Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(2), С. 100905 - 100905

Опубликована: Март 16, 2024

Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) CaCO3 CaCO3-assisted emulsion method, aiming at effective of TNBC. We found that obtained nanomedicine (DHCaNPs) exhibited drug encapsulation pH-responsive release behavior. Moreover, DHCaNPs demonstrated robust capabilities neutralizing protons oxygen transport. Consequently, could serve nanoshuttles to attenuate hypoxia neutralize microenvironment (TME) depleting lactic acid, thereby effectively overcoming resistance chemotherapy. Furthermore, notable ability enhance antitumor immune responses increasing frequency tumor-infiltrating effector lymphocytes reducing various immune-suppressive cells, therefore exhibiting superior suppressing growth metastasis when combined anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights TME, offering promising strategy figure out an enhanced chemo-immunotherapy benefit TNBC patients.

Язык: Английский

---

Dendrimer multifunctional complexes for genetic therapy of cancer

Science and Innovations, Год журнала: 2025, Номер 1(1), С. 78 - 83

Опубликована: Фев. 18, 2025

Every year there is a rapid increase in cancer, which one of the main causes death. Methods used to treat cancer often do not produce desired results and can cause various side effects. Therefore, effectively combat it necessary find new solutions. The use nanotechnology opens up opportunities diagnosis treatment human malignant tumors. Nanoparticles antitumor therapy act as carriers drugs nucleic acids, also reduce toxicity anticancer drugs. This review devoted analysis interaction nanomaterials with small RNAs. Data are presented on some non-toxic effective multifunctional nanoconjugates gene for cancer.

Язык: Английский

---

An Investigation of the Effect of the Traditional Naxi Herbal Formula Against Liver Cancer through Network Pharmacology, Molecular Docking and In Vitro Experiments

Опубликована: Авг. 20, 2024

The formula Chong-Lou-Yao-Fang (CLYF) is an herbal medicinal formulation developed by the indigenous Naxi people for treating liver cancer. This study to reveal biological activity, potential targets, and molecular mechanisms of CLYF cancer treatment through network pharmacology, docking in vitro experiments. 35 key compounds were screened from 176 active ingredients CLYF, which played a vital role cancer, 20 core targets filtered protein–protein interaction (PPI) analysis. enrichment analysis Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) indicated that PI3K-Akt, MAPK, hepatitis B, C might be effective treatment. Mo-lecular revealed stable binding between EGFR, TP53, AKT1 with ingredients. Experiments cell cultures confirmed CLYF-A suppressed proliferation HepG2 cells, consistent pharmacology approach undertaken predictions docking. also induced significant apoptosis cycle arrest was associated loss mitochondrial membrane potential. explored Our results may provide scientific basis clinical use have important implications developing pharmaceutical preparations, need more phar-macological

Язык: Английский

---

Enhancing Chemoimmunotherapy for Colorectal Cancer with Paclitaxel and Alantolactone via CD44-Targeted Nanoparticles: A STAT3 Signaling Pathway Modulation Approach

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 20(1), С. 100993 - 100993

Опубликована: Ноя. 12, 2024

Chemoimmunotherapy has the potential to enhance chemotherapy and modulate immunosuppressive tumor microenvironment by activating immunogenic cell death (ICD), making it a promising strategy for clinical application. Alantolactone (A) was found augment anticancer efficacy of paclitaxel (P) at molar ratio 1:0.5 (P:A) through induction more potent ICD via modulation STAT3 signaling pathways. Nano drug delivery systems can synergistically combine natural drugs with conventional chemotherapeutic agents, thereby enhancing multi-drug chemoimmunotherapy. To improve targeting ability bioavailability hydrophobic drugs, an amphiphilic prodrug conjugate (HA-PTX) chemically modified (PTX) hyaluronic acid (HA) as backbone. Based on this concept, CD44-targeted nanodrugs (A@HAP NPs) were developed co-delivery A P in colorectal cancer treatment, aiming achieve synergistic toxicity-based chemo-immunotherapy. The uniform size high loading capacity A@HAP NPs facilitated their accumulation within tumors enhanced permeability retention effect well HA-mediated targeting, providing solid foundation subsequent therapy immunoregulation. In vitro vivo studies demonstrated that exhibited cytotoxicity against cells while also remodeling immune-suppressive promoting antigen presentation inducing dendritic maturation, thus offering novel approach

Язык: Английский

---

An Investigation of the Effect of the Traditional Naxi Herbal Formula Against Liver Cancer Through Network Pharmacology, Molecular Docking, and In Vitro Experiments

Pharmaceuticals, Год журнала: 2024, Номер 17(11), С. 1429 - 1429

Опубликована: Окт. 25, 2024

: The formula Chong-Lou-Yao-Fang (CLYF) is an herbal medicinal formulation developed by the indigenous Naxi people for treating liver cancer. This study was to reveal biological activity, potential targets, and molecular mechanisms of CLYF cancer treatment.

Язык: Английский

---