Circulating Autoantibodies Against Vasoactive Biomarkers Related to Orthostatic Intolerance in Long COVID Patients Compared to No-Long-COVID Populations: A Case-Control Study

Biomolecules, Год журнала: 2025, Номер 15(2), С. 300 - 300

Опубликована: Фев. 18, 2025

Endothelial dysfunction mediated by elevated levels of autoantibodies against vasoactive peptides occurring after COVID-19 infection is proposed as a possible pathomechanism for orthostatic intolerance in long COVID patients. This case-control study comprised 100 patients from our prospective POSTCOV registry and three control groups, each consisting 20 individuals (Asymptomatic post-COVID group; Healthy group = pan-negative antispike protein SARS-CoV-2; Vaccinated healthy no history vaccinated). Autoantibodies towards muscarinic acetylcholine receptor M3, endothelin type A (ETAR), beta-2 adrenergic (Beta-2 AR), angiotensin II 1 1-7 (Ang1-7) concentrations were measured enzyme-linked immunosorbent assay controls. Orthostatic was defined inappropriate sinus tachycardia, postural hypotonia other dysautonomia symptoms, such dizziness or blurred vision (n 38 patients). Autoantibody compared with routine laboratory parameters quality life questionnaires (EQ-5D). The concentration ETAR significantly higher COVID, Asymptomatic groups to the group. trend plasma Beta-2 AR Ang1-7 patients, not related presence intolerance. autoantibody showed significant positive correlation EQ-5D item "Problems performing usual activities".

Язык: Английский

Post-pandemic, long COVID persists

Annals of Allergy Asthma & Immunology, Год журнала: 2024, Номер 133(5), С. 489 - 490

Опубликована: Ноя. 1, 2024

Язык: Английский

Intravenous immunglobulin as a therapy for autoimmune conditions

Autoimmunity Reviews, Год журнала: 2024, Номер unknown, С. 103710 - 103710

Опубликована: Ноя. 1, 2024

Язык: Английский