Surface‐Engineered Vanadium Carbide MXenzyme for Anti‐Inflammation and Photoenhanced Antitumor Therapy of Colon Diseases

Advanced Functional Materials, Год журнала: 2023, Номер 33(31)

Опубликована: Апрель 28, 2023

Abstract The development of colitis‐associated colorectal cancer is known to be associated with the inflammation‐dysplasia‐carcinoma pathway, and thus, chronic inflammation represents an inducer promoter cancer. To inhibit evolution from colitis provide efficient anticancer therapy, a surface‐engineered vanadium carbide MXene nanoenzyme (MXenzyme) developed both amino functionalization gallium doping (Ga/V 2 C‐NH ). Benefiting multiple enzyme‐mimicking activities, MXenzymes have shown great potential decrease excessive reactive oxygen species levels proinflammatory cytokines, resulting in good anti‐inflammatory effects on dextran sulfate sodium‐induced acute colitis. Moreover, gallium‐doped amino‐functionalized surface can mediate improved MXene‐tumor interactions inhibitory cell proliferation, achieving precise chemo‐photothermal therapy. Elemental into also highlighted as feasible strategy achieve loading controlled release gallium. As result, complete tumor ablation without further recurrence observed for colon cancer‐bearing mice that receive Ga/V near infrared irradiation, while MXenzyme system displays excellent biocompatibility at cellular animal levels. These findings not only enrich research MXene, but illustrate its therapeutic promise anti‐inflammation photoenhanced antitumor therapy diseases.

Язык: Английский

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From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy

Bioactive Materials, Год журнала: 2023, Номер 31, С. 206 - 230

Опубликована: Авг. 14, 2023

Traditional cancer therapy methods, especially those directed against specific intracellular targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity and therapeutic resistance. Oncolytic peptides that can induce membrane lysis-mediated cell death subsequent anticancer immune responses, has provided a new paradigm for therapy. However, the clinical application of oncolytic is always limited by some factors such as unsatisfactory bio-distribution, poor stability, off-target toxicity. To these limitations, polymers stand out prospective materials owing their high chemical versatility, scalable production capacity, which potential drive revolution in treatment. This review provides an overview mechanism structure-activity relationship peptides. Then peptides-mediated combination nano-delivery strategies summarized. Emphatically, current research progress been highlighted. Lastly, challenges prospects development discussed.

Язык: Английский

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Design Methods for Antimicrobial Peptides with Improved Performance

动物学研究, Год журнала: 2023, Номер 0(0), С. 0 - 0

Опубликована: Янв. 1, 2023

The Recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more difficult. In this regard, developing new antimicrobial agents combat antibiotic-resistant strains become a top priority. Antimicrobial peptides (AMPs), ubiquitous class naturally occurring compounds with broad-spectrum anti-pathogen activity, hold significant promise as one the most effective solutions current resistance (AMR) crisis. Several AMPs have been identified evaluated for their therapeutic application, many already in drug development pipeline. Their distinct properties, such high target specificity, potency, ability bypass microbial mechanisms, make them promising alternative antibiotics. Nonetheless, several challenges, toxicity, lability proteolytic degradation, low stability, poor pharmacokinetics, production costs, continue hamper clinical applicability. Therefore, much recent research focused on optimizing peptides' properties improve performance. By understanding physiochemical AMPs, amphipathicity, hydrophobicity, structural conformation, amino acid distribution, composition, that correspond researchers can design desired improved review, we highlight some key strategies, rational de novo design, used optimize performance AMPs. We also discuss how evolution predictive computational tools technologies utilize artificial intelligence machine learning are increasingly being synthesize lead candidates efficacy.

Язык: Английский

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Harnessing antimicrobial peptide-coupled photosensitizer to combat drug-resistant biofilm infections through enhanced photodynamic therapy

