality
worldwide.
Despite
advancements
in
surgery,
chemotherapy,
immunotherapy,
targeted
therapy,
treatment
efficacy
is
often
hampered
by
drug
resistance
systemic
toxicity.
In
recent
years,
nano-drug
delivery
systems
(NDDS)
have
emerged
as
promising
strategy
to
enhance
therapeutic
precision,
reduce
adverse
effects,
overcome
CRC
treatment.
This
review
discusses
the
NDDS
for
treatment,
focusing
on
optimization
of
oral
systems,
development
tumor-specific
targeting
strategies,
design
intelligent
responsive
tumor
microenvironment
(TME).
Furthermore,
we
summarize
current
challenges
translation
explore
future
research
directions
enhancing
their
clinical
feasibility
impact.
Deleted Journal,
Год журнала:
2024,
Номер
unknown, С. 01 - 10
Опубликована: Июль 19, 2024
The
growing
interest
in
nanoparticles
modern
research
is
due
to
their
potential
uses
different
fields
of
study.
Throughout
human
history,
individuals
have
been
exposed
environmental
nanosized
particles,
and
over
the
past
century,
these
exposures
significantly
risen.
Through
injection,
ingestion,
inhalation,
can
change
material's
physicochemical
characteristics
improve
its
ability
absorb
interact
with
biological
tissues.
Nanoparticles
penetrate
cell
membrane
reach
up
mitochondria
nucleus,
causing
gene
mutation
inhibiting
mitochondrial
process
involved
metabolism.
toxicity
associated
size,
shape,
charge,
surface
area,
chemical
composition,
other
linked
factors.
vivo
behavior
still
a
major
question
that
needs
be
resolved.
tests
are
performed
against
new
during
developmental
eliminate
or
ameliorate
identified
toxic
characteristics.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 9889 - 9919
Опубликована: Сен. 1, 2024
With
the
in-depth
knowledge
of
pathological
and
physiological
characteristics
intestinal
barrier-portal
vein/intestinal
lymphatic
vessels-systemic
circulation
axis,
oral
targeted
drug
delivery
is
frequently
being
renewed.
many
advantages,
such
as
high
safety,
convenient
administration,
good
patient
compliance,
researchers
have
begun
to
explore
from
intravenous
injections
administration.
Over
past
few
decades,
fields
materials
science
nanomedicine
produced
various
platforms
that
hold
great
potential
in
overcoming
multiple
barriers
associated
with
delivery.
However,
transport
particles
into
systemic
extremely
difficult
due
immune
rejection
biochemical
invasion
intestine,
which
limits
absorption
entry
bloodstream.
The
feasibility
drugs
sites
outside
gastrointestinal
tract
(GIT)
unknown.
This
article
reviews
biological
absorption,
vivo
fate
mechanisms
carriers,
theoretical
basis
for
impact
carrier
structural
evolution
on
administration
achieve
this
goal.
Finally,
different
nano-delivery
systems
can
enhance
bioavailability
therapeutics
highlights
their
applications
efficient
creation
anticancer
nanomedicines.
