Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis
ACS Nano,
Год журнала:
2024,
Номер
18(42), С. 28866 - 28880
Опубликована: Окт. 11, 2024
Sepsis
is
characterized
by
a
dysregulated
immune
response
and
very
difficult
to
treat.
In
the
cecal
ligation
puncture
(CLP)
mouse
model,
we
show
that
nanomedicines
can
effectively
alleviate
systemic
local
septic
events
targeting
neutrophils.
Specifically,
decorating
surface
of
clinical-stage
dexamethasone
liposomes
with
cyclic
arginine-glycine-aspartic
acid
(cRGD)
peptides,
promote
their
engagement
neutrophils
in
circulation,
leading
prominent
accumulation
at
primary
secondary
sepsis
sites.
cRGD-targeted
potently
reduce
immature
circulating
neutrophil
extracellular
traps
intestinal
induction
sites
liver.
Additionally,
they
mitigate
inflammatory
cytokines
systemically
locally
while
preserving
IL-10
levels,
contributing
lower
IFN-γ/IL-10
ratios
as
compared
control
free
dexamethasone.
Our
strategy
addresses
cellular
level,
illustrating
use
both
therapeutic
target
chariot
for
drug
delivery.
Язык: Английский
Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing
Journal of Molecular Liquids,
Год журнала:
2024,
Номер
unknown, С. 126541 - 126541
Опубликована: Ноя. 1, 2024
Язык: Английский
Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 6, 2025
Neutrophil
extracellular
traps
(NETs)
participate
in
both
host
defense
and
the
pathogenesis
of
various
diseases,
such
as
infections,
thrombosis,
tumors.
While
they
help
capture
eliminate
pathogens,
NETs'
excessive
or
dysregulated
formation
can
lead
to
tissue
damage
disease
progression.
Therapeutic
strategies
targeting
NET
modulation
have
shown
potential,
but
challenges
remain,
particularly
achieving
precise
drug
delivery
maintaining
stability.
Nanoparticle
(NP)-based
systems
offer
innovative
solutions
for
overcoming
limitations
conventional
therapies.
This
review
explores
biological
mechanisms
formation,
their
interactions
with
NPs,
therapeutic
applications
NP-based
modulating
NETs.
We
discuss
how
NPs
be
designed
either
promote
inhibit
provide
a
comprehensive
analysis
potential
treating
NET-related
diseases.
Additionally,
we
address
current
future
prospects
therapies
research,
aiming
bridge
gap
between
nanotechnology
development
novel
approaches.
Язык: Английский
The emerging role of neutrophil extracellular traps in autoimmune and autoinflammatory diseases
MedComm,
Год журнала:
2025,
Номер
6(3)
Опубликована: Март 1, 2025
Neutrophil
extracellular
traps
(NETs)
are
unique
fibrous
structures
released
by
neutrophils
in
response
to
various
pathogens,
exhibiting
both
anti-inflammatory
and
proinflammatory
effects.
In
autoimmune
conditions,
NETs
serve
as
crucial
self-antigens
triggering
inflammatory
cascades
activating
the
inflammasome
complement
systems,
disrupting
self-tolerance
mechanisms
accelerating
responses.
Furthermore,
play
a
pivotal
role
modulating
immune
cell
activation,
affecting
adaptive
This
review
outlines
intricate
relationship
between
diseases,
including
arthritis,
systemic
Behçet's
disease,
lupus
erythematosus,
kidney
skin
sclerosis,
vasculitis,
gouty
arthritis.
It
highlights
potential
of
targeting
therapeutic
strategy
diseases.
By
examining
dynamic
balance
NET
formation
clearance
this
offers
critical
insights
theoretical
foundation
for
future
research
on
NET-related
mechanisms.
Advances
systems
biology,
flow
cytometry,
single-cell
multiomics
sequencing
have
provided
valuable
tools
exploring
molecular
NETs.
These
advancements
renewed
focus
offering
promising
avenues
further
investigation
into
their
clinical
implications.
