Advances in fucoidan and fucoidan oligosaccharides: Current status, future prospects, and biological applications
Carbohydrate Polymers,
Год журнала:
2025,
Номер
unknown, С. 123559 - 123559
Опубликована: Март 1, 2025
Язык: Английский
Investigating the anti-inflammatory and anti-arthritis effects of fucoidan from a brown seaweed
Current Research in Biotechnology,
Год журнала:
2024,
Номер
7, С. 100220 - 100220
Опубликована: Янв. 1, 2024
Severe
inflammation
in
joints
caused
by
the
detrimental
effects
of
immune
system
is
termed
Rheumatoid
arthritis.
The
unconstrained
proliferation
cells
and
pro-inflammatory
cytokines
deteriorates
Synovium
which
secretes
synovial
fluid
to
lubricate
cartilage.
Non-steroidal
anti-inflammatory
drugs
(NSAIDs)
are
only
therapeutics
for
treating
rheumatoid
arthritis,
long-term
intake
causes
serious
side
on
organs.
Fucoidan,
a
sulfated
polysaccharide
found
cell
walls
brown
algae
shows
bioactive
potential.
In
our
study,
fucoidan
was
extracted
from
Padina
pavonica
(PD),
Stoechospermum
marginatum
(StM),
Spatolossum
macrodontum
(SpM),
Dictyota
bartayresiana
(DD),
Turbinaria
decurrens
(TD)
evaluated
anti-arthritis
activities.
Fucoidan
activity
vitro
using
RAW
264.7
macrophage
lines,
followed
vivo
Wistar
male
rats.
Nitric
oxide
suppression
comparatively
high
TD
(IC50
−
12.93
µg/mL).
Purified
TD,
significantly
reduced
inflammation,
size
paw
edema,
downregulated
proinflammatory
(IL-6,
IL-1β,
TNF-α),
upregulated
cytokine
(IL10)
CFA-induced
arthritis
Biochemical
parameters
like
SOD,
CAT,
GSH,
GPX,
GST
haematological
total-protein,
albumin,
haemoglobin,
RBC
were
upregulated,
other
urea,
uric
acid,
creatinine,
bilirubin,
SGOT,
SGPT,
ALP,
WBC,
ESR,
RF,
CRP
downregulated.
Histopathology
liver,
kidney,
ankle
reveals
that
restrained
tissue
damage.
Therefore,
potential
candidate
treatment
Язык: Английский
Brown algae biomass for fucoxanthin, fucoidan and alginate; update review on structure, biosynthesis, biological activities and extraction valorisation
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 135632 - 135632
Опубликована: Сен. 1, 2024
Язык: Английский
Exploring the Effects of Seaweed Synthesized Nanoparticles on Human Cancer Cell Lines
Biochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Seaweeds
can
be
found
in
either
marine
or
brackish
water
and
have
the
potential
to
bioactive.
are
important
ecological,
biological,
regenerative
components
of
maritime
environment.
Because
their
high
concentration
polysaccharides
phytochemicals,
they
sparked
a
lot
interest
domains
cosmetics,
biomass
for
fuels,
as
source
material
nanoparticle
synthesis.
Phytochemicals
seaweeds
aid
conversion
metal
ions
nanoparticles,
which
easily
overcome
tumor
micro-environment
barrier
cause
damage
cancer
cells.
In
addition,
nanotechnology-based
medicine
has
promising
therapeutic
effect
treatment.
Functionalized
nanoparticles
improve
effects
anticancer
drugs
while
also
delivering
them
site
over
time.
Metal
attention
scientific
community
use
biomedical
nanotechnology.
Drug-loaded
were
more
hazardous
cells
than
bare
drugs.
Язык: Английский
Extraction Optimization and Anti-Tumor Activity of Polysaccharides from Chlamydomonas reinhardtii
Zhongwen Liang,
Lan Xiong,
Ying Zang
и другие.
Marine Drugs,
Год журнала:
2024,
Номер
22(8), С. 356 - 356
Опубликована: Авг. 2, 2024
Chlamydomonas
reinhardtii
polysaccharides
(CRPs)
are
bioactive
compounds
derived
from
C.
reinhardtii,
yet
their
potential
in
cancer
therapy
remains
largely
unexplored.
