Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice DOI Creative Commons
Senmao Li, Jingyi Xie,

Jiayan Xiang

и другие.

Investigative Ophthalmology & Visual Science, Год журнала: 2025, Номер 66(4), С. 40 - 40

Опубликована: Апрель 16, 2025

To investigate the impact of corneal sensory nerve injury on lacrimal gland function, focusing mechanisms involving superior salivatory nucleus (SSN), circadian rhythm disruption, immune microenvironment alterations, and potential for neural regeneration. A murine model was used to assess with tear secretion measured using phenol red thread test. Transcriptomic analysis glands examined immune-related gene expression. Basic fibroblast growth factor (bFGF) promote regeneration, its effects repair were evaluated. Corneal resulted in a 35% reduction significantly impaired SSN activity, as evidenced by 31% decrease c-FOS-positive neurons choline acetyltransferase (ChAT)-expressing neurons. revealed significant downregulation pathways, including Toll-like receptor (TLR), NOD-like (NLR), T-cell signaling. Circadian expression exhibited phase shifts, 2.13-hour delay peak substantial change number types rhythmic genes, which enriched different signaling pathways. The bFGF treatment restored 22% promoted although fiber density remained 74% lower than that controls. disrupts both central peripheral clock functions gland, leading reduced dysregulation. These findings highlight novel role rhythms neural-immune interactions dysfunction. Neural regeneration strategies, such bFGF, offer therapeutic dry eye syndrome, providing new directions clinical intervention.

Язык: Английский

Short-Chain Fatty Acids and the Gut–Retina Connection: A Systematic Review DOI Open Access
Elena Ciurariu,

Andreea-Talida Tîrziu,

Norberth-Istvan Varga

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2470 - 2470

Опубликована: Март 10, 2025

The interplay between gut microbiota and retinal health, known as the gut-–retina axis, has gained increasing attention in recent years. Short-chain fatty acids (SCFAs), metabolites produced by microbiota, have been identified key mediators of gut–retina communication. This systematic review explores role SCFAs health their potential impact on development progression diseases, such diabetic retinopathy (DR), age-related macular degeneration (AMD), glaucoma. A literature search was conducted across multiple databases, including PubMed, Google Scholar, Science Direct, to identify studies published 2014 December 2024. Studies were included if they investigated effects structure, function, or disease pathogenesis animal models human subjects. 10 original articles spanning both preclinical clinical studies. Evidence suggests that play a crucial maintaining homeostasis through anti-inflammatory neuroprotective mechanisms. Dysbiosis leading altered SCFA production, associated with increased inflammation, oxidative stress, vascular dysfunction. Furthermore, reduced levels linked degeneration. Modulation dietary interventions probiotics may represent novel therapeutic strategy for preventing managing diseases. Further research is needed elucidate precise molecular mechanisms underlying SCFA-mediated protection evaluate efficacy targeted therapies settings.

Язык: Английский

Процитировано

0
Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice DOI Creative Commons
Senmao Li, Jingyi Xie,

Jiayan Xiang

и другие.

Investigative Ophthalmology & Visual Science, Год журнала: 2025, Номер 66(4), С. 40 - 40

Опубликована: Апрель 16, 2025

To investigate the impact of corneal sensory nerve injury on lacrimal gland function, focusing mechanisms involving superior salivatory nucleus (SSN), circadian rhythm disruption, immune microenvironment alterations, and potential for neural regeneration. A murine model was used to assess with tear secretion measured using phenol red thread test. Transcriptomic analysis glands examined immune-related gene expression. Basic fibroblast growth factor (bFGF) promote regeneration, its effects repair were evaluated. Corneal resulted in a 35% reduction significantly impaired SSN activity, as evidenced by 31% decrease c-FOS-positive neurons choline acetyltransferase (ChAT)-expressing neurons. revealed significant downregulation pathways, including Toll-like receptor (TLR), NOD-like (NLR), T-cell signaling. Circadian expression exhibited phase shifts, 2.13-hour delay peak substantial change number types rhythmic genes, which enriched different signaling pathways. The bFGF treatment restored 22% promoted although fiber density remained 74% lower than that controls. disrupts both central peripheral clock functions gland, leading reduced dysregulation. These findings highlight novel role rhythms neural-immune interactions dysfunction. Neural regeneration strategies, such bFGF, offer therapeutic dry eye syndrome, providing new directions clinical intervention.

Язык: Английский

Процитировано

0