Recent Advances in Smart Polymeric Micelles for Targeted Drug Delivery

Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(4)

Опубликована: Апрель 1, 2025

ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.

Язык: Английский

Bioactive hemostatic materials: a new strategy for promoting wound healing and tissue regeneration

MedComm, Год журнала: 2025, Номер 6(4)

Опубликована: Март 22, 2025

Abstract Wound healing remains a critical global healthcare challenge, with an annual treatment cost exceeding $50 billion worldwide. Over the past decade, significant advances in wound care have focused on developing sophisticated biomaterials that promote tissue regeneration and prevent complications. Despite these developments, there crucial need for multifunctional materials can effectively address complex, multiphase nature of repair while being effective easily applicable various clinical settings. This review systematically analyzes latest developments materials, examining their chemical composition, structural design, therapeutic mechanisms. We comprehensively evaluate bioactive components, including natural polymers, synthetic matrices, hybrid composites, along different forms, such as hydrogels, powders, smart dressings. Special attention is given to emerging strategies material design integrate multiple functions, sustained drug delivery, infection prevention, promotion. The insights provided this illuminate path toward next‐generation highlighting opportunities more solutions significantly improve patient outcomes reduce burden.

Язык: Английский

Injectable and In Situ Phospholipid-Based Phase Separation Gel for Sustained Delivery of Altrenogest

Gels, Год журнала: 2024, Номер 10(12), С. 847 - 847

Опубликована: Дек. 23, 2024

Altrenogest is a key regulatory hormone for intensive and batch management of reserve sows in breeding farms. As synthetic hormone, altrenogest could make ovaries stay at the initial stage follicles inhibit estrus ovulation animals. However, currently used oral solution needs to be administered continuously every day more than two weeks clinical practice. In this study we developed phospholipid-based injectable gel carrying decrease number administrations, sustain release drug, enhance therapeutic efficacy use. The had viscosity 100 cP before phase transition over 1,000,000 after transition. vitro, can released from weeks. pharmacokinetic results showed that AUC (0–∞) was almost double solution. MRT 40.92 ± 7.21 h t1/2 80.03 20.79 h. demonstrated excellent fluidity, ease injectability, high drug-loading capacity, appropriate sustained-release characteristics both vitro vivo, making it potential drug delivery system swine production.

Язык: Английский