Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 453 - 482
Опубликована: Дек. 13, 2024
Gastrointestinal
tract
harbours
a
very
complex
and
dynamic
community
of
microorganisms
known
as
the
'gut
microbiota'.
These
microbes
are
involved
in
various
critical
physiological
processes,
including
digestion
biomolecules,
synthesis
vitamins,
modulation
immune
system,
protection
against
pathogens.
This
chapter
provides
comprehensive
overview
gut
brain
axis.
The
delves
into
role
microbial
metabolites
like
short
chain
fatty
acids,
tryptophan
bile
acids
neuronal
neurotransmitter
functioning.
Cytokine
release
system
activation
can
potentially
change
microbiota
composition.
psychological
stress
reducing
beneficial
bacteria
increasing
pathogenic
composition
has
been
detailed.
Psychological
lead
to
these
consequences
by
altering
permeability
intestinal
cells.
effect
compromised
on
health
through
altered
activity
discussed.
Biomolecules,
Год журнала:
2024,
Номер
14(8), С. 1017 - 1017
Опубликована: Авг. 16, 2024
Numerous
studies
have
evidenced
that
neuropsychiatric
disorders
(mental
illness
and
emotional
disturbances)
with
aggression
(or
violence)
pose
a
significant
challenge
to
public
health
contribute
substantial
economic
burden
worldwide.
Especially,
social
disorganization
inequality)
associated
childhood
adversity
has
long-lasting
effects
on
mental
health,
increasing
the
risk
of
developing
disorders.
Intestinal
bacteria,
functionally
as
an
endocrine
organ
second
brain,
release
various
immunomodulators
bioactive
compounds
directly
or
indirectly
regulating
host’s
physiological
behavioral
homeostasis.
Under
challenges,
stress-induced
dysbiosis
increases
gut
permeability
causes
serial
reactions:
releasing
neurotoxic
compounds,
leading
neuroinflammation
neuronal
injury,
eventually
aggressive,
violent,
impulsive
behavior
in
humans
animals
via
complex
bidirectional
communication
microbiota–gut–brain
(MGB)
axis.
The
dysregulation
MGB
axis
also
been
recognized
one
reasons
for
prevalence
injurious
behaviors
(feather
pecking,
aggression,
cannibalistic
pecking)
chickens.
However,
existing
knowledge
preventing
treating
these
both
chickens
is
not
well
understood.
In
previous
studies,
we
developed
non-mammal
model
abnormal
investigation
by
rationalizing
microbiota
Based
our
earlier
success,
perspective
article
outlines
possibility
reducing
through
modifying
cecal
transplantation,
potential
providing
biotherapeutic
rationale
among
individuals
restoring
diversity
function.
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 243 - 243
Опубликована: Фев. 7, 2025
The
microbiota-gut-brain
axis
is
a
complex
bidirectional
communication
system
that
involves
multiple
interactions
between
intestinal
functions
and
the
emotional
cognitive
centers
of
brain.
These
are
mediated
by
molecules
(metabolites)
produced
in
both
areas,
which
considered
mediators.
To
shed
light
on
this
mechanism,
still
largely
unknown,
reliable
characterization
mediators
essential.
Here,
we
review
most
studied
metabolites
axis,
metabolic
pathways
they
involved,
their
functions.
This
focuses
mainly
use
mass
spectrometry
for
determination,
reporting
latest
analytical
methods,
limitations,
future
perspectives.
strategy
qualitative-quantitative
must
be
order
to
elucidate
molecular
mechanisms
underlying
influence
above-mentioned
stress
resilience
or
vulnerability.
Immunosenescence,
the
slow
degradation
of
immune
function
over
time
that
is
a
hallmark
and
driver
aging,
makes
older
people
much
more
likely
to
be
killed
by
common
infections
(such
as
flu)
than
young
adults,
but
it
also
contributes
greatly
rates
chronic
inflammation
in
later
life.
