Updates on the controversial roles of regulatory lymphoid cells in idiopathic pulmonary fibrosis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 25, 2024

Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of fibrosis, characterized by scar formation in lung interstitium. Transforming growth factor beta (TGF-β) known as a key mediator fibrotic process, acting on fibroblasts mediating their proliferation differentiation into myofibroblasts. Although immune system not considered responsible for initiation IPF, markers tolerogenic immunity define pro-fibrotic microenvironment lungs. In homeostatic conditions, regulatory T cells (Tregs) constitute main lymphoid population maintaining peripheral tolerance. Similar to Tregs, B (Bregs) represent recently described subset lymphocytes with immunosuppressive functions. context numerous studies have suggested role Tregs enhancing mainly via secretion TGF-β. humans, show increased percentages associated severity although exact remains unclear. mice, commonly used model involves triggering acute inflammation bleomycin, leading subsequent process. Consequently, data are still conflicting, may play protective during inflammatory phase deleterious phase. Bregs been less studied but appears be experimental models fibrosis. This review presents latest updates exploring implication IPF compares different approaches better understand origins conflicting findings.

Язык: Английский

Metagenomics combined with untargeted metabolomics to study the mechanism of miRNA-150-5p on SiO2 -induced acute lung injury

Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2024, Номер 252, С. 116515 - 116515

Опубликована: Окт. 10, 2024

Язык: Английский

Natural TPs inhibit biofilm formation by Multidrug-resistant Acinetobacter baumannii and biofilm-induced pulmonary inflammation

Microbial Pathogenesis, Год журнала: 2024, Номер unknown, С. 107172 - 107172

Опубликована: Ноя. 1, 2024

Язык: Английский