Опубликована: Янв. 1, 2024
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1362 - 1362
Опубликована: Окт. 25, 2024
Cationic vaccines of nanometric sizes can directly perform the delivery antigen(s) and immunomodulator(s) to dendritic cells in lymph nodes. The positively charged nanovaccines are taken up by antigen-presenting (APCs) lymphatic system often originating cellular immunological defense required fight intracellular microbial infections proliferation cancers. molecules imparting positive charges exhibit a dose-dependent toxicity which needs be systematically addressed. Against coronavirus, mRNA cationic evolved rapidly. Nowadays have been formulated against several with advantage compounds granting protection nucleic acids vivo biodegradation nucleases. Up threshold concentration for nanovaccine delivery, well eliciting desired Th 1 improved immune response absence cytotoxicity. A second strategy literature involves dilution components biocompatible polymeric matrixes. Polymeric nanoparticles incorporating at reduced concentrations component result an toxic effects. progress vaccinology cancer situ designs nanovaccines. lysis transformed releases tumoral antigens, presence nanoadjuvants systemically presented prevention metastatic cancer. In addition, these local allow immunotherapeutic tumor treatment.
Язык: Английский
Процитировано
1
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 209, С. 115324 - 115324
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2024, Номер 9(41), С. 42410 - 42422
Опубликована: Окт. 1, 2024
Lactoferrin, an iron binding glycoprotein-based nanoparticle, has emerged as a promising platform for drug delivery and imaging. This study presents the potential use of protein nanocarrier in tracking sentinel lymph nodes cancer staging. Lactoferrin nanoparticles (LF-NPs) were synthesized using thermal treatment process optimized to obtain 60-70 nm particle size with PDI less than 0.2. The NPs characterized microscopically spectroscopically, ensuring comprehensive understanding their physicochemical properties. LF-NPs found be stable different pH conditions. Their biocompatibility was confirmed through cytotoxicity assessments on RAW 264.7 cells, hemolysis assay vivo toxicity reveal safe profile. Additionally, successfully radiolabeled technetium-99m (>90% labeling yield). Cell uptake studies exhibited ∼6%. Biodistribution Wistar rats shed light behavior suitability targeted systems. These findings collectively emphasize multifaceted utility LF-NPs, positioning them diverse biomedical innovations.
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110529 - 110529
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 5, 2024
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2024, Номер 16(23), С. 4039 - 4039
Опубликована: Дек. 2, 2024
Tumor growth and progression require molecular interactions between malignant host cells. In recent years, extracellular vesicles (EVs) emerged as an important pillar of such interactions, carrying information from their donor cells to distant recipient Thereby, the phenotype function are altered, which may facilitate tumor immune escape metastasis other organs through formation pre-metastatic niches. A prerequisite for these effects cell-derived EVs is efficient transport system site origin body periphery. Here, we highlight role lymphatic vascular in distribution progression-promoting functions EVs. Importantly, primary drainage interstitial fluid its soluble, particulate, cellular contents, therefore represents principal route regional (i.e., tumor-draining lymph nodes) systemic derived solid tumors. Furthermore, studies highlighted node a crucial where tumor-derived exert effects. deeper mechanistic understanding how gain access vasculature, they interact with nodes beyond, induce phenotypic functional maladaptation will be instrumental identify new targets conceive innovative approaches cancer therapy.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Дек. 18, 2024
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by painful swelling and inflammation, arising from the immune system attacking on healthy cells. However, arthritic sites often experience increased lymph flow, hastening drug clearance potentially reducing treatment effectiveness. To address this challenge, in situ size amplification has been proposed to reduce lymphatic thereby enhance therapy. This developed based a conjugate of dexamethasone (Dex) polysialic acid (PSA), linked via acid-sensitive linker, supplemented with bis-5-hydroxytryptamine (Bis-5HT) PSA backbone. Under physiological conditions, autonomously assembles into stable nanoparticles (PD5NPs), facilitating prolonged circulation targeted delivery inflamed joints. Upon arrival at joints, Bis-5HT reacts elevated myeloperoxidase (MPO) levels oxidative stress, prompting particle aggregation in-situ amplification. nanocarrier effectively reduces serves as reservoirs for sustained Dex release acidic pH environments within sites, thus continuously alleviating RA symptoms. Moreover, investigation underlying mechanism elucidates how influences transportation PD5NPs joints vessels. Our study offers valuable insights optimizing nanomedicine performance vivo augmenting therapeutic efficacy.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0