This
study
optimized
the
ultrasound-assisted
extraction
conditions
using
response
surface
methodology
and
proceeded
with
isolation
purification
of
these
polysaccharides.
The
optimal
were
identified
as
a
sodium
hydroxide
concentration
1.5%,
ultrasonic
power
200
W,
solid-to-liquid
ratio
1:25
g/mL,
an
treatment
time
10
min,
water
bath
duration
2.5
h,
yielding
actual
rate
5.71
±
0.001%,
which
closely
aligns
predicted
value
5.639%.
Infrared
analysis
revealed
that
CRP-1
CRP-2
α-pyranose
structures
containing
furoic
acid,
while
CRP-3
CRP-4
β-pyranose
acid.
Experimental
results
demonstrated
all
four
purified
inhibited
proliferation
cervical
(HeLa)
hepatoma
(HepG-2)
colon
(HCT-116)
cells,
showing
most
significant
inhibitory
effect
on
cancer,
achieving
inhibition
rates
60.58
0.88%
40.44
1.44%,
respectively,
significantly
reducing
migration
HeLa
cells.
DAPI
staining
confirmed
inhibit
cell
by
inducing
apoptosis
has
liver
not
only
elucidates
application
but
also
provides
scientific
basis
for
further
development
utilization.
Язык: Английский
Biosynthesis and characterization of silver nanoparticles using polysaccharides from Caulerpa racemosa and evaluation of their antioxidant, antibacterial, and anticancer activities
Cholaraj Ragunath,
Karthik Madeshwaran,
Darthiqueen Paulraj
и другие.
Next Nanotechnology,
Год журнала:
2024,
Номер
6, С. 100088 - 100088
Опубликована: Янв. 1, 2024
In
recent
years,
using
biological
materials
to
synthesize
metallic
nanoparticles
has
emerged
as
an
efficient
and
cost-effective
approach.
This
work
synthesized
silver
(AgNPs)
from
Caulerpa
racemosa
(Cr)
-
Polysaccharide
(Ps).
UV–vis
spectroscopy
examined
the
synthesised
Cr-Ps-AgNPs,
revealing
a
colour
shift
surface
plasmon
resonance
peak
at
450
nm.
The
Fourier
transform
infrared
is
used
detect
functional
groups
within
polysaccharide
investigate
nanoparticle
interactions.
Scanning
Electron
Microscopy
revealed
that
biosynthesized
Cr-AgNPs
varied
in
size
32
77
X-ray
diffraction
confirmed
Cr-Ps-AgNPs
were
crystalline.
Also,
dynamic
light
scattering
showed
particles,
which
nanoparticles,
had
distribution
was
polydisperse,
with
average
diameter
of
42.8
dose-dependent
manner,
demonstrate
high
antioxidant
activity
DPPH,
reducing
power,
total
scavenging
tests.
antibacterial
against
Pseudomonas
aeruginosa,
Klebsiella
pneumonia,
Staphylococcus
aureus,
Streptococcus
pyogenes
assessed
agar
well
diffusion
test,
activity.
cytotoxicity
investigation
breast
cancer
cells
(MCF-7),
inhibitory
concentration
(IC50)
38
μg/mL.
results
this
study
show
exhibit
antioxidant,
antibacterial,
anticancer
properties.
Язык: Английский
Systematic Characteristics of Fucoidan: Intriguing Features for New Pharmacological Interventions
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11771 - 11771
Опубликована: Ноя. 1, 2024
Fucoidan,
a
sulfated
polysaccharide
found
primarily
in
brown
algae,
is
known
for
exhibiting
various
biological
activities,
many
of
which
have
been
attributed
to
its
sulfate
content.
However,
recent
advancements
techniques
analyzing
structures
highlighted
that
not
only
the
groups
but
also
composition,
molecular
weight,
and
polysaccharides
their
monomers
play
crucial
role
modulating
effects.
This
review
comprehensively
provides
monosaccharide
degree
sulfation,
weight
distribution,
linkage
glycosidic
bonds
fucoidan,
focusing
on
diversity
activities
based
characteristics.
The
implications
these
findings
future
applications
potential
therapeutic
uses
fucoidan
are
discussed.