Such
micro
nutrients
are
crucial
for
modulating
effective
responses
their
deficiencies
have
been
associated
with
dysfunctional
immunity
elderly.
In
this
review,
we
specifically
focused
on
contribution
major
(Vitamins
A,
D
E,
Vitamin
C;
Zinc
Selenium)
immunomodulators
ageing
population
especially
related
inflame-ageing
process
including
autoimmunity.
This
review
will
cover
these
hologenomic
interactions,
how
can
modulate
cell
and/or
cytokine
production
benefit
hosts
healthy
mucous-associated
along
sustainable
immunologic
homeostasis.
For
example,
points
out
modulatory
effects
vitamin
both
innate
adaptive
immunity,
specific
focus
its
ability
suppress
pro-inflammatory
cytokines
synthesis
while
enhancing
regulatory
T-cell
function.
same
context,
zinc
described
important
nutrient
thymic
differentiation
exhibits
immunomodulatory
functions
decreasing
inflammation.
addition,
go
increase
systemic
low-grade
and,
inflammaging
well
actually
enhance
autoimmune
pathologies
old
age.
It
assesses
potential
role
additional
targeted
nutritional
supplementation
counteract
effects,
promoting
wider
resilience
adults.
collates
current
evidence
highlights
adequate
intake
autoimmunity
during
ageing,
providing
plausible
origins
interventions
promote
aging.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 3, 2024
This
study
employed
Mendelian
randomization
(MR)
analysis
to
systematically
investigate
the
potential
connections
between
gut
microbiota
and
risk
of
glioblastoma
(GBM).
We
identified
12
microbial
groups
closely
associated
with
incidence
GBM.
Subsequently,
MR
was
conducted
on
1,091
blood
metabolites
309
metabolite
ratios,
revealing
19
that
exert
an
impact
occurrence
Hypothesizing
may
influence
multiforme
by
modulating
these
metabolites,
we
performed
analyses,
considering
each
group
as
exposure
outcome.
Through
constructed
a
regulatory
network
encompassing
microbiota,
GBM,
providing
novel
perspective
for
deeper
understanding
role
gut-brain
axis
in
pathogenesis
research
offers
crucial
insights
into
how
affect
GBM
regulating
specific
metabolites.
The
play
significant
formation
development
valuable
information
future
therapeutic
interventions.
Depression
and
anxiety
significantly
impact
the
quality
of
life
in
individuals
with
Cushing's
disease
(CD),
which
originates
from
pituitary
neuroendocrine
tumors
(PitNETs),
yet
our
understanding
underlying
mechanisms
is
limited.
There
substantial
evidence
linking
gut
microbes
to
depression,
anxiety,
endocrinology.
Health psychology research,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 4, 2024
In
the
latest
research,
concept
of
stress
is
associated
with
deregulation
several
biological
systems
sensitive
to
stress,
such
as
immune
system,
microbiome,
endocrine
system
and
neuroanatomical
substrates.
The
objective
research
was
identify
fecal
microbiome
in
patients
diagnosed
chronic
healthy
through
a
metabarcoding
analysis.
methodology
used
samples
collected
from
20
patients.
For
diagnosis
psychological
tools
previously
validated
by
external
researchers
were
used.
analysis,
metagenomic
DNA
extraction
performed
samples.
Next
Generation
Illumina
genetic
sequencing
targeting
16S
rDNA
gene
then
performed,
followed
bioinformatic
analysis
using
QUIME
II
software.
results,
at
test
level,
people
diagnosed,
on
other
hand,
specifically
Gender
Asteroleplasma
bacteria
present
only
molecularly
identified.
On
Alistipes
Bifidobacterium
identified
greater
predominance
stress.
Concluding,
are
candidates
possible
markers
intestinal
bacterial
marker
people.
Finally,
identification
opens
new
path
understanding
its
relationship
dysregulation
microbiome.
