Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials

EClinicalMedicine, Год журнала: 2024, Номер 70, С. 102519 - 102519

Опубликована: Март 11, 2024

Benefits of Intermittent fasting (IF) on health-related outcomes have been found in a range randomised controlled trials (RCTs). Our umbrella review aimed to systematically analyze and synthesize the available causal evidence IF its impact specific while evaluating quality.

Язык: Английский

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The Effect of Time-Restricted Eating Combined with Exercise on Body Composition and Metabolic Health: A Systematic Review and Meta-Analysis

Advances in Nutrition, Год журнала: 2024, Номер 15(8), С. 100262 - 100262

Опубликована: Июнь 17, 2024

Time-restricted eating (TRE) is increasingly popular, but its benefits in combination with exercise still need to be determined.

Язык: Английский

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Effects of time-restricted eating with exercise on body composition in adults: a systematic review and meta-analysis

International Journal of Obesity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Background The effects of time-restricted eating (TRE) with exercise on body composition in adults are not clear. Objective This meta-analysis aimed to assess the TRE when followed combination various forms exercise, including aerobic, resistance, and combined aerobic resistance [concurrent] training composition. Methods Studies published up May 2023 were searched EBSCOhost (MEDLINE, CINAHL, SPORTSDISCUS), PubMed, SCOPUS databases. Fifteen studies, 338 participants, that evaluated vs. unrestricted individuals performing analyzed. A random-effects model was used calculate weighted mean effect sizes (ES) 95% confidence intervals (95% CI’s). Results According pooled results, had a small but significant reduction fat mass (FM) kg an size −0.20 CI = −0.28 −0.13, p < 0.001) percent (BF%) −0.23 −0.35 −0.11, 0.001). prediction interval ranged from −0.48 0.08 for FM −0.64 0.18 BF%, respectively. did significantly alter fat-free (FFM) compared control ( 0.07). Furthermore, age, index (BMI), type, study duration, energy intake have impact variation according subgroup analyses > 0.05). Conclusion may reduce window exercise-matched while preserving FFM. However, more studies needed.

Язык: Английский

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Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 6, 2025

Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. This randomized clinical trial assessed the effects of combining time-restricted feeding (TRF; 16/8) Lacto-Ovo-Vegetarian (LOV) diet on various factors in overweight obese patients MAFLD. Forty-six participants were randomly assigned either intervention group (TRF LOV diet) or control group, 21 completing 12-week study each group. The showed significant reductions weight (-8.07 ± 4.31 kg), BMI (-2.70 1.32 kg/m2), waist circumference (-8.00 4.06 cm), as well ALT (-17.14 14.33 U/L), GGT (-21.09 24.06 Index (-26.90 15.81), levels (-3.89 4.69 mU/L), TNF-α (-11.85 12.52 pg/mL) compared (all P < 0.05). Lipid profiles also improved reduction triglycerides (-46.85 54.55 mg/dL) an increase HDL-C (3.91 5.07 (P These findings imply that TRF combined enhances metabolic markers, liver health, loss, thus potentially offering practical dietary approach for managing Further long-term studies are necessary validate these results investigate their applications.

Язык: Английский

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The Influence of Physical Exercise, Ketogenic Diet, and Time-Restricted Eating on De Novo Lipogenesis: A Narrative Review

Nutrients, Год журнала: 2025, Номер 17(4), С. 663 - 663

Опубликована: Фев. 13, 2025

De novo lipogenesis (DNL) is a metabolic pathway that converts carbohydrates into fatty acids, primarily occurring in the liver and, to lesser extent, adipose tissue. While hepatic DNL highly responsive dietary carbohydrate intake and regulated by insulin via transcription factors like SREBP-1c, more modest less sensitive overfeeding. Dysregulated contributes disorders, including dysfunction-associated steatotic disease (MASLD). Lifestyle interventions, such as physical exercise, ketogenic diets, time-restricted eating (TRE) offer promising strategies regulate improve health. Physical exercise enhances glucose uptake muscles, reduces levels, promotes lipid oxidation, thereby suppressing DNL. Endurance resistance training also mitochondrial function, further mitigating triglyceride accumulation. Ketogenic diets shift energy metabolism toward acid oxidation ketogenesis, lower insulin, directly downregulate lipogenic enzyme activity liver. TRE aligns feeding with circadian rhythms optimizing AMP-activated protein kinase (AMPK) activation during fasting periods, which suppresses metabolism. The combined effects of these interventions demonstrate significant potential for improving profiles, reducing triglycerides, preventing lipotoxicity. By addressing distinct roles DNL, target systemic localized dysregulation. Although research needed fully understand their long-term impact, findings highlight transformative integrating approaches clinical practice manage disorders associated complications.

