International Immunopharmacology, Год журнала: 2022, Номер 113, С. 109449 - 109449
Опубликована: Ноя. 17, 2022
Язык: Английский
Molecules, Год журнала: 2023, Номер 28(16), С. 5979 - 5979
Опубликована: Авг. 9, 2023
Malondialdehyde (MDA) is a compound that derived from the peroxidation of polyunsaturated fatty acids. It has been used as biomarker to measure oxidative stress in various biological samples patients who are affected by wide range diseases. The aim our work provide an updated overview role MDA marker allergy-related We considered studies involving both paediatric and adult rhinitis, asthma, urticaria atopic dermatitis. measurement was performed on different types samples. reported data highlight serum inflammatory airway According literature review, status asthmatic patients, assessed via determination, appears worsen presence other allergic diseases relation disease severity. This suggests can be suitable for monitoring status. However, there several limitations due lack phenotyping description clinical period examined. In cutaneous diseases, controversial because smallness heterogeneity patients.
Язык: Английский
Процитировано
130
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(10), С. 5318 - 5318
Опубликована: Май 10, 2022
The discovery in 2006 that loss-of-function mutations the filaggrin gene (FLG) cause ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized dermatology research community shed new light on a skin protein was first identified 1981. However, although outstanding work has uncovered several key functions of epidermal homeostasis, comprehensive understanding how deficiency contributes AD is still incomplete, including details upstream factors lead reduced amounts filaggrin, regardless genotype. In this review, we re-evaluate data focusing roles epidermis, as well AD. Filaggrin important for alignment keratin intermediate filaments, control keratinocyte shape, maintenance texture via production water-retaining molecules. Moreover, leads cellular abnormalities keratinocytes induces subtle barrier impairment sufficient enough facilitate ingress certain exogenous molecules into epidermis. FLG null regulate moisture non-lesional skin, per se does not neutralization surface pH or excessive transepidermal water loss skin. Separating facts from chaff regarding epidermis necessary design efficacious therapies treat dry
Язык: Английский
Процитировано
86
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(10), С. 5518 - 5518
Опубликована: Май 15, 2022
Psoriasis (PSO) and atopic dermatitis (AD) were once considered to be mutually exclusive diseases, but gradually regarded as a spectrum of disease. Shared genetic loci both diseases noted in some populations, including Chinese. immunopathogenesis involving Th17, Th1, Th22 cells, or even IL-13 was found certain stages phenotypes. This review discusses the overlapping susceptibility, shared cytokines, immune-mediated comorbidities, clinical presentations. Overlapping conditions could classified into mainly PSO lesions with AD features vice versa, concomitant AD, disease transformation result biologics treatment.
Язык: Английский
Процитировано
48
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(7), С. 2701 - 2701
Опубликована: Апрель 4, 2023
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with high prevalence worldwide, including countries from Asia, Africa, and Latin America, in different ethnic groups. In recent years, more attention has been placed on the heterogeneity of AD associated multiple factors, patient’s background, resulting an increasing body clinical, genetic, epidemiologic, immune-phenotypic evidence that delineates differences among racial Filaggrin (FLG) mutations, strongest genetic risk factor for development AD, are detected up to 50% European 27% Asian patients, but very rarely Africans. Th2 hyperactivation attribute all groups, though endotype also characterized by increased Th17-mediated signal, whereas African Americans show strong Th2/Th22 signature absence Th1/Th17 skewing. addition, may hold important therapeutic implications as predisposition affect treatment response and, thereby, tailored strategy better targets dominant immunologic pathways each subgroup be envisaged. Nevertheless, white patients represent largest ethnicity enrolled tested clinical trials most treated real-world setting, limiting investigations about safety efficacy across ethnicities. The purpose this review describe pathophysiology ethnicities its potential implications.
Язык: Английский
Процитировано
36
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(1), С. 781 - 781
Опубликована: Янв. 2, 2023
Atopic dermatitis is a chronic, recurrent inflammatory skin disorder manifesting by eczematous lesions and intense pruritus. develops primarily as result of an epidermal barrier defect immunological imbalance. Advances in understanding these pathogenetic hallmarks, particularly the complex role interleukins atopic drivers, resulted achieving significant therapeutic breakthroughs. Novel medications involve monoclonal antibodies specifically blocking function selected small molecules such Janus kinase inhibitors limiting downstream signaling to reduce expression wider array proinflammatory factors. Nevertheless, subset patients remains refractory those treatments, highlighting complexity immunopathogenesis different populations. In this review, we address heterogeneity endotypes phenotypes present novel interleukin-oriented therapies for disease.
