Radioresistance-related gene signatures identified by transcriptomics characterize the prognosis and immune landscape of pancreatic cancer patients DOI Creative Commons

Dandan Wang,

Jun Cao,

Yanhui Chen

и другие.

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 5, 2024

Radiotherapy (RT) is an important means of local treatment solid tumors, and radioresistance the main reason for RT failure especially pancreatic cancer (PC). It urgent to distinguish key genes mechanisms in PC. We acquired data from The Cancer Genome Atlas (TCGA), obtained gene modules associated with by weighted coexpression network analysis (WGCNA), identified differentially expressed (DEGs) between normal tumor samples. Radioresistance-related (RRRGs) were determined intersection WGCNA DEGs. hub RRRGs prognosis distinguished least absolute shrinkage selection operator (LASSO) regression. established a risk score model using multivariate Cox Immune cell infiltration drug sensitivity evaluated through CIBERSORT algorithm "OncoPredict" software package, respectively. association RIC3 PC clinical features was verified public databases, its biological behaviors explored vitro. DEGs confirmed 14 RRRGs, then six LASSO. A four (DUSP4, ADORA2B, SCGB2A1, RIC3) constructed proved be capable independently estimating There no significant difference groups various immune response immunotherapy. Although low-risk group seemed exhibit greater antitumor drugs, drugs (5-fluorouracil [5-FU], leucovorin, irinotecan, oxaliplatin) currently used patients had statistical low- high- group. overexpression synergy effect irradiation on inhibited malignant properties cells, which detecting proliferation ability, apoptosis rate, cycle distribution, migration ability PANC-1 cells. herein presented signature correlated competent patients' outcomes drugs. above evidence could contribute comprehending identifying underlying therapy targeting.

Язык: Английский

Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer DOI Creative Commons
Jiayi Zhang, Mengqin Yao, Siyu Xia

и другие.

Cellular & Molecular Biology Letters, Год журнала: 2025, Номер 30(1)

Опубликована: Янв. 6, 2025

Abstract Hypoxia-inducible factors (HIFs) are essential transcription that orchestrate cellular responses to oxygen deprivation. HIF-1α, as an unstable subunit of HIF-1, is usually hydroxylated by prolyl hydroxylase domain enzymes under normoxic conditions, leading ubiquitination and proteasomal degradation, thereby keeping low levels. Instead hypoxia, sometimes even in normoxia, HIF-1α translocates into the nucleus, dimerizes with HIF-1β generate then activates genes involved adaptive such angiogenesis, metabolic reprogramming, survival, which presents new challenges insights its role processes. Thus, review delves mechanisms HIF-1 maintains stability normoxia including but not limited giving transcriptional, translational, well posttranslational regulation underscore pivotal adaptation malignancy. Moreover, extensively cancer cardiovascular diseases potentially serves a bridge between them. An overview HIF-1-related drugs approved or clinical trials summarized, highlighting their potential capacity for targeting toxicity related treatment. The provides comprehensive insight HIF-1’s regulatory mechanism paves way future research therapeutic development.

Язык: Английский

Процитировано

3
STAT1 increases the sensitivity of lung adenocarcinoma to carbon ion irradiation via HO-1-mediated ferroptosis DOI
Yanliang Chen, Dandan Wang, Hongtao Luo

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

0
Human Serum Albumin‐Coated 10B Enriched Carbon Dots as Targeted “Pilot Light” for Boron Neutron Capture Therapy DOI Creative Commons

Tianyuan Zhong,

Yongjin Yang,

Miao Pang

и другие.

Advanced Science, Год журнала: 2024, Номер 11(43)

Опубликована: Сен. 26, 2024

Abstract Boron neutron capture therapy (BNCT) is a physiologically focused radiation that relies on nuclear and fission processes. BNCT regarded as one of the most promising treatments due to its excellent accuracy, short duration therapy, low side effects. The creation novel boron medicines with high selectivity, ease delivery, boron‐effective load current research topic. Herein, boron‐containing carbon dots (BCDs) their human serum albumin (HSA) complexes (BCDs‐HSA) are designed synthesized drugs for BNCT. BCDs ( 10 B: 7.1 wt%) BCDs‐HSA exhibited excitation‐independent orange fluorescent emission which supported use fluorescence imaging tracking B in vivo. introduction HSA enabled exhibit good biocompatibility increased tumor accumulation. active passive targeting abilities explored detail. Subcutaneous RM‐1 tumors B16‐F10 both significantly decrease BNCT, consists injecting then irradiating area neutrons. In short, this study provides strategy delivery may broaden perspectives design nanomedicine

Язык: Английский

Процитировано

2
Engineered exosomes in service of tumor immunotherapy: From optimizing tumor‐derived exosomes to delivering CRISPR/Cas9 system DOI
Mingyang Jiang, Ke Zhang,

Jinfeng Meng

и другие.

