Insights from animal studies exploring the efficacy and safety of topical losartan, in prophylaxis and treatment of corneal scarring fibrosis

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 183, С. 117857 - 117857

Опубликована: Янв. 17, 2025

Язык: Английский

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TGF-β-Based Therapies for Treating Ocular Surface Disorders

Cells, Год журнала: 2024, Номер 13(13), С. 1105 - 1105

Опубликована: Июнь 26, 2024

The cornea is continuously exposed to injuries, ranging from minor scratches deep traumas. An effective healing mechanism crucial for the restore its structure and function following major insults. Transforming Growth Factor-Beta (TGF-β), a versatile signaling molecule that coordinates various cell responses, has central role in corneal wound healing. Upon injury, TGF-β rapidly released into extracellular environment, triggering migration proliferation, differentiation of keratocytes myofibroblasts, initiation repair process. TGF-β-mediated processes are essential closure; however, excessive levels can lead fibrosis scarring, causing impaired vision. Three primary isoforms exist—TGF-β1, TGF-β2, TGF-β3. Although share many structural functional similarities, they present distinct roles regeneration, which adds an additional layer complexity understand Further, aberrant activity been linked pathologies, such as scarring Peter’s Anomaly. Thus, understanding molecular cellular mechanisms by TGF-β1-3 regulate will enable development potential therapeutic interventions targeting key this Herein, we summarize multifaceted healing, dissecting action interactions with other molecules, outline pathogenesis.

Язык: Английский

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Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126541 - 126541

Опубликована: Ноя. 1, 2024

Язык: Английский

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New insights into persistent corneal subepithelial infiltrates following epidemic keratoconjunctivitis: The first case report with ultrastructural and immunohistochemical investigations

Acta Histochemica, Год журнала: 2025, Номер 127(1), С. 152231 - 152231

Опубликована: Янв. 27, 2025

Язык: Английский

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Current Updates, Recent Trends and Future Directions of Gene Therapy on Various Eye Disorders

Indus journal of bioscience research., Год журнала: 2025, Номер 3(1), С. 500 - 508

Опубликована: Янв. 29, 2025

Gene therapy has emerged as a novel strategy in the treatment of eye problems, bringing fresh hope for illnesses previously believed to be untreatable. Recent developments molecular biology and genetic engineering have enabled creation tailored medicines that address fundamental causes ocular rather than just treating symptoms. interventions are showing promise conditions including diabetic retinopathy, age-related macular degeneration, hereditary retinal dystrophies. The area undergone revolution because methods like CRISPR-Cas9 gene editing adeno-associated viral (AAV) vectors, which enable precise delivery change material within protected limited environment eye. Patients receiving these treatments shown notable increases visual acuity structural repair clinical studies. Furthermore, order overcome obstacles immunogenicity payload capacity, next-generation systems nanoparticles non-viral vectors emerging, could increase potential therapy. Although field is still developing quickly, ethical concerns, high expenses, requirement long-term safety assessments major problems. This review highlights latest disorders, discussing key breakthroughs, ongoing trials, future directions achieve widespread accessibility efficacy diseases.

Язык: Английский

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Advanced 3D Materials for Corneal Stroma Regeneration: A Preclinical Progress

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Corneal stromal defects cause global blindness and entail unmet solutions beyond transplants. This review highlights scaffolds, biomaterials, signaling cues in corneal stroma engineering to advance next-generation vision therapies.

Язык: Английский

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Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 209, С. 115328 - 115328

Опубликована: Май 3, 2024

Язык: Английский

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TGF-β1-mediated upregulation of LMCD1 drives corneal myofibroblast differentiation and corneal fibrosis

Experimental Eye Research, Год журнала: 2024, Номер 249, С. 110130 - 110130

Опубликована: Окт. 18, 2024

Язык: Английский

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