International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 86 - 86
Опубликована: Дек. 26, 2024
Alcohol-associated
liver
disease
(ALD)
is
a
common
non-communicable
chronic
characterized
by
spectrum
of
conditions
ranging
from
steatosis
and
alcohol-associated
steatohepatitis
(AH)
to
fibrosis,
cirrhosis,
hepatocellular
carcinoma
(HCC).
The
pathogenesis
ALD
involves
complex
interplay
various
molecular,
biochemical,
genetic,
epigenetic,
environmental
factors.
While
the
mechanisms
are
well
studied,
therapeutic
options
remain
limited.
Alpinetin,
natural
flavonoid
with
antioxidant
anti-inflammatory
properties,
has
shown
potential
hepatoprotective
effects,
though
its
efficacy
in
remains
unexplored.
This
study
investigated
effects
alpinetin
using
Lieber–DeCarli
ethanol
liquid
diet
model
C57BL/6
mice.
Mice
were
divided
into
three
groups:
control
group,
group
treated
alpinetin.
Serum
activity
ALT,
AST,
γ-GT,
ALP
was
measured
assess
function,
along
antioxidative
oxidative/nitrosative
stress
markers
tissue.
Pro-inflammatory
cytokines
endoplasmic
reticulum
(ER)
parameters
tissue
also
evaluated.
Histological
assessment
performed
SALVE
grading
staging
system.
Treatment
significantly
reduced
serum
levels
while
increasing
markers.
pro-inflammatory
ER
decreased.
analysis
demonstrated
steatosis,
hepatocyte
ballooning,
inflammation.
These
findings
suggest
that
holds
promise
as
agent
for
managing
ALD.
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(35), С. 3965 - 3971
Опубликована: Сен. 12, 2024
In
this
editorial,
we
examine
a
paper
by
Koizumi
et
al
,
on
the
role
of
peroxisome
proliferator-activated
receptor
(PPAR)
agonists
in
alcoholic
liver
disease
(ALD).
The
study
determined
whether
elafibranor
protected
intestinal
barrier
and
reduced
fibrosis
mouse
model
ALD.
also
underlines
PPARs
function
lipid
homeostasis,
which
are
both
affected
Effective
therapies
necessary
for
ALD
because
it
is
critical
health
issue
that
affects
people
worldwide.
This
editorial
analyzes
possibility
PPAR
as
treatments
As
key
factors
inflammation
metabolism,
offer
multiple
methods
managing
complex
etiology
We
assess
abilities
PPARα,
PPARγ,
PPARβ/δ
to
prevent
steatosis,
inflammation,
due
diseases.
Recent
research
carried
out
preclinical
clinical
settings
has
shown
can
reduce
severity
disease.
discusses
data
analyzed
obstacles,
advantages,
mechanisms
action
Further
needed
understand
efficacy,
safety,
treating
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 86 - 86
Опубликована: Дек. 26, 2024
Alcohol-associated
liver
disease
(ALD)
is
a
common
non-communicable
chronic
characterized
by
spectrum
of
conditions
ranging
from
steatosis
and
alcohol-associated
steatohepatitis
(AH)
to
fibrosis,
cirrhosis,
hepatocellular
carcinoma
(HCC).
The
pathogenesis
ALD
involves
complex
interplay
various
molecular,
biochemical,
genetic,
epigenetic,
environmental
factors.
While
the
mechanisms
are
well
studied,
therapeutic
options
remain
limited.
Alpinetin,
natural
flavonoid
with
antioxidant
anti-inflammatory
properties,
has
shown
potential
hepatoprotective
effects,
though
its
efficacy
in
remains
unexplored.
This
study
investigated
effects
alpinetin
using
Lieber–DeCarli
ethanol
liquid
diet
model
C57BL/6
mice.
Mice
were
divided
into
three
groups:
control
group,
group
treated
alpinetin.
Serum
activity
ALT,
AST,
γ-GT,
ALP
was
measured
assess
function,
along
antioxidative
oxidative/nitrosative
stress
markers
tissue.
Pro-inflammatory
cytokines
endoplasmic
reticulum
(ER)
parameters
tissue
also
evaluated.
Histological
assessment
performed
SALVE
grading
staging
system.
Treatment
significantly
reduced
serum
levels
while
increasing
markers.
pro-inflammatory
ER
decreased.
analysis
demonstrated
steatosis,
hepatocyte
ballooning,
inflammation.
These
findings
suggest
that
holds
promise
as
agent
for
managing
ALD.
