Intraoperative Esketamine and Postpartum Depression Among Women With Cesarean Delivery

JAMA Network Open, Год журнала: 2025, Номер 8(2), С. e2459331 - e2459331

Опубликована: Фев. 13, 2025

Importance Esketamine has been found to reduce the incidence of postpartum depression (PPD) in randomized clinical trials. However, current evidence from trials does not reflect esketamine’s efficacy settings. Objective To assess intraoperative esketamine administration for preventing PPD among women who underwent cesarean delivery. Design, Setting, and Participants This trial was conducted at The First Affiliated Hospital Chongqing Medical University Chongqing, China, March 2023 February 2024. Pregnant patients admitted delivery were included, while those with intellectual dysfunction or contraindications excluded. All participants assigned randomly either group control a 1:1 ratio. Data analysis based on intention-to-treat principle. Interventions Patients received an infusion 0.25 mg/kg 20 mL saline over minutes, whereas minutes. Main Outcomes Measures primary outcome 6 weeks post partum. assessed using Edinburgh Postnatal Depression Scale. Results A total 308 pregnant 1 2 groups: (n = 154; mean [SD] patient age, 31.57 [4.26] years) 32.53 [7.74] years). Incidence significantly lower compared partum (10.4% [16] vs 19.5% [30]; relative risk, 0.53; 95% CI, 0.30-0.93; P .02). Conclusions Relevance demonstrated advantage reducing safety warrant further investigation practice. Trial Registration Chinese Clinical Registry Identifier: ChiCTR2200065494

Язык: Английский

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Esketamine reduces the risk of postpartum depression in women undergoing cesarean section: a systematic review and meta-analysis

Journal of Psychiatric Research, Год журнала: 2025, Номер 183, С. 164 - 173

Опубликована: Фев. 14, 2025

Язык: Английский

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Postpartum depression: The silent dilemma of Chinese newborn mothers and coping strategies

Asian Journal of Psychiatry, Год журнала: 2025, Номер unknown, С. 104429 - 104429

Опубликована: Март 1, 2025

Язык: Английский

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Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 12, 2025

Postpartum depression (PPD) significantly impacts women's mental health and social functioning, yet effective therapies remain limited. This study investigates the preventive effects of music therapy on PPD-like behaviors underlying neurobiological mechanisms in a mouse model subjected to ovarian hormone withdrawal (HW). Mice exposed daily sessions exhibited markedly reduced depression- anxiety-like behaviors, as evidenced by enhanced performance behavioral tests such open field test (OFT), forced swim (FST), elevated plus maze (EPM), sucrose preference (SPT), novelty-suppressed feeding (NSF) test, tail suspension (TST). Furthermore, normalized oxidative stress indicators (NO, MDA, SOD, CAT, GSH-Px, T-AOC, ATP, glutamate) serum, hippocampus, prefrontal cortex. Additionally, exposure levels proinflammatory factors (IL-6, IL-1β, iNOS, TNF-α, TGF-β) activation microglia astrocytes these brain regions. Notably, preserved neuronal integrity, promoted neurogenesis, maintained synaptic plasticity, restoration dendritic spines. Transcriptome sequencing identified differential gene expression pathways related inflammation, stress. These findings suggest that prevents PPD modulating stress, providing robust preclinical evidence for its potential natural intervention PPD. underscores need further clinical research validate therapeutic efficacy preventing humans, highlighting promise non-invasive accessible treatment modality.

Язык: Английский

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Postpartum Depression and Child Mental Health Outcomes: Evidenced-Based Interventions

Current Treatment Options in Psychiatry, Год журнала: 2025, Номер 12(1)

Опубликована: Апрель 15, 2025

Язык: Английский

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Does Esketamine Peripartum Intervention Reduce the Risk of Postpartum Depression? A Systematic Review and Meta-Analysis of Obstetric Anesthesia and Analgesic Approaches

Опубликована: Янв. 1, 2025

Язык: Английский

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Merits and demerits of administering esketamine in preventing postpartum depression following cesarean section

World Journal of Clinical Cases, Год журнала: 2024, Номер 12(36), С. 6883 - 6886

Опубликована: Окт. 30, 2024

Emergency cesarean section is associated with the development of postpartum depression. Esketamine has been demonstrated to have a rapid onset antidepressant effects. Randomized controlled trials and meta-analyses efficacy esketamine in preventing depression after cessarean section. However, data included these analyses were derived from elective sections differed dose timing administration. dissociative anesthetic dose-dependent risk inducing psychotic symptoms, including hallucinations. In setting section, should be administered caution only if potential benefits outweigh risks.

Язык: Английский

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Perioperative administration of esketamine during cesarean section is a double-edged sword

Psychiatry Research, Год журнала: 2024, Номер 344, С. 116321 - 116321

Опубликована: Дек. 9, 2024

Язык: Английский

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