Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106912 - 106912
Опубликована: Апрель 1, 2025
Язык: Английский
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 15
Опубликована: Янв. 28, 2025
Gout is a commonly occurring form of inflammatory arthritis caused by persistently elevated levels uric acid. Its incidence rate rises with the increases living standards and poor dietary habits, which has considerable impact on quality life patients. Although there wide assortment drugs available for management gout, effectiveness security these are limited their chemical stability insufficient targeting. Therefore, development effective nanomedicine systems to overcome problems treat gout becomes high priority. This review provides detailed introduction research progress developing advanced nanomedicines using polymers, hydrogel, nanocapsules, lipids, bionic vesicles, inorganic artificial organelles electronically controlled conveyor carriers improve therapy.
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер 106, С. 106696 - 106696
Опубликована: Фев. 6, 2025
Язык: Английский
Процитировано
1
Frontiers of Medicine, Год журнала: 2024, Номер 18(2), С. 258 - 284
Опубликована: Янв. 13, 2024
Язык: Английский
Процитировано
6
Inflammation Research, Год журнала: 2024, Номер 73(4), С. 541 - 562
Опубликована: Фев. 12, 2024
Язык: Английский
Процитировано
6
Engineered Regeneration, Год журнала: 2023, Номер 5(1), С. 92 - 110
Опубликована: Дек. 14, 2023
Osteoarthritis (OA) represents an enduring and widespread global burden, causing significant morbidity disability, whose pathology is characterized by persistent inflammation, progressive cartilage degeneration, abnormal bone homeostasis, excessive synovial hyperplasia, resulting from its complex microenvironment. Unfortunately, current therapeutic approaches for OA remain suboptimal, prompting increased interest in advanced nanotechnology as a means to enhance effects. In recent years, progress has been made the development of versatile nanoplatforms designed specific microenvironment OA, promising results introducing concept "OA nanomedicine". Compared conventional therapies like non-steroidal anti-inflammatory drugs (NSAIDs), nanomedicine offers precise targeted, controllable personalized ways therapy, contributing better outcomes. However, comprehensive review consolidating nanomedicine" currently absent literature. Therefore, this review, we aim unravel key pathological microenvironmental characteristics while summarizing properties advantages nanosystems possessing microenvironment-reprogramming capabilities therapy. First, make retrospection features Furthermore, provide overview advances nanomedicine. Eventually, discuss present challenges associated with insights into future prospects clinical-translational lens. By doing so, can foster propel successful nanomedicine, addressing unmet needs
Язык: Английский
Процитировано
15
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115135 - 115135
Опубликована: Июль 13, 2023
Exosomes, remarkable extracellular vesicles, have emerged as an advanced frontier in intercellular communication. This capacity positions them promising contenders drug delivery systems (DDSs) for osteoarthritis (OA) therapy, capitalizing on their inherent biocompatibility, stability, and minimal immunogenicity. In this comprehensive review, we summarize the emerging developments surrounding exosome-based DDSs OA therapy. Focusing exosome origins, meticulously explore diverse sources contributing to production, including invaluable stem cells, immune array of other cell types. addition, unravel underlying mechanisms action that govern these exosome-borne therapeutics, illuminating intricate interplay between exosomes recipient cells. summary, review highlights present challenges permeate Through in-depth exploration intricacies within field, aims shed light future direction OA. It serves a bridge fostering collaboration collective efforts reshaping treatment landscape
Язык: Английский
Процитировано
14
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 5, 2024
Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due its hepatotropism, the virus (HBV) cannot infect other cells. The mechanisms underlying intercellular communication among different liver cells in HBV-infected individuals microenvironment imbalance remain elusive. Exosomes, as important cargo transportation tools between hepatocytes have been shown assist HBV regulate microenvironment. However, role of exosomes has only gradually received attention recent years. Minimal literature systematically elaborated on reshaping liver. This review unfolds sequentially based biological processes exosomes: exosomes' biogenesis, release, transport, uptake by recipient their impact We delineate how influences biogenesis exosomes, utilizing exosomal covert transmission, reshapes hepatic And characteristics functions potential applications are summarized predicted.
Язык: Английский
Процитировано
5
Biochemical Pharmacology, Год журнала: 2024, Номер 223, С. 116138 - 116138
Опубликована: Март 15, 2024
Central nervous system lymphoma (CNSL) is a type of hematological tumor. Treatment CNSL difficult due to the existence blood-brain barrier (BBB). Here, we used exosomes (Exos), extracellular vesicle, and iRGD construct new drug carrier use it load doxorubicin (DOX). The results in vitro vivo experiments showed that iRGD-Exo-DOX can efficiently securely transport DOX through BBB target tumor cells. suggest may cross brain microvascular endothelial cell-mediated endocytosis. Together, our study indicates an impactful treatment central tumors.
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132909 - 132909
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
4
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0