Kinases and Phosphatases, Год журнала: 2025, Номер 3(2), С. 9 - 9
Опубликована: Апрель 21, 2025
Kinase inhibitors are small molecules that block kinase activity and have significant applications in both therapy diagnostics. Recent studies suggest these hold great potential as targets for treating a range of diseases, including autoimmune disorders, cardiovascular conditions, cancer, inflammatory diseases like ulcerative colitis. Ongoing research focuses on developing effective carriers tyrosine (TKIs) to enhance treatment outcomes while reducing side effects. The nano-scale drug demonstrated the ability encapsulate wide imaging therapeutic agents, enhancing tumor diagnosis treatment. Notably, incorporation drugs with poor pharmacokinetics into nanocarriers enhances their solubility stability, offering renewed opportunity assess full potential. entrapped agents can be released controlled manner maintain specific concentration within framework or triggered by stimuli such time pH target particular tissues cells. multifunctionality nanosystems offers promising avenue innovative inhibitor (TKI) delivery strategies serve alternative options cancer other diseases. This review aims provide comprehensive overview systems TKIs, standalone treatments combination approaches. We discuss comparative advantages limitations future small-molecule TKIs research.
Язык: Английский