Mechanisms and pathology of protein misfolding and aggregation

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 24(12), С. 912 - 933

Опубликована: Сен. 8, 2023

Язык: Английский

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The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Nutrients, Год журнала: 2024, Номер 16(2), С. 308 - 308

Опубликована: Янв. 19, 2024

Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain-gut axis is an object that remains the target of modern research, it not without reason many enrich with diet in its name. Numerous connections mutual correlations have become basis for seeking answers questions pathology as well human physiology. Disorders this homeostasis dysbiosis itself accompany neurodegenerative diseases such Alzheimer's Parkinson's. Heavily dependent on external factors, modulation gut microbiome represents opportunity advance treatment Probiotic interventions, synbiotic or fecal transplantation can undoubtedly support biotherapeutic process. A special role played by diet, which provides metabolites directly affect body microbiota. holistic view organism therefore essential.

Язык: Английский

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Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer's disease

Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102210 - 102210

Опубликована: Фев. 1, 2024

Alzheimer's disease (AD) is a major global health problem today and the most common form of dementia. AD characterized by formation β-amyloid (Aβ) plaques neurofibrillary clusters, leading to decreased brain acetylcholine levels in brain. Another mechanism underlying pathogenesis abnormal phosphorylation tau protein that accumulates at level aggregates, areas affected this pathological process are usually cholinergic neurons cortical, subcortical, hippocampal areas. These effects result cognitive function, atrophy, neuronal death. Malnutrition weight loss frequent manifestations AD, these also associated with greater decline. Several studies have confirmed balanced low-calorie diet proper nutritional intake may be considered important factors counteracting or slowing progression whereas high-fat hypercholesterolemic predisposes an increased risk developing AD. Especially, fruits, vegetables, antioxidants, vitamins, polyunsaturated fatty acids, micronutrients supplementation exert positive on aging-related changes due their antioxidant, anti-inflammatory, radical scavenging properties. The purpose review summarize some possible contribute prevention understand role nutrition plays Aβ typical neurodegenerative disease, identify potential therapeutic strategies involve natural compounds, delaying disease.

Язык: Английский

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Gut microbiota and its metabolites in Alzheimer’s disease: from pathogenesis to treatment

PeerJ, Год журнала: 2024, Номер 12, С. e17061 - e17061

Опубликована: Март 13, 2024

Introduction An increasing number of studies have demonstrated that altered microbial diversity and function (such as metabolites), or ecological disorders, regulate bowel–brain axis involvement in the pathophysiologic processes Alzheimer’s disease (AD). The dysregulation microbes their metabolites can be a double-edged sword AD, presenting possibility microbiome-based treatment options. This review describes link between imbalances interactions AD modalities microbiota, potential interventions such prebiotics, probiotics, synbiotics, fecal microbiota transplantation, dietary complementary therapeutic strategies targeting pathogenesis progression. Survey methodology Articles from PubMed china.com on intestinal flora were summarized to analyze data conclusions carefully ensure comprehensiveness, completeness, accuracy this review. Conclusions Regulating gut balance upregulates neurotrophic factor expression, regulates microbiota-gut-brain (MGB) axis, suppresses inflammatory responses. Based emerging research, explored novel directions for future research clinical interventions, injecting new vitality into development.

Язык: Английский

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Gut instincts: Unveiling the connection between gut microbiota and Alzheimer's disease

Clinical Nutrition ESPEN, Год журнала: 2024, Номер 60, С. 266 - 280

Опубликована: Фев. 19, 2024

Язык: Английский

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Agmatine as a novel intervention for Alzheimer's disease: Pathological insights and cognitive benefits

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102269 - 102269

Опубликована: Март 11, 2024

Язык: Английский

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Roseburia intestinalis Supplementation Could Reverse the Learning and Memory Impairment and m6A Methylation Modification Decrease Caused by 27-Hydroxycholesterol in Mice

