Hepatoprotective activity of Taraxacum officinale extract against CCl4-induced Liver injury in rats
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106708 - 106708
Опубликована: Апрель 1, 2025
Язык: Английский
Excessive caffeine intake inhibits steroidogenesis, folliculogenesis and disrupts utero-ovarian tissue histomorphology integrity in experimental rats, and precipitates polycystic ovary syndrome in Sprague-Dawley rats
Food Chemistry Advances,
Год журнала:
2024,
Номер
4, С. 100678 - 100678
Опубликована: Март 16, 2024
Polycystic
ovarian
syndrome
(PCOS)
is
characterized
by
anovulation
and
hyperandrogenism
symptoms.
Caffeine
popularly
consumed
it
a
legal
psychoactive
substance.
This
study
evaluated
the
effect
of
excessive
caffeine
intake
on
utero-ovarian
tissue
in
polycystic
ovary
rats.
Twenty-four
female
rats
randomized
into
group
A
control
received
2
ml
normal
saline.
Group
B
4
mg/kg
body
weight
(bwt)
i.p
estradiol
valerate
(EV)
first
day,
C
100
bwt
orally,
D
EV
orally.
The
experiment
lasted
30
days.
Histology
uterus,
oxidative
antioxidant,
reproductive
hormone,
lipid
profile,
inflammatory
markers,
apoptosis
markers
were
evaluated.
histoarchitecture
revealed
degeneration
theca
cells,
granulosa,
corpus
luteum,
loss
mucin
granules
uterine
tissues
PCOS,
CAF,
PCO+CAF.
estrous
cycle
became
irregular,
with
prolonged
diestrous
proestrus
phases.
Marked
rise
decline
activities
enzymatic
antioxidants,
response,
caspase-dependent
apoptosis,
hormonal
imbalance.
Excessive
consumption,
therefore
impaired
integrity,
hormones,
indicators,
oxidant
antioxidant
parameters,
apoptotic
cycle.
Язык: Английский
Neurotherapeutic potential of sinapic acid in cerebellar neurotoxicity induced following excessive exposure to tramadol hydrochloride in male Sprague Dawley rats
Deleted Journal,
Год журнала:
2025,
Номер
unknown, С. 200217 - 200217
Опубликована: Апрель 1, 2025
Язык: Английский
Computational insights into the anti-diabetic potential of Albizia antunesiana (Mimosaceae) metabolites: A molecular docking, drug-likeness and ADMET analysis
Results in Chemistry,
Год журнала:
2025,
Номер
unknown, С. 102422 - 102422
Опубликована: Июнь 1, 2025
Язык: Английский
Metformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus-induced renal injury in male Wistar rats
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
Язык: Английский
Neuroprotective mechanisms and ameliorative activities of quercetin in cisplatin-induced cerebellum neurotoxicity in rat models
Brain Disorders,
Год журнала:
2024,
Номер
unknown, С. 100166 - 100166
Опубликована: Окт. 1, 2024
Язык: Английский
BCL-2 and BAX expression and Germ cell apoptosis following the intervention of 1-isothiocyanato-4-methylsulfinylbutane in cisplatin-induced testicular toxicity and sperm DNA fragmentation in Sprague-Dawley rat
Aspects of Molecular Medicine,
Год журнала:
2024,
Номер
unknown, С. 100055 - 100055
Опубликована: Окт. 1, 2024
Язык: Английский