Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model

Biomedicines, Год журнала: 2025, Номер 13(3), С. 541 - 541

Опубликована: Фев. 21, 2025

Background/Objectives: Dry eye (DE) is mainly characterized by dryness, foreign body sensation, pain and visual impairment. Their possible causes are inflammation, tissue damage neurosensory abnormalities, vitamin B6 (VitB6) attenuates the inflammatory response modulating NF-κB pathway to quench reactive oxygen species (ROS). The aim of this experiment was investigate therapeutic effect VitB6 drops on particulate matter 2.5 (PM2.5)-induced dry in mice. Methods: Mice induced with group were first using PM2.5 a standard environment for 14 days, then treated different concentrations consecutive days. phenol red cotton test used measure tear production. Ocular inflammation index film function evaluated slim microscopy. Hematoxylin–eosin (HE) staining observe conjunctival corneal structure. Periodate–Schiff (PAS) quantify goblet cells. Corneal cell apoptosis determined TUNEL assay. expression keratin 10 (K10) p-NF-κB p65 detected immunofluorescent Western blot analysis. Results: only model all exhibited varying degrees symptoms. treatment increased secretion reduced indices mice nerve density number branches basement membrane epithelium. Conclusions: We found that administering has PM2.5-induced DE. This observation suggests may be useful clinical therapy

Язык: Английский

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Modular network analysis of abnormal functional connectivity and disrupted brain topology caused by sleep deprivation and its association with cognitive function

Sleep Medicine, Год журнала: 2025, Номер unknown, С. 106514 - 106514

Опубликована: Апрель 1, 2025

Язык: Английский

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Exploring the association between sleep duration and cancer risk in middle-aged and older Chinese adults: observations from a representative cohort study (2011–2020)

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 8, 2024

Abstract Background This prospective cohort study aimed to investigate the relationship between sleep duration and cancer incidence among 9996 participants over a median follow-up period of 9 years. Methods Participants without at baseline were followed for 88,790 person-years. The was self-reported. analyzed using Cox proportional hazards models adjusted various confounding factors, including age, gender, lifestyle comorbidities. Results During follow-up, 325 diagnosed with incident cancer, resulting in an rate 20.49 per 1000 After adjusting confounders, total less than 6 h significantly associated increased risk (HR: 1.27; 95% CI: 1.01–1.61). association particularly strong cancers digestive respiratory systems 1.41; 1.03–1.93). Longer durations (> h) showed potential increase risk, but results not consistently significant. Age-stratified analyses revealed similar significant individuals aged 60 years or younger day, showing 35% overall 83% system cancer. No found nocturnal daytime naps incidence. However, interaction observed longer 30 min women ( p = 0.041). Conclusions We that short may systems. Additionally, while might also this finding requires validation larger sample sizes.

Язык: Английский

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Chronic sleep deprivation induces erectile dysfunction through increased oxidative stress, apoptosis, endothelial dysfunction, and corporal fibrosis in a rat model

The Journal of Sexual Medicine, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Язык: Английский

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