Tailored Pore Architectures in Ti6Al4V Bone Scaffolds for Tunable Permeability and Mechanical Performance DOI
Chao Xu, Yulin Zhang, Lu Zhang

и другие.

Advanced Engineering Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

To achieve multifunctionalities such as nutrient transport, cellular activities, and load‐bearing while avoiding stress shielding, bone tissue engineering scaffolds must exhibit consistent permeability mechanical properties comparable to those of human bones. Here, filament‐rotated, filament‐shifted, gradient, conventional Ti6Al4V are designed fabricated using direct ink writing. These high‐precision interconnective pores simultaneously match the elastic modulus with trabeculae. The impact internal pore architecture on is investigated systematically through experimental numerical methods. Compared scaffolds, alterations in structure result decreased modulus. influence porosity scaffold outweighs that architecture. shifted 100% exhibits a more uniform symmetrical distribution wall shear stress, which may promote cell adhesion proliferation. By tuning diverse architectures, wide range (e.g., values 1.12 × 10 −10 2.95 m 2 ) property moduli 1.0–5.7 GPa) can be achieved. A hierarchical, goal‐oriented selection framework proposed guide structural design patient‐specific across various anatomical sites.

Язык: Английский

The mussel-inspired GelMA/dopamine/hyaluronic acid composite hydrogel dressing for wet surface adhesion DOI
Xiangnan Zhang,

Huershan Wusiman,

Yahui Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140448 - 140448

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Organoid Vascularization: Strategies and Applications DOI
Qianmin Gao, Jian Wang, Hao Zhang

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Organoids provide 3D structures that replicate native tissues in biomedical research. The development of vascular networks within organoids enables oxygen and nutrient delivery while facilitating metabolic waste removal, which supports organoid growth maturation. Recent studies demonstrate vascularized models offer insights into tissue interactions promote regeneration. However, the current limitations establishing functional affect growth, viability, clinical translation potential. This review examines organoids, including mechanisms angiogenesis vasculogenesis, construction strategies, applications. approaches are categorized vivo vitro methods, with analysis their specific advantages limitations. also discusses emerging techniques such as bioprinting gene editing for improving vascularization integration organoid‐based therapies. Current developments indicate potential applications modeling human diseases developing therapeutic contributing to advances translational

Язык: Английский

Процитировано

0
Tailored Pore Architectures in Ti6Al4V Bone Scaffolds for Tunable Permeability and Mechanical Performance DOI
Chao Xu, Yulin Zhang, Lu Zhang

и другие.

Advanced Engineering Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

To achieve multifunctionalities such as nutrient transport, cellular activities, and load‐bearing while avoiding stress shielding, bone tissue engineering scaffolds must exhibit consistent permeability mechanical properties comparable to those of human bones. Here, filament‐rotated, filament‐shifted, gradient, conventional Ti6Al4V are designed fabricated using direct ink writing. These high‐precision interconnective pores simultaneously match the elastic modulus with trabeculae. The impact internal pore architecture on is investigated systematically through experimental numerical methods. Compared scaffolds, alterations in structure result decreased modulus. influence porosity scaffold outweighs that architecture. shifted 100% exhibits a more uniform symmetrical distribution wall shear stress, which may promote cell adhesion proliferation. By tuning diverse architectures, wide range (e.g., values 1.12 × 10 −10 2.95 m 2 ) property moduli 1.0–5.7 GPa) can be achieved. A hierarchical, goal‐oriented selection framework proposed guide structural design patient‐specific across various anatomical sites.

Язык: Английский

Процитировано

0