The intake of ultra-processed foods and homocysteine levels in women with(out) overweight and obesity: The Rotterdam Periconceptional Cohort

European Journal of Nutrition, Год журнала: 2024, Номер 63(4), С. 1257 - 1269

Опубликована: Фев. 21, 2024

Today's diet consists of a substantial proportion ultra-processed foods (UPF), especially in women with overweight and obesity the reproductive period. High UPF intake results an inadequate unbalanced leading to derangements several metabolic pathways detrimental pregnancy birth outcomes. Therefore, we aim investigate whether periconceptional period affects total homocysteine plasma levels (tHcy).

Язык: Английский

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The link between obesity and the gut microbiota and immune system in early-life

Critical Reviews in Microbiology, Год журнала: 2024, Номер unknown, С. 1 - 21

Опубликована: Апрель 23, 2024

In early-life, the gut microbiota is highly modifiable, being modulated by external factors such as maternal microbiota, mode of delivery, and feeding strategies. The composition child's will deeply impact development maturation its immune system, with consequences for future health. As one main sources microorganisms to child, mother represents a crucial factor in establishment early-life impacting infant's wellbeing. Recent studies have proposed that dysbiotic could be transmitted offspring, influencing immunity, leading diseases obesity. This paper aims review recent findings system interaction highlighting benefits balanced regulation system.

Язык: Английский

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Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women

Microbiology Spectrum, Год журнала: 2024, Номер 12(6)

Опубликована: Апрель 30, 2024

Our study aims to investigate the impact of probiotic consumption during pregnancy on gut microbiota functional diversity in healthy pregnant women. Thirty-two women were randomly assigned two groups. The group (PG) consisted who consumed triple viable

Язык: Английский

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Vitamin B12: prevention of human beings from lethal diseases and its food application

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер 105(1), С. 10 - 18

Опубликована: Июнь 24, 2024

Abstract Vitamin B12, a water‐soluble essential micronutrient, plays pivotal role in numerous physiological processes the human body. This review meticulously examines structural complexity and diverse mechanisms through which vitamin B12 exerts its preventive effects against spectrum of health conditions, including pernicious anaemia, neurological disorders, obesity, diabetes, dyslipidaemia complications foetal development. The selection articles for this was conducted systematic search across multiple scientific databases, PubMed, Scopus Web Science. Criteria inclusion encompassed relevance to biochemical impact on health, peer‐reviewed status publication within last decade. Exclusion criteria were non‐English studies lacking empirical evidence. stringent process ensured comprehensive analysis B12's multifaceted covering structure, bioavailable forms action. Clinical highlighting therapeutic potential, applications food fortification other utilizations are also discussed, underscoring nutrient's versatility. synthesis aims provide clear understanding integral maintaining potential clinical nutritional applications. © 2024 Author(s). Journal Science Food Agriculture published by John Wiley & Sons Ltd behalf Society Chemical Industry.

Язык: Английский

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Role of gut microbiota in thalassemia: a review of therapeutic prospects

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

In recent years, the study of gut microbiota has gradually become a research hotspot in field medicine, as dysbiosis is closely related to various diseases. Thalassemia, hereditary hemoglobinopathy, complex pathophysiological mechanism, and traditional treatment methods show limited efficacy. With deeper understanding microbiome, researchers have begun focus on its role pathogenesis thalassemia therapeutic effects. This article aims review potential prospects, analyze latest findings, explore impact mechanisms patients with thalassemia, goal providing new ideas directions for future clinical thalassemia.

Язык: Английский

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Protocol of the PROMOTE study: characterization of the microbiome, the immune response, and one-carbon metabolism in preconceptional and pregnant women with and without obesity (an observational subcohort of the Rotterdam Periconception cohort)

PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0319618 - e0319618

Опубликована: Апрель 2, 2025

Introduction Preconceptional and maternal obesity are well-known risk factors for pregnancy fetal complications including gestational diabetes, hypertensive disorders, macrosomia. Maternal is associated with offspring increased healthcare costs. To disrupt the cycle of obesity, we aim to investigate impact composition microbiota (bacteria viruses) throughout preconception associations immune responses one-carbon metabolism (1-CM) as an underlying mechanism in pathophysiology adverse outcomes obesity. Methods analysis The PROMOTE study a subcohort Rotterdam Periconceptional Cohort, hospital-based observational cohort study. We will include 70 women per BMI group: ≥ 30 kg/m 2 or 18.5-25 , at different time points each 10 preconceptional, 50 first trimester (with longitudinal follow-up during pregnancy, delivery postpartum) third pregnancy. Which makes total 140 inclusions. Vaginal rectal bacteriome, virome, blood samples collected. In inclusions, only faecal Microbiota be analysed using 16S rRNA sequencing. Bacteriome virome profiles compared between subgroups, general 1-CM markers shown. Trial registration ClinicalTrials.gov ( NCT05754645 )

Язык: Английский

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The Effect of Prebiotics and Probiotics (Synbiotics) on Weight Loss and Biochemical Parameters in Obese Individuals

Journal of Medicinal Food, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

This study examined the effects of prebiotic and probiotic (synbiotic) supplementation on weight loss biochemical parameters in treating obesity. The was conducted with 110 participants Eskisehir Anadolu Hospital, Turkiye, between February 15, 2019 2020. Individuals obesity, who were following a diet, randomly assigned to two groups. While one group (the control group) followed diet only, other received synbiotic tablets morning evening, addition diet. Anthropometric values patients measured at beginning 3 months after. A significant decrease found weight, body mass index (BMI), waist circumference compared baseline both groups (P: .001; P < .05). fasting blood sugar HOMA-IR Furthermore, there increase vitamin B12 D receiving synbiotics their values. As result our study, experienced similar BMI that took supplements increased significantly. significantly lower groups, albeit more group. Changes B12, D, are extremely important for improving health long term.

Язык: Английский

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Pregnancy-related changes in microbiome are disrupted by obesogenic diet exposure: implications for offspring microbiome development

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Maternal Caf diet altered offspring microbiota composition at weaning, with few differences in 14-week old offspring. Lower plasma folate diet-fed dams was associated lower abundance of OTU2_ Romboutsia and OTU3_ Lactobacillus weanlings.

Язык: Английский

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The Use of Prebiotics from Pregnancy and Its Complications: Health for Mother and Offspring—A Narrative Review

Foods, Год журнала: 2023, Номер 12(6), С. 1148 - 1148

Опубликована: Март 8, 2023

Pregnancy involves a metabolic reprogramming that includes changes in the gut microbiota composition women. Evidence shows maternal dysbiosis is linked to neonatal dysbiosis, and this factor can determine health status adulthood. Although there little literature available on topic, high heterogeneity limitation when examining nutritional interventions. Information has been gathered contrast benefits of prebiotic usage, specifically pregnancy, its possible complications newborns’ development. The objective pursued brief narrative review provide clear summary relevant content searching with regard use prebiotics effects prenatal postnatal periods, help clinical decision-making pregnancy management lactation. A search found pregnant mother key for earliest microbial colonization newborns, thus intervention programs from could assure better outcomes both offspring. In sense, (administered mothers who breastfeed or provided formula milk) are feasible cost-effective elements prevent allergies, colic, other maladies newborns.

Язык: Английский

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Bacteria from the gut influence the host micronutrient status

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(29), С. 10714 - 10729

Опубликована: Июнь 27, 2023

Micronutrient deficiencies or "hidden hunger" remains a serious public health problem in most low- and middle-income countries, with severe consequences for child development. Traditional methods of treatment prevention, such as supplementation fortification, have not always proven to be effective may undesirable side-effects (i.e., digestive troubles iron supplementation). Commensal bacteria the gut increase bioavailability specific micronutrients minerals), notably by removing anti-nutritional compounds, phytates polyphenols, synthesis vitamins. Together gastrointestinal mucosa, microbiota is also first line protection against pathogens. It contributes reinforcement integrity intestinal epithelium better absorption micronutrients. However, its role micronutrient malnutrition still poorly understood. Moreover, bacterial metabolism dependent acquired from environment resident compete collaborate maintain homeostasis. Gut composition can therefore modulated availability. This review brings together current knowledge on this two-way relationship between bacteria, focus iron, zinc, vitamin A folate (vitamin B9), these are concerns global context.

Язык: Английский

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