Язык: Английский
Процитировано
35
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11380 - 11380
Опубликована: Июль 12, 2023
Atopic dermatitis represents a complex and multidimensional interaction that potential fields of preventive therapeutic management. In addition to the treatment armamentarium available for atopic dermatitis, novel drugs targeting significant molecular pathways in biologics small molecules are also being developed given condition’s pathophysiology. While most patients expecting better efficacy long-term control, response these would still depend on numerous factors such as genotype, diverse environmental triggers microbiome-derived signals, and, importantly, dynamic immune responses. This review article highlights challenges recently pharmacological agents based pathogenesis this condition, creating specific approach toward more personalized medicine.
Язык: Английский
Процитировано
30
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(1), С. 837 - 837
Опубликована: Янв. 3, 2023
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs symptoms, growing evidence suggests AD systemic in nature. Certain diseases can possibly co-occur with as result of coincidental exposure similar environmental factors. However, it also suspected they are linked pathogenesis through more complex genetic immunological mechanisms, but these correlations remain less understood. It great need seek explanations for higher frequency number cardiovascular, autoimmune, neurological, psychiatric, metabolic disorders have been observed epidemiologic investigations among patients. Moreover, analysing immunology chronic inflammation its correction, activation, or suppression may prevent development variety comorbidities. As comorbid patients diagnosed potentially go undetected, physicians should be aware them.
Язык: Английский
Процитировано
27
Frontiers in Molecular Biosciences, Год журнала: 2023, Номер 10
Опубликована: Авг. 16, 2023
Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with various clinical presentations combinations of symptoms. The pathophysiology AD complex multifactorial. There are several factors involved in the etiopathogenesis including structural immunological epidermal barrier defect, imbalance microbiome, genetic background environmental factors. Alterations proteins, lipids, proteases, their inhibitors, lead to impairment stratum corneum which associated increased penetration transepidermal water loss. elevated serum immunoglobulin E levels blood eosinophilia have been shown majority patients. Type 2 T-helper cell immune pathway expression interleukin (IL)-4, IL-5, IL-13, has an important role AD. Both T cells keratinocytes contribute via dynamic interaction cytokines chemokines. microbiome another factor relevance It that during flares, Staphylococcus aureus (S. aureus) colonization increased, while epidermidis epidermidis) decreased. On contrary, S. species Streptococcus, Corynebacterium Propionibacterium remision phases. However, it not clear whether dysbiosis one symptoms or causes therapeutic options, targeting these pathways play critical Although topical steroids mainstay treatment AD, new biological therapies IL-4, IL-31 as well Janus kinase inhibitors (JAKi), increasingly gain more importance advances therapy In this review, we summarize dysfunction, abnormalities, filaggrin mutation options for effects on abnormalities skin.
Язык: Английский
Процитировано
24
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Март 28, 2024
As chronic inflammatory conditions driven by immune dysregulation are influenced genetics and environment factors, psoriasis atopic dermatitis (AD) have traditionally been considered to be distinct diseases characterized different T cell responses. Psoriasis, associated with type 17 helper (Th17)-mediated inflammation, presents as well-defined scaly plaques minimal pruritus. AD, primarily linked Th2-mediated poorly defined erythema, dry skin, intense itching. However, AD may overlap or transition into one another spontaneously, independent of biological agent usage. Emerging evidence suggests that defects in skin barrier-related molecules interact the polarization cells, which forms a barrier-inflammatory loop them. This contributes chronicity primary disease between AD. review aimed elucidate mechanisms underlying barrier driving In this review, importance repairing was underscored, significance tailoring biologic treatments based on individual status instead solely adhering treatment guidelines for emphasized.
Язык: Английский
Процитировано
9
JDDG Journal der Deutschen Dermatologischen Gesellschaft, Год журнала: 2024, Номер 22(1), С. 137 - 153
Опубликована: Янв. 1, 2024
Summary This S3 guideline was created based on the European guideline, with special consideration of medical conditions in German‐speaking region and incorporating additions from previous German‐language version. The interdisciplinary commission consisted representatives German Dermatological Society, Professional Association Dermatologists, Austrian Society Dermatology Venereology, Swiss for Allergology Clinical Immunology, Pediatric Adolescent Medicine, Pediatricians Environmental Rehabilitation Prevention, Psychosomatic Medicine Medical Psychotherapy, Network Health Services Research, Eczema Allergy Asthma Association. first part focuses definition diagnostic aspects atopic dermatitis (AD), addressing topical therapy as well non‐pharmacological treatment approaches such UV therapy, psychoeducational dietary interventions AD, allergen immunotherapy complementary medicine. also covers specific AD children adolescents, during pregnancy lactation, context family planning. Additionally, it addresses occupational highlights perspective patients. second published separately, systemic AD.
Язык: Английский
Процитировано
8