Язык: Английский
Neutrophils in Type 1 Diabetes: Untangling the Intricate Web of Pathways and Hypothesis
Biomolecules,
Год журнала:
2025,
Номер
15(4), С. 505 - 505
Опубликована: Март 31, 2025
Neutrophils
are
increasingly
recognized
as
key
contributors
to
the
pathogenesis
of
Type
1
Diabetes
(T1D),
yet
their
precise
mechanistic
role
in
disease
onset
and
progression
remains
incompletely
understood.
While
these
innate
immune
cells
reside
pancreatic
tissue
support
homeostasis
under
physiological
conditions,
they
can
also
drive
damage
by
triggering
responses
modulating
inflammation.
Within
inflammatory
milieu,
neutrophils
establish
complex,
bidirectional
interactions
with
various
cells,
including
macrophages,
dendritic
natural
killer
lymphocytes.
Once
activated,
may
enhance
response
through
direct
or
indirect
crosstalk
antigen
presentation,
β-cell
destruction
dysfunction.
These
mechanisms
underscore
multifaceted
dynamic
T1D,
shaped
intricate
immunological
interactions.
Further
research
into
diverse
functional
capabilities
is
crucial
for
uncovering
novel
aspects
involvement
potentially
revealing
new
therapeutic
targets
modulate
progression.
Язык: Английский
Neutrophil hitchhiking liposomal drugs for starvation therapy in endometriosis
Theranostics,
Год журнала:
2025,
Номер
15(10), С. 4848 - 4860
Опубликована: Март 31, 2025
Rationale:
Endometriosis,
characterized
by
the
presence
of
ectopic
endometrial-like
tissue,
is
a
common
chronic
inflammatory
disorder
in
gynecology.
However,
current
treatments,
including
surgery
and
hormone
therapy,
often
yield
suboptimal
outcomes
significant
adverse
effects.
The
lack
drug
delivery
system
specifically
targeting
lesions
remains
major
barrier
to
development
more
effective
treatments.
Methods:
To
exploit
continuous
recruitment
neutrophils
elevated
reactive
oxygen
species
(ROS)
levels
within
endometriotic
lesions,
we
designed
ROS-responsive
liposome
(cLipo)
modified
with
neutrophil-targeting
peptides
on
its
surface.
A
minimally
invasive
mouse
model
endometriosis
was
used
assess
neutrophil-mediated
cLipo.
Additionally,
co-loaded
glucose
analog
2-deoxy-D-glucose
(2-DG)
autophagy
inhibitor
chloroquine
(CQ)
into
liposomes,
resulting
formulation
termed
cLipo-DC.
therapeutic
efficacy
cLipo-DC
evaluated
using
human
cells
(12Z),
endometrial
cancer
(Ishikawa),
an
model.
Results:
Although
neutrophil
hitchhiking
strategies
are
rarely
reported
diseases,
found
that
cLipo
bound
accumulated
following
intraperitoneal
injection
Subsequently,
vitro
experiments
showed
effectively
inhibited
glycolysis
both
12Z
Ishikawa
cells,
cell
death.
Furthermore,
vivo
administration
exerted
anti-endometriosis
effect,
no
detectable
side
Conclusions:
This
study
provides
novel
platform
for
non-hormonal
treatment
endometriosis.
Язык: Английский
Rod‐shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
Abstract
Neutrophilic
inflammation
is
present
in
numerous
high‐mortality
pathologies,
including
sepsis,
deep
vein
thrombosis,
and
acute
lung
injury
(ALI).
Therefore,
regulating
neutrophil
recruitment
becomes
an
attractive
therapeutic
approach
for
neutrophil‐mediated
inflammation.
Here,
the
impact
of
salicylic
acid‐based
polymeric
particles
vivo
vitro,
particularly
investigating
targeting
via
particle
geometry‐driven
phagocytosis
explored.
It
found
that
rod‐shaped
can
improve
a
murine
ALI
model,
effectively
preventing
infiltration
into
mice's
lungs
compared
to
spherical
same
volume.
demonstrated
elongated
nature
carriers
reduced
neutrophils’
transmigration
ability
across
endothelial
barriers
contributing
their
effectiveness.
These
data
represent
initial
work
developing
non‐spherical
particle‐mediated
activated
neutrophils
conditions
affected
by
neutrophilic
injury.
Язык: Английский