COVID‐19 disease and vaccination in pregnant and lactating women DOI Creative Commons
Marco Aurélio Palazzi Sáfadi, Júlia Spinardi, David L. Swerdlow

и другие.

American Journal of Reproductive Immunology, Год журнала: 2022, Номер 88(1)

Опубликована: Апрель 22, 2022

Abstract Background More than 325,000 cases of coronavirus disease 2019 (COVID‐19) have been reported among pregnant women in the Americas. Aims This review examines impact COVID‐19 and describes available evidence on safety, effectiveness, immune response(s) to vaccination lactating women. Content Multiple studies indicate that are more susceptible adverse outcomes, including hospitalization, intensive care unit admission, invasive ventilation non‐pregnant with COVID‐19. Furthermore, pregnancy is associated maternal neonatal outcomes. Adverse outcomes appear disproportionately affect from low‐ middle‐income countries, likely reflecting inequities access quality healthcare. Despite absence safety efficacy data randomized clinical trials this subpopulation, observational registries thus far demonstrated or against safe, effective, results robust responses transfer antibodies newborn via placenta breast milk, respectively. Implications These support recommendations intending help protect these vulnerable individuals its sequelae. Randomized will further evaluate immunogenicity vaccines populations.

Язык: Английский

SARS-CoV-2 placentitis, stillbirth, and maternal COVID-19 vaccination: clinical–pathologic correlations DOI Creative Commons
David A. Schwartz, Sarah B. Mulkey, Drucilla J. Roberts

и другие.

American Journal of Obstetrics and Gynecology, Год журнала: 2022, Номер 228(3), С. 261 - 269

Опубликована: Окт. 12, 2022

Stillbirth is a recognized complication of COVID-19 in pregnant women that has recently been demonstrated to be caused by SARS-CoV-2 infection the placenta. Multiple global studies have found placental pathology present cases stillbirth consists combination concurrent destructive findings include increased fibrin deposition typically reaches level massive perivillous deposition, chronic histiocytic intervillositis, and trophoblast necrosis. These 3 pathologic lesions, collectively termed placentitis, can cause severe diffuse parenchymal destruction affect >75% placenta, effectively rendering it incapable performing its function oxygenating fetus leading neonatal death via malperfusion insufficiency. Placental occur absence demonstrable fetal infection. Development placentitis complex process may both an infectious immunologic basis. An important observation all reported causing death, mothers were unvaccinated. likely result episode viremia at some time during pregnancy. This article discusses clinical aspects relationship between maternal vaccination, perinatal death.

Язык: Английский

Процитировано

79
Diabetes mellitus, maternal adiposity, and insulin-dependent gestational diabetes are associated with COVID-19 in pregnancy: the INTERCOVID study DOI Open Access
Brenda Eskenazi, Stephen Rauch, Enrico Iurlaro

и другие.

American Journal of Obstetrics and Gynecology, Год журнала: 2021, Номер 227(1), С. 74.e1 - 74.e16

Опубликована: Дек. 20, 2021

Язык: Английский

Процитировано

83
Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort Study DOI Open Access
Francesca Giuliani, D. Orós, Robert B. Gunier

и другие.

American Journal of Obstetrics and Gynecology, Год журнала: 2022, Номер 227(3), С. 488.e1 - 488.e17

Опубликована: Апрель 19, 2022

Язык: Английский

Процитировано

62
COVID-19 and Pregnancy DOI Open Access
Sonja A. Rasmussen, Denise J. Jamieson

Infectious Disease Clinics of North America, Год журнала: 2022, Номер 36(2), С. 423 - 433

Опубликована: Янв. 31, 2022

Язык: Английский

Процитировано

44
SARS-CoV-2 Vaccines during Pregnancy and Breastfeeding: A Systematic Review of Maternal and Neonatal Outcomes DOI Creative Commons
Domenico Umberto De Rose, Guglielmo Salvatori, Andrea Dotta

и другие.

Viruses, Год журнала: 2022, Номер 14(3), С. 539 - 539

Опубликована: Март 5, 2022

(1) Objective: This systematic review summarizes current knowledges about maternal and neonatal outcomes following COVID-19 vaccination during pregnancy breastfeeding. (2) Study design: PubMed, Cochrane Library, the Education Resources Information Center (ERIC) were searched up to 27 October 2021. The primary outcome was estimate how many pregnant lactating women reported be vaccinated had available outcomes. (3) Results: Forty-five studies sourcing data of 74,908 5098 who received considered as eligible. No major side-effects reported, especially second third trimester Conversely, revealed that infants specific SARS-CoV-2 antibodies after vaccination. (4) Conclusions: Vaccination against virus should recommended for women, pros cons have been adequately explained. In particular, given still limited evidence considering fever first months gestation increases possibility congenital anomalies, they carefully counseled. same considerations apply breastfeeding also immune responses mRNA vaccines can generate in their human milk.

Язык: Английский

Процитировано

44
Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry DOI Open Access
Mark L. Hudak, Dustin D. Flannery,

Kimberly Barnette

и другие.