International Journal of Cancer, Год журнала: 2024, Номер 156(5), С. 898 - 913

Опубликована: Окт. 30, 2024

Exosomes can be modified and designed for various therapeutic goals because of their unique physical chemical characteristics. Researchers have identified tumor-derived exosomes (TEXs) as significant players in cancer by influencing tumor growth, immune response evasion, angiogeneis, drug resistance. TEXs promote the production specific proteins important progression. Due to easy accessibility, are being through genetic, delivery, membrane, system, alterations repurposed vehicles delivering drugs improve treatment outcomes. In complex vivo environment, clustered regularly interspaced short palindromic repeats CRISPR-associated protein 9 (CRISPR/Cas9) system encounters challenges from degradation, neutralization, responses, emphasizing need strategic distribution strategies effective genome editing. Engineered present a promising avenue CRISPR/Cas9 vivo. this review, we will explore different techniques enhancing using engineering strategies. Additionally, discuss how these incorporated into advanced genetic systems like possible uses.

Язык: Английский

Процитировано

1
Recent advances in spatio-temporally controllable systems for management of glioma DOI Creative Commons
Huiwen Zhang,

Wanqi Zhu,

Wei Pan

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(5), С. 100954 - 100954

Опубликована: Авг. 23, 2024

Malignant glioma remains one of the most aggressive intracranial tumors with devastating clinical outcomes despite great advances in conventional treatment approaches, including surgery and chemotherapy. Spatio-temporally controllable approaches to are now being actively investigated due preponderance, spatio-temporal adjustability, minimally invasive, repetitive properties, etc. External stimuli can be readily controlled by adjusting site density exert cytotoxic on tissue avoid undesired injury normal tissues. It is worth noting that removability external allows for on-demand treatment, which effectively reduces occurrence side effects. In this review, we highlight recent advancements drug delivery systems spatio-temporally treatments glioma, focusing mechanisms design principles sensitizers utilized these therapies. Moreover, potential challenges regarding therapy also described, aiming provide insights into future field their applications.

Язык: Английский

Процитировано

0
Radioresistance-related gene signatures identified by transcriptomics characterize the prognosis and immune landscape of pancreatic cancer patients DOI Creative Commons

Dandan Wang,

Jun Cao,

Yanhui Chen

и другие.

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 5, 2024

Radiotherapy (RT) is an important means of local treatment solid tumors, and radioresistance the main reason for RT failure especially pancreatic cancer (PC). It urgent to distinguish key genes mechanisms in PC. We acquired data from The Cancer Genome Atlas (TCGA), obtained gene modules associated with by weighted coexpression network analysis (WGCNA), identified differentially expressed (DEGs) between normal tumor samples. Radioresistance-related (RRRGs) were determined intersection WGCNA DEGs. hub RRRGs prognosis distinguished least absolute shrinkage selection operator (LASSO) regression. established a risk score model using multivariate Cox Immune cell infiltration drug sensitivity evaluated through CIBERSORT algorithm "OncoPredict" software package, respectively. association RIC3 PC clinical features was verified public databases, its biological behaviors explored vitro. DEGs confirmed 14 RRRGs, then six LASSO. A four (DUSP4, ADORA2B, SCGB2A1, RIC3) constructed proved be capable independently estimating There no significant difference groups various immune response immunotherapy. Although low-risk group seemed exhibit greater antitumor drugs, drugs (5-fluorouracil [5-FU], leucovorin, irinotecan, oxaliplatin) currently used patients had statistical low- high- group. overexpression synergy effect irradiation on inhibited malignant properties cells, which detecting proliferation ability, apoptosis rate, cycle distribution, migration ability PANC-1 cells. herein presented signature correlated competent patients' outcomes drugs. above evidence could contribute comprehending identifying underlying therapy targeting.

Язык: Английский

Процитировано

0