Язык: Английский

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Healthy adipose tissue after menopause: contribution of balanced diet and physical exercise

Опубликована: Март 14, 2025

The accumulation of adipose tissue is associated with metabolic disorders, including insulin resistance, type 2 diabetes (T2D), dyslipidemia, syndrome, and cardiovascular diseases (CVD). Menopause might predispose women to increase body weight tissue, decrease lean muscle mass. Furthermore, postmenopausal display fat mass redistribution greater in the visceral area mainly due hormonal shifts that result a higher testosterone/estradiol ratio. These effects are less favorable adipokine profile, cardiac dysfunction after menopause. Fat determined by balance between storage triacylglycerol (TAG) (lipogenesis) removal stored TAG (lipolysis) combination differentiation new adipocytes (adipogenesis). Disturbances dynamics lead an lipogenesis (hypertrophy) and/or adipogenesis (hyperplasia) accommodate excess energy intake. While large dysfunctional have secretion inflammatory adipocytokines, small healthier improvements. Different strategies can be used prevent or reduce gain mass, as well maintain healthy tissue; however, robust evidence, lifestyle interventions should pillars this process. This review provides comprehensive summary findings on role balanced diet physical exercise improving composition promoting women.

Язык: Английский

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Time-Restricted Eating Versus Daily Calorie Restriction: Effects on Inflammatory Markers over 12 Months in Adults with Obesity

Nutrients, Год журнала: 2025, Номер 17(7), С. 1130 - 1130

Опубликована: Март 25, 2025

Background/Objectives: Obesity is associated with chronic systemic inflammation and elevated levels of inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP). Weight loss through lifestyle interventions can reduce in adults obesity. Time-restricted eating (TRE) calorie restriction (CR) are two popular diet that produce clinically significant weight loss. However, to date, no studies have directly compared the effects TRE versus CR on Methods: Here, we performed a secondary analysis recently published study compare long-term (12-month) key cytokines. Results: We found while produced similar amounts (4-5% from baseline), statistically changes circulating TNF-alpha, IL-6, CRP were noted or groups, controls, by month 12. did observe positively related body weight, visceral fat mass, insulin resistance, IL-6 TNF-alpha not any metabolic marker. Conclusions: Thus, may affect mediators 4-5% loss, but more research warranted.

Язык: Английский

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Eating Frequency, Timing, and Duration in Relation to Cognitive Performance and Alzheimer Disease Biomarkers in Adults

Journal of Nutrition, Год журнала: 2024, Номер 154(7), С. 2167 - 2175

Опубликована: Май 24, 2024

Язык: Английский

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Effect of Time-Restricted Eating on Circulating Levels of IGF1 and Its Binding Proteins in Obesity: An Exploratory Analysis of a Randomized Controlled Trial

Nutrients, Год журнала: 2024, Номер 16(20), С. 3476 - 3476

Опубликована: Окт. 14, 2024

Obesity is associated with alterations in circulating IGF1, IGF1-binding proteins (IGFBPs), insulin, inflammatory markers, and hormones implicated cardiovascular disease, diabetes, cancer, aging. However, the effects of 4 6 h time-restricted eating (TRE) on IGF1 IGFBPs uncertain. Objective: This study aimed to investigate TRE plasma IGFBP1, IGFBP2, IGFBP3, whether these were mediated by weight loss or body composition changes. Insulin sensitivity, glucose control, adipokines, markers also examined. Design: An exploratory analysis an 8-week randomized controlled trial implementing a daily intervention was carried out. Participants/Setting: conducted at University Illinois Chicago 2019. Participants obesity (n = 35) control 14) group. Plasma biomarkers measured ELISA baseline week 8. In sub-analysis, participants stratified into higher- (>3.5%) lower- (≤3.5%) weight-loss groups. Intervention: fasted from 7 p.m. 3 group (20 h) 1 (18 h), followed ad libitum for remainder day. Controls received no dietary recommendations. Main outcome measures: IGFBPs, hsCRP, adipokines main measures this analysis. Statistical Analysis: Repeated ANOVA mediation conducted. Results: Body significantly decreased (−3.6 ± 0.3%), contrasting controls (+0.2 0.5%, p < 0.001). Significant over time observed HOMA-IR, 8-isoprostane levels, without affecting other biomarkers. IGFBP2 increased while leptin only “higher loss” subgroup. Changes insulin HOMA-IR related adherence. Conclusions: Eight-week did not affect IGFBP3 levels but improved 8-isoprostane. when exceeded 3.5% baseline.

Язык: Английский

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Time-Restricted Eating and Bone Health: A Systematic Review with Meta-Analysis

Nutrients, Год журнала: 2024, Номер 16(6), С. 876 - 876

Опубликована: Март 18, 2024

Time-restricted eating (TRE) has emerged as a dietary strategy that restricts food consumption to specific time window and is commonly applied facilitate weight loss. The benefits of TRE on adipose tissue have been evidenced in human trials animal models; however, its impact bone remains unclear. To systematically synthesize examine the evidence health (bone mineral content (BMC), density (BMD), turnover factors), PubMed, Scopus, Cochrane CENTRAL, Web Science databases were explored from inception 1 October 2023 searching for randomized controlled (RCTs) aimed at determining effects adults (≥18 years). Handbook PRISMA recommendations followed. A total seven RCTs involving 313 participants (19 68 years) included, with an average length 10.5 weeks (range: 4 24 weeks). Despite significant loss reported five out studies when compared control, our meta-analysis showed no difference BMD (g/cm2) between groups (MD = -0.009, 95% CI: -0.026 0.009, p 0.328; I2 0%). BMC markers interventions control conditions not meta-analyzed because scarcity (less than five). short-term cardiometabolic health, did show detrimental outcomes those group. Nevertheless, caution should be taken interpreting results due adequately powered assess changes outcomes.

Язык: Английский

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