PEDIATRICS, Год журнала: 2023, Номер 151(2)

Опубликована: Янв. 4, 2023

OBJECTIVES The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on effects perinatal severe acute respiratory syndrome 2 (SARS-CoV-2) infection. METHODS COVID-19 participating centers entered maternal newborn data pregnant persons who tested positive SARS-CoV-2 infection between 14 days before 10 after delivery. Incidence morbidities associated with were assessed. RESULTS From April 6, 2020 March 19, 2021, 242 in United States reported 7524 persons; at time delivery, 78.1% these asymptomatic, 18.2% symptomatic but not hospitalized specifically COVID-19, 3.4% treatment, 18 (0.2%) died hospital COVID-related complications. Among 7648 newborns, 6486 (84.8%) SARS-CoV-2, 144 (2.2%) positive; highest rate observed when mothers first immediate postpartum period (17 125, 13.6%). No deaths attributable Overall, 15.6% newborns preterm: among 30.1% polymerase chain reaction-positive 16.2% reaction-negative born preterm (P < .001). Need mechanical ventilation did differ by test result, those tests more likely be admitted a NICU. CONCLUSIONS Early pandemic, acquired variable rates without apparent short-term effects. During that preceded widespread availability vaccines, we higher than expected numbers births in-hospital deaths.

Язык: Английский

Процитировано

33
Influence of the COVID-19 pandemic and social media on the behaviour of pregnant and lactating women towards vaccination: a scoping review DOI Creative Commons
Larissa De Brabandere, Greet Hendrickx, Karolien Poels

и другие.

BMJ Open, Год журнала: 2023, Номер 13(2), С. e066367 - e066367

Опубликована: Фев. 1, 2023

Background Pregnant women, foetuses and infants are at risk of infectious disease-related complications. Maternal vaccination is a strategy developed to better protect pregnant women their offspring against morbidity mortality. Vaccines influenza, pertussis recently also COVID-19 widely recommended for women. Yet, there still significant amount hesitation towards maternal policies. Furthermore, contradictory messages circulating social media impact vaccine confidence. Objectives This scoping review aims reveal how impacted confidence in lactating Additionally, this studied the role plays creating opinions these target groups. Eligibility criteria Articles published between 23 November 2018 18 July 2022 that linked objectives were included. Reviews, articles not focusing on group, abstracts, describing outcomes infection/COVID-19 excluded. Sources evidence The PubMed database was searched select articles. Search terms used pregnancy, lactation, vaccination, hesitancy, media. Charting methods Included abstracted synthesised by one reviewer. Verification done second Disagreements addressed through discussion reviewers other researchers. Results generally less likely accept compared with non-pregnant non-nursing main reason refuse safety concerns. A positive link detected willingness acceptance vaccines during pregnancy. internet identified as important information sources vaccination. Discussion conclusion Vaccine hesitancy remains an issue, expressing need effective interventions increase coverage. uptake unclear.

Язык: Английский

Процитировано

24
Rapid assays of SARS-CoV-2 virus and noble biosensors by nanomaterials DOI Creative Commons
Yang Liu, Yilong Li,

Yuteng Hang

и другие.

Nano Convergence, Год журнала: 2024, Номер 11(1)

Опубликована: Янв. 8, 2024

Abstract The COVID-19 outbreak caused by SARS-CoV-2 in late 2019 has spread rapidly across the world to form a global epidemic of respiratory infectious diseases. Increased investigations on diagnostic tools are currently implemented assist rapid identification virus because mass and diagnosis might be best way prevent virus. This critical review discusses detection principles, fabrication techniques, applications with three categories: nuclear acid augmentation test, immunoassay test biosensors. Special efforts were put enhancement nanomaterials biosensors for rapid, sensitive, low-cost diagnostics Future developments suggested regarding potential candidates hospitals, clinics laboratories control prevention large-scale epidemic. Graphical

Язык: Английский

Процитировано

15
Maternal vaccination against COVID-19 and neonatal outcomes during Omicron: INTERCOVID-2022 study DOI Creative Commons
Fernando C. Barros, Robert B. Gunier,

Albertina Rego

и другие.

American Journal of Obstetrics and Gynecology, Год журнала: 2024, Номер 231(4), С. 460.e1 - 460.e17

Опубликована: Фев. 16, 2024

Язык: Английский

Процитировано

14
mRNA-1273 is placenta-permeable and immunogenic in the fetus DOI Creative Commons
Jeng‐Chang Chen, Mei‐Hua Hsu,

Rei-Lin Kuo

и другие.

Molecular Therapy — Nucleic Acids, Год журнала: 2025, Номер 36(1), С. 102489 - 102489

Опубликована: Фев. 17, 2025

COVID-19 mRNA vaccines are generally recognized as safe for gestational administration. However, their transplacental pharmacokinetics remain obscure. In this study, mRNA-1273 intramuscularly given to pregnant mice rapidly circulated in maternal blood and crossed the placenta within 1 h spread fetal circulation. Although spike circulation faded away 4-6 h, it could accumulate tissues, mainly liver get translated into protein. Transplacental proved immunogenic fetuses, postnatally equipped with anti-spike immunoglobulin (Ig)M, paternal allotypic IgG2a, heightened cellular immunity. Gestationally administered, had a dose-dependent effect on its transfer immunogenicity higher doses leading increased passage greater serum titers of endogenous IgM/IgG generated by fetuses. Thus, gestationally vaccination might endow newborns not only passive but also active Our results pose new insights capacity potential advancing our knowledge medicine protect unborns against pathogens perinatal life broaden horizons prenatal molecular therapy.

Язык: Английский

Процитировано

1