Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer’s disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology, and amyloidogenesis

International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124218 - 124218

Опубликована: Май 9, 2024

Язык: Английский

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Amyloid-β-targeting immunotherapies for Alzheimer's disease

Journal of Controlled Release, Год журнала: 2024, Номер 375, С. 346 - 365

Опубликована: Сен. 18, 2024

Язык: Английский

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096

Опубликована: Сен. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

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Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer’s disease

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Intervention in chronically activated microglia-mediated neuroinflammation is a novel approach to treat Alzheimer's disease (AD). The low permeability of the blood‒brain barrier (BBB) and non-selective distribution brain severely restrict AD drugs' disease-modifying efficacy. Here, an immunosuppressant TREM2-lowing antisense oligonucleotides (ASOs) resveratrol co-loaded cationic liposome developed as immune reprogramming nanomodulator modified by acid-cleavable BBB-targeting peptide microglia-targeting (Res@TcMNP/ASO) for management. Res@TcMNP/ASO can enter endothelial cells via D-T7 peptides. Then undergoes acid-responsive cleavage, facilitating escape Res@MNP/ASO from endo/lysosomes cross BBB. detached specifically targets M1-phenotype microglia exposed MG1 peptides prompt simultaneous delivery two drugs into microglia. This not only restore function through ASO but also mitigate stimulation caused reactive oxygen species (ROS) resveratrol, thereby synergistically inhibiting chronic activation alleviate AD. Our results indicate that this combination treatment achieve significant behavioral cognitive improvements late APP/PS1 mice.

Язык: Английский

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Saccharomyces cerevisiae -derived Vesicles loaded with Dextromethorphan as a Candidate for the Management of Neuroinflammation related to Alzheimer’s Disease

Pharmaceutical Development and Technology, Год журнала: 2025, Номер unknown, С. 1 - 30

Опубликована: Фев. 27, 2025

Alzheimer's disease (AD) is a neurodegenerative that associated with neuroinflammation. Dextromethorphan (DXM) exerts neuroprotective effects in many central nervous system injuries and diseases. The cell wall of Saccharomyces cerevisiae cell-based drug delivery can be suitable candidate for targeted to the site inflammation. In this study, nanoparticles (NPs) were prepared from walls, coated polysorbate-80, loaded DXM. NPs had favorable hemolytic behavior particle size distribution 187.25 ± 73.37 nm zeta potential +4.3 mV. Pathological examination mouse model neuroinflammation showed ability reduce brain inflammation adverse

Язык: Английский

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Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine

Toxics, Год журнала: 2025, Номер 13(3), С. 178 - 178

Опубликована: Фев. 28, 2025

Billions of people are exposed to fine particulate matter (PM2.5) levels above the USEPA’s annual standard 9 μg/m3. Common emission sources anthropogenic, producing complex aerosolized toxins. Ultrafine (UFPM) and industrial nanoparticles (NPs) have major detrimental effects on brain, but USA does not measure UFPM a routine basis. This review focuses development progression common neurodegenerative diseases, as diagnosed through neuropathology, among young residents in Metropolitan Mexico City (MMC). MMC is one most polluted megacities world, with population 22 million residents, many whom unaware brain caused by their atmosphere. Fatal diseases (such Alzheimer’s Parkinson’s) that begin childhood populations living air environments preventable. We conclude UFPM/NPs capable disrupting neural homeostasis give rise relentless processes throughout entire life highly MMC. The paradigm reaching old age neurodegeneration no longer supported. Neurodegenerative changes start early pediatric ages irreversible. It time invest preventive medicine.

Язык: Английский

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Engineered nanoparticles for the treatment of Alzheimer’s disease

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 3, 2025

Alzheimer’s disease (AD) is one of the most common diseases characterized by neurodegeneration and becoming a major public health problem worldwide. AD manifested mainly progressive impairments in cognition, emotion, language memory elderly population. Many treatment strategies have been explored for decades; however, there still no effective way to address root cause pathogenesis, only target symptoms improve patient cognitive outcomes. Intracerebral administration difficult because challenges posed blood‒brain barrier (BBB). NPs are materials with sizes between 1 100 nm that can biocompatibility, extend half-life, transport macromolecules, be delivered across BBB central nervous system, exhibit good targeting capabilities. provide new ideas terms their antiaging, antineuroinflammatory, antioxidative, nerve repair-promoting effects. In this manuscript, we first describe relationship BBB. Second, introduce application nanoparticles treatment. Finally, summarize faced AD.

Язык: Английский

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Nanotechnological advancement for the treatment of neurodegenerative disorders

Journal of Dispersion Science and Technology, Год журнала: 2024, Номер unknown, С. 1 - 19

Опубликована: Ноя. 25, 2024

Язык: Английский

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Acid-assisted polysaccharides extracted from Asparagus cochinchinensis protect against Alzheimer’s disease by regulating the microbiota-gut-brain axis

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Дек. 18, 2024

In this study, an acid-assisted extraction strategy was used to extract a novel polysaccharide (ACP) from Asparagus cochinchinensis, after which purified and subjected extensive characterization. ACP determined have average molecular weight of 15,580 Da in structural characterization studies, it found primarily consist glucose, galactose, L-fucose, fructose at 82.14:12.23:2.61:2.49 ratio. Trace amounts xylose, arabinose, rhamnose were also detected preparations 0.48:0.04:0.02 GC–MS analyses identified eight different sugar linkages within ACP, including Glc p -(1→, →2)-Glc →6)-Glc →4)-Glc →3, 4)-Glc →2,4) -Gal →4,6)-Gal →3,4,6)-Gal -(1 → present 23.70:1.30:3.55:50.77:6.91:1.10:11.50:1.18 molar percent ratios. One-dimensional NMR, two-dimensional methylation ultimately revealed that the is mainly composed →4)- β -D-Glc small amount→4,6)- α -D-Gal →3,4)- so on. Branched chain α-D-Glc 4)- connected residues 4)-β-D-Glc O-4 position or O-3 position. treatment SAMP8 mice associated with reductions oxidative stress brain pathology together enhanced cognitive function. treated presented increases Bacteroidota abundance reduced Firmicutes, Patescibacteria, Actinobacteriota, Campilobacterota abundance. Thus, can prevent Alzheimer’s disease by modulating microbe-gut-brain axis.

Язык: Английский

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Nanomedicine biointeractions during body trafficking

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 209, С. 115324 - 115324

Опубликована: Апрель 23, 2024

Язык: Английский

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