Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
Recent
strides
in
non‐invasive
drug
delivery
have
spurred
innovation
alternatives
to
traditional
needle
injections.
Transdermal
systems
(TDDs)
emerged
as
a
particularly
promising
avenue,
boasting
minimal
rejection
rates,
user‐friendly
administration,
and
enhanced
patient
adherence.
Beyond
pharmaceuticals,
TDDs
show
potential
skincare
cosmetics,
leveraging
their
ability
facilitate
localized
while
minimizing
systemic
exposure.
Nonetheless,
the
intricate
physicochemical
nature
of
skin
presents
formidable
obstacles,
prompting
intensive
exploration
overcome
these
barriers.
This
comprehensive
review
delves
into
landscape
methodologies,
critically
analyzing
respective
advantages,
limitations,
characterization
prospective
applications.
advancements
underscore
robust
efficacy
TDDs,
positioning
it
versatile
indispensable
modality
poised
for
widespread
integration
across
multifarious
fields.
Язык: Английский
Virus-like particles: Innovative strategies for combatting emerging and re-emerging viral threats
The Microbe,
Год журнала:
2025,
Номер
unknown, С. 100351 - 100351
Опубликована: Апрель 1, 2025
Язык: Английский
Prominent Supramolecular Systems for Cancer Therapy: From Structural Design to Tailored Applications
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 117754 - 117754
Опубликована: Май 1, 2025
Язык: Английский
Cerebellar Pathology in Forensic and Clinical Neuroscience
Ageing Research Reviews,
Год журнала:
2025,
Номер
unknown, С. 102697 - 102697
Опубликована: Фев. 1, 2025
Язык: Английский
Extracellular vesicles for the delivery of gene therapy
Nature Reviews Bioengineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Язык: Английский
Investigating the kinetics of single-chain expansion upon release in theta conditions
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 5, 2025
The
free
expansion
of
a
confined
chain
in
theta
solvents
following
sudden
removal
the
confining
constraint
is
investigated
using
Langevin
dynamics
simulations
both
two-
and
three-dimensional
spaces.
average
evolution
size
exhibits
sigmoidal
transition
between
states
on
logarithmic
timescale,
indicating
two-stage
expansion,
each
characterized
by
its
own
timescale.
A
kinetic
theory
developed
applying
Onsager's
variational
principle,
which
balances
change
energy
with
dissipation.
Through
scaling
analysis,
characteristic
time
τ1
for
first
stage
shown
to
scale
as
cube
initial
size,
while
increases
according
power
law
an
exponent
α1=1/3
,
independent
spatial
dimension.
In
second
stage,
timescale
τ2
found
be
proportional
square
length,
follows
exponential
recovery
function
powered
α2=1/4
.
These
results
are
further
validated
direct
analysis
equations
via
simulations.
Moreover,
general
forms
two
stages
established
through
integration
equations.
Finally,
physical
interpretations
proposed,
employing
radial
model
diffusive
mechanism
explain
observed
behaviors.
This
work
explores
system
under
specific
solvent
condition,
providing
foundational
enhancing
our
understanding
expansion-upon-release
phenomenon.
Язык: Английский
mTORopathies in Epilepsy and Neurodevelopmental Disorders: The Future of Therapeutics and the Role of Gene Editing
Cells,
Год журнала:
2025,
Номер
14(9), С. 662 - 662
Опубликована: Апрель 30, 2025
mTORopathies
represent
a
group
of
neurodevelopmental
disorders
linked
to
dysregulated
mTOR
signaling,
resulting
in
conditions
such
as
tuberous
sclerosis
complex,
focal
cortical
dysplasia,
hemimegalencephaly,
and
Smith–Kingsmore
Syndrome.
These
often
manifest
with
epilepsy,
cognitive
impairments,
and,
some
cases,
structural
brain
anomalies.
The
pathway,
central
regulator
cell
growth
metabolism,
plays
crucial
role
development,
where
its
hyperactivation
leads
abnormal
neuroplasticity,
tumor
formation,
heightened
neuronal
excitability.
Current
treatments
primarily
rely
on
inhibitors,
rapamycin,
which
reduce
seizure
frequency
size
but
fail
address
underlying
genetic
causes.
Advances
gene
editing,
particularly
via
CRISPR/Cas9,
offer
promising
avenues
for
precision
therapies
targeting
the
mutations
driving
mTORopathies.
New
delivery
systems,
including
viral
non-viral
vectors,
aim
enhance
specificity
efficacy
these
therapies,
potentially
transforming
management
disorders.
While
editing
holds
curative
potential,
challenges
remain
concerning
delivery,
long-term
safety,
ethical
considerations.
Continued
research
into
mechanisms
innovative
may
pave
way
transformative,
personalized
patients
affected
by
complex
conditions.
Язык: Английский
Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Май 6, 2025
Different
cancers
remain
major
global
health
challenges
due
to
their
diverse
biological
behaviors
and
significant
treatment
hurdles.
The
aging
of
populations
lifestyle
factors
increase
cancer
occurrence
place
increasing
pressure
on
healthcare
systems.
Despite
continuous
advancements,
many
fatal
late-stage
diagnosis,
tumor
heterogeneity,
drug
resistance,
thus
necessitating
urgent
development
innovative
solutions.
Therapeutic
nucleic
acids,
a
new
class
drugs,
offer
promising
approach
overcoming
these
challenges.
recent
Nucleic
Acids
Nanobiosystems
in
Cancer
Theranostics
(NANCT)
conference
brought
together
internationally
recognized
experts
from
15
countries
discuss
cutting-edge
research,
spanning
oncolytic
viruses
anticancer
RNA
nanoparticles
other
emerging
nanotechnologies.
This
review
captures
key
insights
developments,
emphasizing
the
need
for
interdisciplinary
translation
scientific
advancements
into
clinical
practice
shaping
future
personalized
treatments
improved
therapeutic
outcomes.
Язык: Английский