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 14(4), С. 1759 - 1771

Опубликована: Дек. 30, 2023

Bacterial biofilm-associated infection was one of the most serious threats to human health. However, effective drugs for drug-resistance bacteria or biofilms remain rarely reported. Here, we propose an innovative strategy develop a multifunctional antimicrobial agent with broad-spectrum antibacterial activity by coupling photosensitizers (PSs) peptides (AMPs). This capitalizes on ability PSs generate reactive oxygen species (ROS) and membrane-targeting property AMPs (KRWWKWIRW, peptide screened artificial neural network), synergistically enhancing activity. In addition, unlike conventional aggregation-caused quenching (ACQ) photosensitizers, aggregation-induced emission (AIE) show stronger fluorescence in aggregated state help visualize mechanism. vitro experiments demonstrated excellent killing effects developed against both Gram-positive (G+) Gram-negative (G–) bacteria. The bacterial-aggregations induced enhanced photoactivatable G– Notably, it exhibited significant effect destroying MRSA biofilms. Moreover, also showed remarkable efficacy treating wound infections mice vivo. holds potential addressing challenges posed bacterial drug-resistant

Язык: Английский

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Development of cannabidiol derivatives as potent broad-spectrum antibacterial agents with membrane-disruptive mechanism

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 266, С. 116149 - 116149

Опубликована: Янв. 17, 2024

Язык: Английский

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Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives

Nanoscale, Год журнала: 2024, Номер 16(6), С. 2820 - 2833

Опубликована: Янв. 1, 2024

In this review, we provide a comprehensive overview and analysis of the current advancements in nanomedicines for targeted pulmonary delivery.

Язык: Английский

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Epsilon-poly-l-lysine microneedle patch loaded with amorphous doxycycline nanoparticles for synergistic treatment of skin infection

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 266, С. 131383 - 131383

Опубликована: Апрель 4, 2024

Язык: Английский

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Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Май 26, 2022

The search for efficient antimicrobial therapies that can alleviate suffering caused by infections from resistant bacteria is more urgent than ever before. Infections multi-resistant pathogens represent a significant and increasing burden to healthcare society researcher are investigating new classes of bioactive compounds slow down this development. Antimicrobial peptides the innate immune system one promising class offers potential solution antibiotic resistance problem due their mode action on microbial membranes. However, challenges associated with pharmacokinetics, bioavailability off-target toxicity slowing advancement use defensive peptides. Improving therapeutic properties these strategy reducing clinical limitations synthetic mimics emerging as molecules variety applications. These be made significantly shorter while maintaining, or even improving properties, several downsized now in development range infectious diseases. A strategies employed prepare small review describes different developed date adhering minimum pharmacophore based an amphiphilic balance between cationic charge hydrophobicity. dipeptides, circumventing need large elaborate three-dimensional structures generate simplified potent medical This highlight key recent field peptide antimicrobials, illustrating just how you go.

Язык: Английский

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Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(11), С. 6108 - 6108

Опубликована: Май 29, 2022

In the last few years, antibiotic resistance and, analogously, anticancer drug have increased considerably, becoming one of main public health problems. For this reason, it is crucial to find therapeutic strategies able counteract onset multi-drug (MDR). review, a critical overview innovative tools available today fight MDR reported. direction, use membrane-disruptive peptides/peptidomimetics (MDPs), such as antimicrobial peptides (AMPs), has received particular attention, due their high selectivity and limited side effects. Moreover, similarities between bacteria cancer cells are herein reported hypothesis possible AMPs also in therapies discussed. However, important take into account limitations that could negatively impact clinical application particular, need for an efficient delivery system. regard, nanoparticles (NPs) proposed potential strategy improve therapy; moreover, among polymeric NPs, cationic ones emerging promising both cells.

Язык: Английский

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The limits of prediction: Why intrinsically disordered regions challenge our understanding of antimicrobial peptides

Computational and Structural Biotechnology Journal, Год журнала: 2024, Номер 23, С. 972 - 981

Опубликована: Фев. 12, 2024

Antimicrobial peptides (AMPs) are molecules found in most organisms, playing a vital role innate immune defense against pathogens. Their mechanism of action involves the disruption bacterial cell membranes, causing leakage cellular contents and ultimately leading to death. While AMPs typically lack defined structure solution, they often assume conformation when interacting with membranes. Given this structural flexibility, we investigated whether intrinsically disordered regions (IDRs) AMP-like properties could exhibit antimicrobial activity. We tested 14 from different IDRs predicted have activity that nearly all them did not display anticipated effects. These failed adopt secondary had compromised membrane interactions, resulting hypothesize evolutionary constraints may prevent folding, even membrane-like environments, limiting their potential. Moreover, our research reveals current predictors fail accurately capture features dealing unstructured sequences. Hence, results presented here far-reaching implications for designing improving strategies therapies infectious diseases.

Язык: Английский

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