Physiological Reviews,
Год журнала:
2024,
Номер
104(4), С. 1643 - 1677
Опубликована: Июль 25, 2024
Representing
severe
morbidity
and
mortality
globally,
respiratory
infections
associated
with
chronic
diseases,
including
complicated
pneumonia,
asthma,
interstitial
lung
disease,
obstructive
pulmonary
are
a
major
public
health
concern.
Lung
the
prevention
of
disease
rely
on
mechanisms
airway
surface
fluid
secretion,
mucociliary
clearance,
adequate
immune
response
to
eradicate
inhaled
pathogens
particulate
matter
from
environment.
The
antimicrobial
proteins
peptides
contribute
maintaining
an
milieu
in
human
lungs
eliminate
prevent
them
causing
diseases.
predominant
molecules
environment
include
α-
β-defensins
cathelicidins,
among
numerous
other
host
defense
antibiofilm
activity
such
as
PLUNC
(palate,
lung,
nasal
epithelium
clone)
family
proteins,
elafin,
collectins,
lactoferrin,
lysozymes,
mucins,
secretory
leukocyte
proteinase
inhibitor,
surfactant
SP-A
SP-D,
RNases.
It
has
been
demonstrated
that
changes
molecule
expression
levels
regulating
inflammation,
potentiating
exacerbations,
pathological
changes,
modifications
severity.
Antimicrobial
also
display
roles
both
anticancer
tumorigenic
effects.
promising
alternative
therapeutics
for
treating
preventing
multidrug-resistant
bacterial
therapies.
Computational and Structural Biotechnology Journal,
Год журнала:
2024,
Номер
23, С. 972 - 981
Опубликована: Фев. 12, 2024
Antimicrobial
peptides
(AMPs)
are
molecules
found
in
most
organisms,
playing
a
vital
role
innate
immune
defense
against
pathogens.
Their
mechanism
of
action
involves
the
disruption
bacterial
cell
membranes,
causing
leakage
cellular
contents
and
ultimately
leading
to
death.
While
AMPs
typically
lack
defined
structure
solution,
they
often
assume
conformation
when
interacting
with
membranes.
Given
this
structural
flexibility,
we
investigated
whether
intrinsically
disordered
regions
(IDRs)
AMP-like
properties
could
exhibit
antimicrobial
activity.
We
tested
14
from
different
IDRs
predicted
have
activity
that
nearly
all
them
did
not
display
anticipated
effects.
These
failed
adopt
secondary
had
compromised
membrane
interactions,
resulting
hypothesize
evolutionary
constraints
may
prevent
folding,
even
membrane-like
environments,
limiting
their
potential.
Moreover,
our
research
reveals
current
predictors
fail
accurately
capture
features
dealing
unstructured
sequences.
Hence,
results
presented
here
far-reaching
implications
for
designing
improving
strategies
therapies
infectious
diseases.
Most
antimicrobial
peptides
(AMPs)
and
anticancer
(ACPs)
fold
into
membrane
disruptive
cationic
amphiphilic
α-helices,
many
of
which
are
however
also
unpredictably
hemolytic
toxic.
Here
we
exploited
the
ability
recurrent
neural
networks
(RNN)
to
distinguish
active
from
inactive
non-hemolytic
AMPs
ACPs
discover
new
ACPs.
Our
discovery
pipeline
involved:
1)
sequence
generation
using
either
a
generative
RNN
or
genetic
algorithm,
2)
classification
for
activity
hemolysis,
3)
selection
novelty,
helicity
amphiphilicity,
4)
synthesis
testing.
Experimental
evaluation
thirty-three
resulted
in
eleven
ACPs,
four
were
non-hemolytic,
with
properties
resembling
those
natural
ACP
lasioglossin
III.
These
experiments
show
first
example
direct
machine
learning
guided
Biofouling,
Год журнала:
2024,
Номер
40(5-6), С. 305 - 332
Опубликована: Июнь 5, 2024
Wound
infections
are
a
significant
concern
in
healthcare,
leading
to
long
healing
times.
Traditional
approaches
for
managing
wound
rely
heavily
on
systemic
antibiotics,
which
associated
with
the
emergence
of
antibiotic-resistant
bacteria.
Therefore,
development
alternative
antibacterial
materials
care
has
gained
considerable
attention.
In
today's
world,
new
generations
dressing
commonly
used
heal
wounds.
These
dressings
keep
and
area
around
it
moist
improve
healing.
However,
this
environment
can
also
foster
an
that
is
favorable
growth
Excessive
antibiotic
use
poses
threat
human
health
causes
bacterial
resistance,
so
new-generation
must
be
designed
developed
reduce
risk
infection.
using
antimicrobial
compounds
minimize
colonization,
making
them
best
way
avoid
open
We
aim
provide
readers
comprehensive
understanding
latest
advancements
management.
Physiological Reviews,
Год журнала:
2024,
Номер
104(4), С. 1643 - 1677
Опубликована: Июль 25, 2024
Representing
severe
morbidity
and
mortality
globally,
respiratory
infections
associated
with
chronic
diseases,
including
complicated
pneumonia,
asthma,
interstitial
lung
disease,
obstructive
pulmonary
are
a
major
public
health
concern.
Lung
the
prevention
of
disease
rely
on
mechanisms
airway
surface
fluid
secretion,
mucociliary
clearance,
adequate
immune
response
to
eradicate
inhaled
pathogens
particulate
matter
from
environment.
The
antimicrobial
proteins
peptides
contribute
maintaining
an
milieu
in
human
lungs
eliminate
prevent
them
causing
diseases.
predominant
molecules
environment
include
α-
β-defensins
cathelicidins,
among
numerous
other
host
defense
antibiofilm
activity
such
as
PLUNC
(palate,
lung,
nasal
epithelium
clone)
family
proteins,
elafin,
collectins,
lactoferrin,
lysozymes,
mucins,
secretory
leukocyte
proteinase
inhibitor,
surfactant
SP-A
SP-D,
RNases.
It
has
been
demonstrated
that
changes
molecule
expression
levels
regulating
inflammation,
potentiating
exacerbations,
pathological
changes,
modifications
severity.
Antimicrobial
also
display
roles
both
anticancer
tumorigenic
effects.
promising
alternative
therapeutics
for
treating
preventing
multidrug-resistant
bacterial
therapies.
