The effects of carotid plaque classification and bifurcation angle on plaque: a computational fluid dynamics simulation DOI Creative Commons
Ai Chen, Zhuo Chen,

Jun Su

и другие.

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Март 21, 2025

Objectives To investigate the influence of plaque distribution and vascular bifurcation angle on hemodynamics within carotid artery to explore role these factors play in development vulnerable plaques. The study aims provide a more comprehensive understanding how complex hemodynamic patterns affect formation, vulnerability, progression. Methods Patient-specific models were reconstructed using 3D rotational angiography CT angiography, validated by digital subtraction angiography. Computational fluid dynamics (ANSYS Fluent) with non-Newtonian modeling simulated under patient-specific boundary conditions. Plaque morphology parameters (TAWSS, OSI, ECAP) quantified. Statistical analyses included Spearman’s correlations non-parametric tests for angles/plaque locations. Results Numerical simulations demonstrated that subtypes angles critically modulate hemodynamics. Elevated wall shear stress (WSS) upstream plaques (sites M/N) increased rupture susceptibility, whereas low WSS at outer (site P) exacerbated atherogenesis. Larger reduced peak velocities, expanded low-velocity zones, diminished WSS, amplifying atherosclerosis risk. Vortex-driven low-shear regions prolonged platelet residence, enhancing thrombotic propensity. Fluid-structure interactions revealed arterial deformation near bifurcations, correlating endothelial injury These alterations underscore biomechanical interplay driving vulnerability thrombosis atherosclerosis. Conclusion Carotid arises from angle-dependent disturbances, where elevated predisposes rupture, while zones accelerate retention fluid-structure exacerbate dysfunction, underscoring targeting clinical risk mitigation.

Язык: Английский

The effects of carotid plaque classification and bifurcation angle on plaque: a computational fluid dynamics simulation DOI Creative Commons
Ai Chen, Zhuo Chen,

Jun Su

и другие.

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Март 21, 2025

Objectives To investigate the influence of plaque distribution and vascular bifurcation angle on hemodynamics within carotid artery to explore role these factors play in development vulnerable plaques. The study aims provide a more comprehensive understanding how complex hemodynamic patterns affect formation, vulnerability, progression. Methods Patient-specific models were reconstructed using 3D rotational angiography CT angiography, validated by digital subtraction angiography. Computational fluid dynamics (ANSYS Fluent) with non-Newtonian modeling simulated under patient-specific boundary conditions. Plaque morphology parameters (TAWSS, OSI, ECAP) quantified. Statistical analyses included Spearman’s correlations non-parametric tests for angles/plaque locations. Results Numerical simulations demonstrated that subtypes angles critically modulate hemodynamics. Elevated wall shear stress (WSS) upstream plaques (sites M/N) increased rupture susceptibility, whereas low WSS at outer (site P) exacerbated atherogenesis. Larger reduced peak velocities, expanded low-velocity zones, diminished WSS, amplifying atherosclerosis risk. Vortex-driven low-shear regions prolonged platelet residence, enhancing thrombotic propensity. Fluid-structure interactions revealed arterial deformation near bifurcations, correlating endothelial injury These alterations underscore biomechanical interplay driving vulnerability thrombosis atherosclerosis. Conclusion Carotid arises from angle-dependent disturbances, where elevated predisposes rupture, while zones accelerate retention fluid-structure exacerbate dysfunction, underscoring targeting clinical risk mitigation.

Язык: Английский

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