Management of Patients With EGFR Exon 20–Mutant Advanced Non–Small Cell Lung Cancer DOI
Lova Sun, Melina E. Marmarelis, Charu Aggarwal

и другие.

Journal of Clinical Oncology, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation followed by a description of diagnostic and management challenges, review relevant literature, summary authors' suggested approaches. goal this help readers better understand how apply results key studies, including those Clinical Oncology, patients seen their own practice.

Язык: Английский

Tepotinib plus osimertinib in patients with EGFR-mutated non-small-cell lung cancer with MET amplification following progression on first-line osimertinib (INSIGHT 2): a multicentre, open-label, phase 2 trial DOI
Yi‐Long Wu, Valentina Guarneri, Pei Jye Voon

и другие.

The Lancet Oncology, Год журнала: 2024, Номер 25(8), С. 989 - 1002

Опубликована: Июль 29, 2024

Язык: Английский

Процитировано

23

Therapy for Stage IV Non–Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2024.1 DOI
Dwight H. Owen, Nofisat Ismaila, Janet Freeman‐Daily

и другие.

Journal of Clinical Oncology, Год журнала: 2024, Номер 42(20), С. e44 - e59

Опубликована: Май 30, 2024

.

Процитировано

21

Datopotamab Deruxtecan in Advanced or Metastatic Non–Small Cell Lung Cancer With Actionable Genomic Alterations: Results From the Phase II TROPION-Lung05 Study DOI Creative Commons
Jacob Sands, Myung‐Ju Ahn, Aaron Lisberg

и другие.

Journal of Clinical Oncology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

PURPOSE Datopotamab deruxtecan (Dato-DXd) is a trophoblast cell-surface antigen-2–directed antibody-drug conjugate with highly potent topoisomerase I inhibitor payload. The TROPION-Lung05 phase II trial (ClinicalTrials.gov identifier: NCT04484142 ) evaluated the safety and clinical activity of Dato-DXd in patients advanced/metastatic non–small cell lung cancer (NSCLC) actionable genomic alterations progressing on or after targeted therapy platinum-based chemotherapy. PATIENTS AND METHODS Patients received 6 mg/kg once every 3 weeks. primary end point was objective response rate (ORR) by blinded independent central review. Secondary points included duration (DOR), safety, tolerability, survival. RESULTS Among 137 who at least 1 dose Dato-DXd, 71.5% three lines prior therapies for disease. Overall, 56.9% had EGFR mutations 24.8% ALK rearrangements. Median treatment 4.4 months (range, 0.7-20.6). confirmed ORR 35.8% (95% CI, 27.8 to 44.4) overall, 43.6% 32.4 55.3) 23.5% 10.7 41.2) those rearrangements, respectively. median DOR 7.0 4.2 9.8), overall disease control 78.8% 71.0 85.3). Grade ≥3 treatment-related adverse events (TRAEs) occurred 28.5% patients. most common TRAE stomatitis (preferred term; any grade: 56.2%; grade ≥3: 9.5%). Five (3.6%) experienced adjudicated interstitial disease/pneumonitis, (0.7%) 5 event. CONCLUSION Encouraging durable antitumor observed this heavily pretreated NSCLC population alterations. toxicities comparable previous observations, no new signals were observed.

Язык: Английский

Процитировано

9

Results from a phase 1b study of telisotuzumab vedotin in combination with osimertinib in patients with c-Met protein–overexpressing, EGFR-mutated locally advanced/metastatic non-small cell lung cancer (NSCLC) after progression on prior osimertinib DOI

H. Horinouchi,

B.C. Cho,

D.R. Camidge

и другие.

Annals of Oncology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

4

Lazertinib: Breaking the mold of third-generation EGFR inhibitors DOI Creative Commons

Kishan B. Patel,

David E. Heppner

RSC Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Small molecules targeting activating mutations within the epidermal growth factor receptor (EGFR) are efficacious anticancer agents, particularly in non-small cell lung cancer (NSCLC).

Язык: Английский

Процитировано

3

Update 2025: Management of Non‑Small-Cell Lung Cancer DOI Creative Commons
Hyein Jeon, Shuai Wang, Junmin Song

и другие.

Lung, Год журнала: 2025, Номер 203(1)

Опубликована: Март 25, 2025

Lung cancer remains the leading cause of cancer-related mortality worldwide. Since 2024, non-small-cell lung (NSCLC) landscape has undergone a transformative shift, driven by 11 FDA approvals. Recent advances in molecular profiling, targeted therapies, and immunotherapies have revolutionized NSCLC management, ushering an era personalized treatment with improved patient outcomes. The increased adoption low-dose computed tomography (LDCT) for screening enhanced early detection, enabling intervention at more curable stages. Molecular diagnostics now play pivotal role guiding strategies, actionable genomic alterations (AGAs) informing use EGFR, ALK, ROS1, KRAS, NRG1, other inhibitors both advanced settings. For instance, therapies are increasingly being integrated into early-stage adjuvant osimertinib EGFR-mutated alectinib ALK-positive demonstrating substantial survival benefits. Immunotherapy, particularly immune checkpoint inhibitors, become cornerstone AGA-negative NSCLC, either as monotherapy or combination chemotherapy, is utilized perioperative setting. Furthermore, emerging such bispecific antibodies, antibody-drug conjugates (ADCs), novel immunotherapeutic agents show promise addressing resistance mechanisms improving outcomes advanced-stage disease. Although new challenges arise, evolving paradigm continues to prioritize precision medicine, offering hope prolonged quality life patients.

Язык: Английский

Процитировано

3

ctDNA for the Evaluation and Management of EGFR-Mutant Non-Small Cell Lung Cancer DOI Open Access
Aakash Desai, Tadana A. Vázquez,

Keishla M. Arce

и другие.

Cancers, Год журнала: 2024, Номер 16(5), С. 940 - 940

Опубликована: Фев. 26, 2024

Circulating tumor DNA (ctDNA) offers a new paradigm in optimizing treatment strategies for epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). Its potential spans early-stage disease, influencing adjuvant therapy, to advanced where it aids identifying genomic markers and resistance mechanisms. This review explores the evolving landscape of utilizing liquid biopsies, specifically circulating (ctDNA), management NSCLC with

Язык: Английский

Процитировано

16

Advancements in fourth-generation EGFR TKIs in EGFR-mutant NSCLC: Bridging biological insights and therapeutic development DOI
Carla Corvaja, Antonio Passaro, Ilaria Attili

и другие.

Cancer Treatment Reviews, Год журнала: 2024, Номер 130, С. 102824 - 102824

Опубликована: Сен. 4, 2024

Язык: Английский

Процитировано

13

Impact of EML4-ALK Variants and Co-Occurring TP53 Mutations on Duration of First-Line ALK Tyrosine Kinase Inhibitor Treatment and Overall Survival in ALK Fusion-Positive NSCLC: Real-World Outcomes From the GuardantINFORM database DOI Creative Commons
Kaushal Parikh, Anastasios Dimou, Konstantinos Leventakos

и другие.

Journal of Thoracic Oncology, Год журнала: 2024, Номер 19(11), С. 1539 - 1549

Опубликована: Июль 16, 2024

Язык: Английский

Процитировано

11

The changing treatment landscape of EGFR-mutant non-small-cell lung cancer DOI
Fei Zhou, Haoyue Guo, Yang Xia

и другие.

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

11