Nutrients, Год журнала: 2024, Номер 16(9), С. 1288 - 1288

Опубликована: Апрель 26, 2024

The abnormality in N6-methyladenosine (m6A) methylation is involved the course of Alzheimer’s disease (AD), while intervention 27-Hydroxycholesterol (27-OHC) can affect m6A modification brain cortex. Disordered gut microbiota a key link 27-OHC leading to cognitive impairment, and further studies have found that abundance Roseburia intestinalis significantly reduced under 27-OHC. This study aims investigate association 27-OHC, gut, learning memory ability injury. In this study, 9-month-old male C57BL/6J mice were treated with antibiotic cocktails for 6 weeks sweep intestinal flora, followed by or normal saline subcutaneous injection, then gavage applied mouse. level brain, barrier function, measured. From results, we observed impairs causing disturbance expression methylation-related enzymes reducing cortex, finally leads impairment. However, supplementation could reverse negative effects mentioned above. suggests 27-OHC-induced impairment might be linked disturbance, intestinalis, as probiotic great potential, damage caused research help reveal mechanism neural provide important scientific evidence future use neuroprotection.

Язык: Английский

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Trajectory of brain-derived amyloid beta in Alzheimer’s disease: where is it coming from and where is it going?

Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Авг. 19, 2024

Alzheimer's disease (AD) is a progressive neurological disorder that primarily impacts cognitive function. Currently there are no disease-modifying treatments to stop or slow its progression. Recent studies have found several peripheral and systemic abnormalities associated with AD, our understanding of how these alterations contribute AD becoming more apparent. In this review, we focuse on amyloid‑beta (Aβ), major hallmark summarizing recent findings the source brain-derived Aβ discussing where cleared in vivo. Based findings, propose future strategies for prevention treatment, from novel perspective metabolism.

Язык: Английский

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Psychobiotics and the gut-brain axis: advances in metabolite quantification and their implications for mental health

Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 20

Опубликована: Фев. 5, 2025

Psychobiotics are live microorganisms that, when administered in adequate amounts, confer mental health benefits to the host. Several clinical studies have demonstrated significant from psychobiotic administration, making them an emerging topic food science. Certain strains of Lactobacillus, Bifidobacterium, Streptococcus, Escherichia, and Enterococcus species known for their ability modulate gut-brain axis provide benefits. Proposed action mechanisms include production neuroactive compounds or precursors, which may cross blood-brain barrier, transported by extracellular vesicles. However, there is a lack vivo evidence directly confirming these mechanisms, although indirect recent suggest potential pathways further investigation. To advance our understanding, it crucial study within host, with accurate quantification and/or precursors being key such studies. Current methods, however, face challenges, as low sensitivity detecting trace metabolites limited specificity due interference other compounds, impacting reliability measurements. This review discusses field psychobiotics, compound estimation techniques, perspectives improvement quantifying

Язык: Английский

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Hesperetin-Enhanced Metformin to Alleviate Cognitive Impairment via Gut–Brain Axis in Type 2 Diabetes Rats

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1923 - 1923

Опубликована: Фев. 23, 2025

Diabetes constitutes a risk factor for cognitive impairment, whereas insulin resistance serves as the shared pathogenesis underlying both diabetes and decline. The use of metformin treating impairment remains controversial. present study found that hesperetin, flavanone derived from citrus peel, enhanced metformin's efficacy in reducing blood sugar levels, improving sensitivity, ameliorating diabetic rats. Additionally, it reduced required dosage to one-third its conventional dose. Transcriptome analysis 16S rRNA sequencing revealed activation cyclic-adenosine monophosphate response element binding protein (CREB)/brain-derived neurotrophic (BDNF) pathways benefited regulation gut microbiota promotion short-chain fatty acid (SCFA) producers such Romboutsia. Furthermore, this demonstrated hesperetin supplementation counteracted upregulation β-site amyloid precursor cleaving enzyme 1 (BACE1), pathological Alzheimer's disease (AD) was induced by metformin. Our findings reveal can be used supplementary treatment associated with diabetes.

Язык: Английский

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