Developing Heterogeneous Porous 3D-Printed SiO2-Pd-K2SiO3 Monolithic Catalyst via Surface MOF Growth and Pyrolysis for the Synthesis of Antitumoral Isatins DOI Creative Commons
Alexandrina Druta,

Rania Bouhmala,

Teqwa Ragdi

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 505 - 505

Опубликована: Апрель 11, 2025

Background/Objectives: The isatin nucleus is a privileged scaffold in drug discovery, particularly due to its proven relevance anticancer research. Developing reusable heterogeneous 3D catalysts for synthesis represents critical challenge both industrial and academic contexts. This multi interdisciplinary work aimed design synthesize novel 3D-printed silica-based porous catalyst functionalized with palladium, evaluate catalytic performance synthesis, assess the antiproliferative activity of resulting compounds against tumor cell lines such as HeLa, MCF-7, MDA-MB231. Methods: multifaceted approach synthesizing this involved surface growth metal–organic framework (ZIF-8) on silica support, followed by potassium silicate coating pyrolysis. Results: After detailed physicochemical characterization, was tested challenging “double” palladium-catalyzed cross-coupling reactions (Suzuki, Stille, Heck), demonstrating robustness, reusability, high efficiency producing bis-1,5-aryl, alkynyl, alkenyl-isatin derivatives. Importantly, no leaching palladium species detected during cycles, further underscoring stability system. These isatin-based exhibited remarkable cytotoxicity, selective molecules achieving nanomolar potency MCF-7 cells, surpassing reference drugs doxorubicin sunitinib. Conclusions: study not only introduces strategy fabricating from sintered surfaces but also highlights new biomolecules promising applications cancer

Язык: Английский

Developing Heterogeneous Porous 3D-Printed SiO2-Pd-K2SiO3 Monolithic Catalyst via Surface MOF Growth and Pyrolysis for the Synthesis of Antitumoral Isatins DOI Creative Commons
Alexandrina Druta,

Rania Bouhmala,

Teqwa Ragdi

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 505 - 505

Опубликована: Апрель 11, 2025

Background/Objectives: The isatin nucleus is a privileged scaffold in drug discovery, particularly due to its proven relevance anticancer research. Developing reusable heterogeneous 3D catalysts for synthesis represents critical challenge both industrial and academic contexts. This multi interdisciplinary work aimed design synthesize novel 3D-printed silica-based porous catalyst functionalized with palladium, evaluate catalytic performance synthesis, assess the antiproliferative activity of resulting compounds against tumor cell lines such as HeLa, MCF-7, MDA-MB231. Methods: multifaceted approach synthesizing this involved surface growth metal–organic framework (ZIF-8) on silica support, followed by potassium silicate coating pyrolysis. Results: After detailed physicochemical characterization, was tested challenging “double” palladium-catalyzed cross-coupling reactions (Suzuki, Stille, Heck), demonstrating robustness, reusability, high efficiency producing bis-1,5-aryl, alkynyl, alkenyl-isatin derivatives. Importantly, no leaching palladium species detected during cycles, further underscoring stability system. These isatin-based exhibited remarkable cytotoxicity, selective molecules achieving nanomolar potency MCF-7 cells, surpassing reference drugs doxorubicin sunitinib. Conclusions: study not only introduces strategy fabricating from sintered surfaces but also highlights new biomolecules promising applications cancer

Язык: Английский

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