Язык: Английский
Polysaccharide-Based Drug Carriers—A Patent Analysis
Gels,
Год журнала:
2024,
Номер
10(12), С. 801 - 801
Опубликована: Дек. 6, 2024
Polysaccharide-based
carriers
as
biomaterials
for
drug
delivery
have
been
inspiring
scientists
years
due
to
their
exceptional
characteristics,
such
nontoxicity,
biocompatibility,
and
degradability,
they
are
able
protect
pharmaceutically
active
molecules
provide
controlled/modified
release.
This
review
focuses
on
selected
systems
based
natural
polymers,
namely
fucoidan,
pullulan,
dextran,
pectin,
with
the
aim
of
highlighting
published
patent
documents.
The
information
contained
in
patents
is
very
important
because
it
usually
not
any
other
document
much
less
discussed
state
art
scientific
literature.
Espacenet—European
Patent
Office
database
International
Classification
were
used
research
highlight
specific
search
procedure.
presented
analysis
innovative
includes
an
overview
from
first
applications
latest
granted
this
field.
Язык: Английский
The Efficient Separation of Apatite from Dolomite Using Fucoidan as an Eco-Friendly Depressant
Minerals,
Год журнала:
2024,
Номер
14(9), С. 922 - 922
Опубликована: Сен. 10, 2024
The
aim
is
to
explore
new
depressants
for
achieving
the
efficient
separation
of
apatite
and
dolomite.
In
this
work,
fucoidan
(FD)
was
examined
as
an
eco-friendly
dolomite
depressant
separate
from
apatite.
depression
ability
adsorption
mechanisms
were
investigated.
flotation
results
indicated
that
FD
selectively
depressed
difference
between
reached
70%
approximately
at
concentration
75
mg/L.
Meanwhile,
recovery
grade
P2O5
89.84%
32.88%
MgO
decreased
1.64%
34.24%
in
artificially
mixed
minerals
test.
Wettability,
zeta
potential,
Fourier
transform
infrared
spectroscopy
(FTIR)
revealed
tended
adsorb
onto
dolomite,
impeding
interaction
sodium
oleate
(NaOL)
with
but
barely
affected
on
Microcalorimetry
analysis
heat
much
higher
less
time
required
achieve
equilibrium.
X-ray
photoelectron
(XPS)
proved
sulfonic
acid
radicals
within
chemically
interacted
Mg
atoms
while
it
weakly
adsorbed
Язык: Английский
Kapasitas antioksidan, sitotoksisitas dan cemaran bakteri simplisia makroalga cokelat
Jurnal Pengolahan Hasil Perikanan Indonesia,
Год журнала:
2024,
Номер
27(10), С. 899 - 916
Опубликована: Окт. 11, 2024
Alga
cokelat
merupakan
salah
satu
sumber
antioksidan
yang
dapat
berkontribusi
dalam
mempromosikan
fungsi
kesehatan.
Tujuan
penelitian
ini
adalah
untuk
menentukan
kombinasi
jenis
alga
dan
pelarut
terbaik
berdasarkan
parameter
kapasitas
antioksidan,
toksisitas
pada
sel
Vero
cemaran
bakteri
memengaruhi
simplisia
selama
30
hari
masa
simpan.
Sargassum
aquifolium
Padina
australis
dikumpulkan
dari
Pantai
Sanur
titik
surut
terendah
di
zona
intertidal.
Ekstraksi
dilakukan
menggunakan
tiga
pelarut,
yaitu
etanol,
metanol,
akuades.
Ekstrak
diukur
antioksidannya
metode
DPPH.
menunjukkan
IC50
dengan
kategori
kuat
dilanjutkan
pengujian
sitotoksisitas.
Pengujian
waktu
simpan
hari.
Hasil
ekstrak
etanol
S.
P.
(rasio
1:10)
memiliki
persentase
rendemen
sebesar
3,72%
0,935±0,003
mg/L
GAEAC
nilai
89,03
μg/mL
(kategori
kuat).
Kombinasi
konsentrasi
382,30
lemah).
Total
plate
count
(TPC),
Enterobacteriaceae,
coliform
meningkat
seiring
lama
penyimpanan
Temuan
bahwa
potensi
baik
dikembangkan
sebagai
alami.